Songhua Hu

Postdoc @HaigisLab @Harvardmed interested in sirtuin biology and metabolite signaling

[Songhua Hu @Song68893177]

Excited to share my PhD work on SIRT4, the last puzzle of mitochondria sirtuin protein.

[Nature Metabolism @NatMetabolism]

Online now! Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle https://t.co/DHZQCh3uvM

[nature @Nature]

Nature research paper: SIRT7 regulates dosage compensation and safeguards the female X chromosome

https://t.co/qWVGrSc9DV

[Cell @CellCellPress]

In the latest issue! Sulfur partitioning from cysteine controls T cell proliferation and effector function https://t.co/odKvXIT2L0

[Aging Science News @AgingBiology]

Plasma proteomic signatures of cellular aging predict human disease
https://t.co/0MX81mzQ0W

[Henning Willers, MD, FASTRO @HenningWillers]

🔥Genomics of aging in @Nature !!🔥

https://t.co/gNhZiRo5GP

[Nature Metabolism @NatMetabolism]

#Throwback

REVIEW | M Abu-Remaileh, @KivancBirsoy et al.

Cellular and organismal function of choline metabolism

https://t.co/lXV4BakGHj

[FrezzaLab @FrezzaLab]

Good Sunday, all. The last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Here is the summary, don't miss these papers https://t.co/YIcWkOGn89 @Bims_BiomedNews #keepreading

"The universe is wider than our views of it."-Henry David Thoreau

[Molecular Cell @MolecularCell]

Aconitase 2 the rescue: A safeguard against excess mitochondrial citrate https://t.co/wcNoZJ1ErA

[Cell Metabolism @Cell_Metabolism]

Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury https://t.co/FIyt2T9F9A

[Nature Metabolism @NatMetabolism]

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase https://t.co/PXQj5Fr9ZD

[E-mit @Emit38935125]

Butyrate extends health and lifespan in mice with mitochondrial deficiency

https://t.co/lxS6sD8ku5

[Nature Metabolism @NatMetabolism]

#Throwback

COMMENT | KS Lee, X Su & T Huan

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics

https://t.co/LTdz9MZpeB

[nature @Nature]

Nature research paper: Postprandial lipid metabolism durably enhances T cell immunity

https://t.co/myej0mZSzk

[Nature Metabolism @NatMetabolism]

COMMENT | NJ Færgeman (U of Southern Denmark)

Long-chain acyl-CoA esters are essential to virtually every aspect of lipid metabolism, yet they are underappreciated and deserve greater attention.

https://t.co/NisxWqhS7H

[Nutrition Science @NutrioSci]

Silencing lipid catabolism determines longevity in response to fasting

[Nature Metabolism @NatMetabolism]

RESEARCH | C Hepler, J Bass et al. (Northwestern University):

Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.

https://t.co/IsGjOOJj1M

[Nature Rev Immunol @NatRevImmunol]

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease https://t.co/REhh3loKaS

[Kivanc Birsoy @KivancBirsoy]

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. https://t.co/cmbOm2u3t7

[Cell Metabolism @Cell_Metabolism]

New! Online now: Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise https://t.co/YiGZ8GRfpN

[Waggoner Lab @LabWaggoner]

Palmitate impairs CD8 T cell mitochondria, suppresses histone acetylation and chromatin accessibility, and blocks effector programs @SciImmunology
https://t.co/bOyG8Fqly2 🇮🇹

[Nature Metabolism @NatMetabolism]

Often forgotten but essential: long-chain acyl-CoAs in metabolic control https://t.co/cCt8Dp6lht