SosaLab

Structure & function of biological molecular machines

[SosaLab @SosaLab4]

https://t.co/pVj4DGHxsQ

[SosaLab @SosaLab4]

New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures
https://t.co/nLghpzVsZp

[Luke Rosen @lukebrosen]

Congrats @arnegennerich and all, this is a huge breakthrough to have such detailed structures of KIF1A bound to microtubules! Very important work. Thank you from all our families and the whole community.

[SosaLab @SosaLab4]

High-Resolution structures of microtubule-bound KIF1A and its pathogenic variant P305L https://t.co/fKfMm6Y4cK

[SosaLab @SosaLab4]

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6 https://t.co/D60tfUDkej

[SosaLab @SosaLab4]

Our recent work in collaboration with the Allingham's lab describing the mechanism of combined motile and depolymerization activities by a kinesin-8 just came out! https://t.co/O0DkyPxth9

[SosaLab @SosaLab4]

Our latest preprint on the Kinesin-8 combined motile & microtubule depolymerization mechanism https://t.co/0c4CvxtJRv

[SosaLab @SosaLab4]

https://t.co/PB7YlPOV5b

[SosaLab @SosaLab4]

https://t.co/PB7YlPOV5b
Just out! Significant additions to the preprint https://t.co/f1VEivL9E1 are the separation of coexisting motor-head conformations and improved resolution (2.7-3.9 Å now). @matthieuBenoit1 @HernandoSosa4 @SEMC_NYSBC @cryoEM_Papers #microtubule #kinesin

[SosaLab @SosaLab4]

Glad to see our paper finally coming out with 18 cryo-EM snapshosts of the molecular motor KIF14.
https://t.co/6kRDpN0Xrz

[Matthieu Benoit @matthieuBenoit1]

18 new #cryoEM structures of the kinesin molecular motor KIF14 reveal its translocation mechanism
@SosaLab4
https://t.co/8PqO24fMsc
Collaboration with Kwok lab. Data collected at @SEMC_NYSBC
#EinsteinMed #MTmotors #kinesins #microtubules #biophysics @cryoEM_Papers #cellbiology

[Nature Communications @NatureComms]

Sosa lab @EinsteinMed provides structural insights into kinesin-13 mediated microtubule depolymerisation.

https://t.co/oNVhXvPc8S