Wiep Klaas Smits

Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social

[Wiep Klaas Smits @SmitsLab]

[🔔] Publication alert! The CloDiCo trial is now published in @NatureComms @NaturePortfolio (Editor's choice!). This is the work of an amazing team, and led by PhD student Annefleur Hensen. Check out this thread [👇] for a summary of the study.
https://t.co/s50Emfm4gv
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[Wiep Klaas Smits @SmitsLab]

The effects of novel oral preclinical PolC inhibitor antibiotic candidates on the gut microbiome in a murine thigh infection model | Microbiology Spectrum https://t.co/tnL3oSsatM

[Wiep Klaas Smits @SmitsLab]

A call for sharing phenotypic antimicrobial susceptibility data alongside bacterial genome sequence data in public archives https://t.co/YsOJP9Tf3D

[Wiep Klaas Smits @SmitsLab]

Genomic and socioeconomic drivers of antimicrobial resistance forecast to 2050: Cell Genomics https://t.co/M96q6Gj8qA

[Wiep Klaas Smits @SmitsLab]

Phases of Clostridioides difficile Infection (CDI) in the United States: The History and Epidemiology of CDI From 1935 to Present https://t.co/DG620MCxxm "... prepare for a different kind of CDI: community-based and insidious rather than hospital-predominant and explosive."

[Wiep Klaas Smits @SmitsLab]

DNA polymerase I and DnaE mediate RNA-templated DNA synthesis over embedded ribonucleotides https://t.co/1OorjmN4Np

[Wiep Klaas Smits @SmitsLab]

The Master Regulator Spo0A Integrates DNA Sequence and Shape to Regulate the Sporulation Kinase Gene kinA in Bacillus subtilis - https://t.co/UW6e8m4SSw

[Wiep Klaas Smits @SmitsLab]

An endolysin-expressing probiotic attenuates Clostridioides difficile infection in germ-free and dysbiotic microbiota-associated mice https://t.co/gSwflh2iVn

[Basler Lab @Basler_Lab]

When Pseudomonas is attacked, it strikes back!
Outer membrane damage triggers a tit-for-tat T6SS retaliation via TagQ/TagR protein complex assembly, activating the PpkA kinase.
Congrats to Maxim & team for uncovering this fascinating mechanism!
https://t.co/ouK2bah0Zj

[Ed Kuijper @EdKuijper2]

The Peggy Lillis Foundation (https://t.co/XfE9ZBQk6N) invites clinicians, researchers, scientists, pharmacists, and industry professionals to submit abstracts for the November 19-20 2026 Clostridioides difficileScientific Symposium. The submission deadline is October 23, 2026.

[Wiep Klaas Smits @SmitsLab]

A competitive BB-ELISA for anti-toxin B neutralising antibodies in assessing risk of recurrent Clostridioides difficile infection: a retrospective cohort study from the MODIFY I and II trials https://t.co/AjUpRSubal

[Wiep Klaas Smits @SmitsLab]

Colonization resistance against Clostridioides difficile is a graded, microbiota-intrinsic property of healthy human gut communities https://t.co/mFFlqgqWmd

[Jörg Stülke @JorgStulke]

Amazing new work from Carol Gross & team in
@PNASNews
! Several new protein functions discovered! #SubtiWiki
The phenotypic landscape of the model firmicute Bacillus subtilis | PNAS https://t.co/SxTkCa7nn2

[Wiep Klaas Smits @SmitsLab]

In @eLife: Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis https://t.co/jZcDoekKRd

[Wiep Klaas Smits @SmitsLab]

Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS https://t.co/zkgjyoXUPV

[Wiep Klaas Smits @SmitsLab]

Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA | PNAS https://t.co/i8Wky6F8VQ

[Wiep Klaas Smits @SmitsLab]

The underappreciated role of rifampin in shaping the epidemiology of RT027-like Clostridioides difficile lineages https://t.co/GiRr5vM3d8

[Wiep Klaas Smits @SmitsLab]

The impact of TcdB conformational dynamics
on vaccination against Clostridioides difficile: https://t.co/RuymufS1E4

[Wiep Klaas Smits @SmitsLab]

Type 2 immunity in Clostridioides difficile infection https://t.co/rzf25ywj1F

[Wiep Klaas Smits @SmitsLab]

The impact of fecal microbiota transplantation on host immunity and epithelial restoration following Clostridioides difficile infection https://t.co/ZejpuQrJ7b

[Akos Nyerges @AkosNyerges]

Proud and excited to share our first preprint 🚀 in which we
• create a high-fitness firewalled organism,
• that stably colonizes the mouse gut for >100 days,
• resists all tested phages in the gut,
• and blocks horizontal gene transfer.
+ Chimera genomes to tailor synthetic