Snædís

deCODE genetics,
Reykjavík University

[Snædís @SnaeGris]

I'm so grateful to my fantastic colleagues at @decodegenetics : @hakon_jon
@Skarkalinn
@PalssonGunnar
@dbeyter
@hannespetur
@ArnaldurGylfas1
@GuillaumOleSan
@MutationalSig
@GudnyAnna
@gnurg
@stefansson_oa
@GisliMasson
@patsule
@bvhalldorsson
@KariStefans @GisliHreinn
7/7

[Snædís @SnaeGris]

Delighted to report that our paper on "Sequence variants affecting the genome-wide rate of germline microsatellite mutations" is now out in @NatureComms, https://t.co/VPWTq86r1A. Thread below: 1/7

[Snædís @SnaeGris]

Further, fathers carrying a variant in NEIL2, a base-excision repair gene, also transmit a larger number of mDNMs to their offspring, while we do not detect an increase in offspring of female carriers. 6/7

[Snædís @SnaeGris]

@Audurkolbra Mæli mikið með teiknimyndinni Coco, góð saga og skemmtileg tónlist.

[Bjarni Halldórsson @bvhalldorsson]

The sequences of 150,119 genomes in the UK biobank

https://t.co/oicZGJ5wne

The first release of our sequencing of all 500k individuals of the UKB.

Below is a short run through of some of our main findings 1/12

[Snædís @SnaeGris]

@CplusKx Ah, had not seen that paper. It seems to have answered your question however, that increased paternal age does indeed increase telomere length in offspring.

[Snædís @SnaeGris]

Excited to share the last paper of my PhD thesis.
We generate microsatellite genotypes for over 50 thousand Icelandic and over 150 thousand UK Biobank samples. https://t.co/axeC046zqO 1/7

[Snædís @SnaeGris]

@CplusKx This is not something we looked into, but since telomere length decreases with age I am not sure how increased paternal age would increase telomere length in the offspring.

[Snædís @SnaeGris]

I thank all my talented collaborators at @decodegenetics : @hakon_jon @Skarkalinn @PalssonGunnar @dbeyter @hannespetur @ArnaldurGylfas1 @GuillaumOleSan @MutationalSig @GudnyAnna @gnurg @stefansson_oa @GisliMasson @patsule @HelgasonAgnar @bvhalldorsson @KariStefans 7/7

[Snædís @SnaeGris]

A SNP in the MSH2 gene increases the number of microsatellite mutations found in offspring of both maternal and paternal carriers. A second SNP, in the NEIL2 gene increases the mutations in only offspring of paternal carriers suggesting a sex specific mutational process.6/7

[Snædís @SnaeGris]

@roslinv Ú, já! Auður er algjör blómaflúr meistari og miðað við það sem ég hef séð á instagram þá er hún perfect fyrir @roslinv . Hún heitir auduryrtattoo á instagram 👌💚

[Snædís @SnaeGris]

@tungufoss @thvengur @hannespetur I stand by my opinion. Þessi spöng ætti að vera on alla daga ársins.