Gad

PhD candidate studying transport mechanisms at Rockefeller University

[Gad @gadmark]

Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. https://t.co/hhsiYw1jXB 🧵 1/9

[shanshan liu @shanshanliu1218]

Excited to share our new work! We identified SLC33A1 as the major ER GSSG exporter that maintains redox balance in the ER lumen.

[Gad @gadmark]

@nicoledelgaudio @shanshanliu1218 @KivancBirsoy @HiteLabMSKCC Thanks Nicole!

[Gad @gadmark]

Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. https://t.co/hhsiYw1jXB 🧵 1/9

[Kivanc Birsoy @KivancBirsoy]

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. https://t.co/cmbOm2u3t7

[Rockefeller University @RockefellerUniv]

In @NatureCellBio: @KivancBirsoy's lab has discovered that the antioxidant glutathione plays a vital role in maintaining smooth operations of a protein-producing hub in the cell called the endoplasmic reticulum by acting as a protein “proofreader.”

🔗: https://t.co/F2cChfBjJT

[Yuyang Liu @YuyangLiu1996]

Check out this amazing work by @shanshanliu1218 and @gadmark !

[Brandon Chen, PhD @BrandonTWChen]

Check out this impressive work and #tweetorial from @gadmark and @shanshanliu1218! If you’re interested in organellar metabolism and metabolite transport, this is a landmark paper on ER redox metabolism and transport👇

[Gad @gadmark]

@AlonMillet @shanshanliu1218 Thank you Alon! Your proteomics and RNA-seq analysis were a key part of this story. Really appreciate everything you brought to this

[Alon Millet @AlonMillet]

Was an honor to contribute to this tremendous study co-led by the brilliant duo of @gadmark and @shanshanliu1218. Check out the thread below to learn more about how SLC33A1 works to maintain ER redox balance!

[Gad @gadmark]

@ToshiNakamura51 @shanshanliu1218 @KivancBirsoy @HiteLabMSKCC Thanks Toshi!

[Gad @gadmark]

Grateful to everyone who made this possible. Thank you to @shanshanliu1218, @KivancBirsoy, @HiteLabMSKCC, and all co-authors. Proud of what we discovered together across @RockefellerUniv and @MSKCancerCenter. 9/9

[Gad @gadmark]

Loss of SLC33A1 shifts PDIs toward oxidized states, triggers ER stress, and creates dependency on ERAD. Disease variants linked to Huppke-Brendel syndrome impair GSSG export. This work connects ER redox biology to neurodegeneration and cancer. 8/9

[Gad @gadmark]

Read my latest newsletter on big pharma’s commercials during tonight’s #SuperBowl . And don’t forget to subscribe https://t.co/Hj0O8SxeeH

[Colin McCarthy @US_Stormwatch]

California state reservoir levels are now at 130% of normal, holding 7 trillion gallons of water.

Remarkable.