Hite Lab

Richard Hite Lab at @MSKCancerCenter

Twitter account run by Hite Lab members

[Lydia Finley @lydfinley]

OK, I’ll bite. We, as scientists, believe our work has value to society. Enough value that we ask for funding from taxpayers and philanthropists. We should be able to justify this value.

[Chia-Hsueh Lee @TheCHLeeLab]

Our work on human urate transporter is out @cell_res. @YaxinDai
single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio

https://t.co/XBdLgxsz8G

[Cell Press @CellPressNews]

Metabolic regulation of the hallmarks of stem cell biology by Jackson (@__btjackson) and Finley (@lydfinley)
https://t.co/4x43KGGvRA

Collection highlight from @CellStemCell

[Kivanc Birsoy @KivancBirsoy]

New work from our lab’s genomics guru @ArtemAKhan with @egamazon. Artem generated a new platform for metabolic gene discovery and identified the mitochondrial choline transporter. @RockefellerUniv @NatureGenet https://t.co/WoeNLFmqJB

[Yeeun Son @Yeeun_Jecy_Son]

Very grateful to give a webinar for BRIC on June 18th Tuesday, 11am KST (or June 17th Monday 10pm EST!) about my recent work on the high-affinity choline and ethanolamine transporter, FLVCR1. https://t.co/9rhsf6GXGv

[Lydia Finley @lydfinley]

Our newest preprint identifies a role for p53 in balancing nutrient supply and demand by enabling phospholipid headgroup recycling 1/

[Yeeun Son @Yeeun_Jecy_Son]

Very grateful that I am invited to give a webinar for ASBMB Lipid Research Division on May 29th, 12-1pm EST. You can register to attend the webinar via the ASBMB website below. Looking forward to meet and discuss research with everyone!
https://t.co/0X1C6qDmWK

[SunLab @JiSunLab]

Our collaboration with @WillPPK on NOX5 is out. We captured NOX5 in different activation states, and used MD simulation to explore the initiation of electron transfer. An unexpected Zn finger was also identified that is critical for function. https://t.co/6sZUaC0wqn

[nature @Nature]

Nature research paper: Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 https://t.co/h6APafDAwQ

[Lydia Finley @lydfinley]

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 @nature
https://t.co/dfQcTMpY8F
Congratulations @HiteLabMSKCC @MSKCancerCenter!!
My favorite part: residues specifying Etn vs Cho uptake. Potential clues for evolution of nutrient uptake programs?

[Yeeun Son @Yeeun_Jecy_Son]

Excited to share our study on a high-affinity choline and ethanolamine transporter, FLVCR1, published today at Nature. I am grateful for my doctoral advisor ,@HiteLabMSKCC , my co-authors and collaborators, @TimCKenny, @ArtemAKhan, and @KivancBirsoy. https://t.co/EgsnhHnQzu

[Hite Lab @HiteLabMSKCC]

Full text link: https://t.co/hz4mWXjNfG
Congratulations to all of the authors and to @RosemaryJCater @pippomancia and colleagues for their identification of the related FLVCR2 as the blood brain barrier choline transporter, published along side our paper @Nature

[Hite Lab @HiteLabMSKCC]

Excited to share our recent study Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 published this week @Nature led by amazing @Yeeun_Jecy_Son in collaboration with @TimCKenny @ArtemAKhan @KivancBirsoy
@MSKCancerCenter
https://t.co/C6VZaR0xBj

[Hite Lab @HiteLabMSKCC]

Structures of choline- and ethanolamine-bound FLVCR1 revealed that the metabolites differentially bind to a common transport site, which enabled identification of mutants that uncouple choline and ethanolamine transport.

[Nature Communications @NatureComms]

Authors from @MSKCancerCenter: @HiteLabMSKCC, @labnavid and @VinaySapuru report structures of IP3 receptor with insights into the biphasic dependence on Ca2+ for channel activity.

https://t.co/dnEKtztTb8

[Hite Lab @HiteLabMSKCC]

Congratulations James! Well deserved.

[Walter Leal @wsleal2014]

BREAKING: Congratulations to now Associate Professor James Letts @LettsScience for his promotion with tenure. @ucdavis is lucky in having you on the faculty.

[Hite Lab @HiteLabMSKCC]

Exciting work from @TimCKenny and @KivancBirsoy identifying FLVCR1 as a mammalian choline transporter! Congratulations to everyone involved in this fun project!

[Kivanc Birsoy @KivancBirsoy]

Our (now published) work identifying the major mammalian choline transporter by fantastic @TimCKenny @RockefellerUniv https://t.co/iRfYcRmdtZ

[Hite Lab @HiteLabMSKCC]

Congratulations @SteveBrohawn and @kerndm on the new story! Really exciting to how much you have been able to learn about the heteromeric channels and their regulation by lipids.

[Steve Brohawn @SteveBrohawn]

Great to see our story led by @kerndm on LRRC8A:C volume regulated anion channels in its final form! Lots of new data since the preprint including structures of a mutant that disrupts lipid block of the pore to activate the channel https://t.co/peK7RDXn7r
https://t.co/Vu918RIpRw

[Alushin_Lab @Alushin_Lab]

After a pandemic hiatus, @BhabhaEkiertLab and I are pleased to organize the next iteration of the NY Area cryo-EM meeting, April 19, 2023 at Rockefeller! See details in the flyer below. Please RT, and apply if you are interested: https://t.co/YXt12wwyzR