Steve Wales

Organic chemist (PhD). Interested in all manner of molecular sciences.

[Steve Wales @SteveMWales]

Our latest work from the @ClaydenGroup in @J_A_C_S explores conformational chirality imparted by unidirectional, cyclic hydrogen bond chains.
https://t.co/bd2fdHqDGY

[Ingo Hartung @HartungIngo]

Holy shit! Revolution Medicines’ #KRas G12D inhibitor RMC-9805 covalently labels the oncogenic aspartate with a aziridine warhead making use of 9 (!) stereocenters to achieve potency, selectivity & stability. My thoughts & prayers are with the process chemistry team. #AACR24

[David R. Liu @davidrliu]

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
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[Shuntaro Amano 天野俊太郎 @ShuntaroAmano]

Autonomous molecular rotary motor by @JonathanClayden , Dr Beatrice Collins & co.. They combined a stereoselective enzymatic oxidation and borane reduction to achieve directional rotation about a C-C bond in a biphenyl system.https://t.co/40m60xmdb4

[Steve Wales @SteveMWales]

@efreynoten Super useful that it gives directly the Boc protected amine

[David R. Liu @davidrliu]

In a major milestone for science, for medicine, and for patients, the world’s first CRISPR drug has been approved in the UK.
“A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) for patients aged 12 and over after a rigorous assessment of its safety, quality and effectiveness.”
Congratulations to the many scientists, doctors, patients, and industry leaders who made this development possible.🍻
https://t.co/pUL956YsG3

[Nature Portfolio @NaturePortfolio]

An article in @NatureBiotech provides a historical perspective on how next-generation sequencing chemistry was developed. 🔒 https://t.co/ZhhKQnAooA

[Chris Parker @_chrisgparker_]

Great to see this exciting story out w/@bmsnews. Novel DGKα/ζ inhibitors discovered via phenotypic HTS promote robust T-cell antitumor immunity. Notably, target ID was enabled using promiscuous PAL probes, where we found hits induce membrane translocation https://t.co/B9gYPjfrS4

[Ania Fryszkowska @fryania]

Ever wondered what it takes to transform an enzymatic reaction on a small scale to a full-fledged industrial process? Our journey with nucleosides—Islatravir and Molnupiravir—has been a wild rollercoaster ride!
https://t.co/N5L6lRGdWG

[Green Ahn @Green_Ahn]

Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? https://t.co/tsTl9rcrxa🧵(1/n)

[Baran Lab @BaranLabReads]

The final version of this study has appeared today in @NatureChemistry : https://t.co/c8UHok5gVz

[The Gamble Lab @gamble_lab]

Exciting opportunity to join our team as a Postdoc working on Bioorthogonal Prodrug Activation Strategies. This is a 2-year post in Ōtepoti Dunedin on the South Island of New Zealand. https://t.co/sQCyJZQHk1

[Steve Wales @SteveMWales]

Presumably also relevant to standard amide couplings and acylations

[Job Boekhoven @BoekhovenLab]

Happy to share our work on the carbodimide-fueled cycle.

This cycle is catalytic; thus, any side product poisons the catalyst. @XiaoyaoChemist studied how this poisoning is prevented.

A must-read when working with carbodiimide-fueled supramolecular chem.
https://t.co/i2GRlsKtxv

[Synthesis Workshop @MatthewHorwitz1]

IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!

Support by sharing!

[Chemistry World @ChemistryWorld]

In 2019, @AstraZeneca launched its Ambition Zero Carbon programme and has seen a 380 kilotons CO2 reduction. Find out how it's developing new chemistry through academic partnerships to deliver a complex portfolio while meeting sustainability goals.
https://t.co/iWbR3XwwIW #ad

[Alessio Ciulli @alessiociulli]

What an inspiring story. So wonderful to listen to such an honest, humble, authentic and so worthy recipient. Love how she highlights the power of perseverance in spite of adversities and offers wise advice of focusing on what you can do. Science celebration, at its best

[Kelsie Snow @kelsieswrites]

Today we hugged Chris for the last time and said goodbye as he went to give four people the gift of life by donating his kidneys, liver and lungs. We are deeply broken and deeply proud. In life and in death, Chris never stopped giving. We walk forward with his light guiding us.

[nagib lab @nagiblab]

Ever wanted a cross-metathesis … but with carbonyls?

Check out Prof @LuminZhang123’s last discovery before starting his own lab at SIOC … in @NatureChemistry

https://t.co/hBFkdsAIYG

It’s like a reverse ozonolysis!

[ACS Central Science @ACSCentSci]

Possible Genetic Risks from Heat-Damaged DNA in Food

NEW #ASAP by @koolchemistry & co-workers at @StanfordUChem @NIST @ColoradoStateU 
Read it here: https://t.co/20GduEalMV

[Steve Wales @SteveMWales]

Mechanistic understanding of the enantiomerisation pathways allows the design of both dynamic and atropisomeric, 'cyclochiral' systems.

[Steve Wales @SteveMWales]

Our latest work from the @ClaydenGroup in @J_A_C_S explores conformational chirality imparted by unidirectional, cyclic hydrogen bond chains.
https://t.co/bd2fdHqDGY