Suchith Mendon

PhD student @ViditaVaidya‘s lab - TIFR Mumbai.

[Drew Schreiner @SchreinerDrew]

Where, exactly, does learning happen in the brain?

Out now @Nature , we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster, but at a cost.🧵 #neuroscience
https://t.co/mS6EJUPVa2
Open link: https://t.co/wiJ16guRj1

[Prachi Garella @garellaprachi]

What is academic humbling and why is it important? 1/10

[Suchith Mendon @SuchitMendon]

@sjo09 @Adam_Rams @circuitfreud @Franklandlab Woah, super exciting! Congratulations to you and the team!

[Xin Jin, PhD @xinjin]

Form follows function, or function dictates form?

📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible @BoliWu!

https://t.co/KlGBbRO4oV

[Suchith Mendon @SuchitMendon]

@drkeithsiau For sure

[Karnataka Health Department @DHFWKA]

India’s First Open-Source Data Repository for Psychiatric Research Launches in Bengaluru.

@CMofKarnataka @DKShivakumar @KarnatakaVarthe

[Neuron @NeuroCellPress]

Online now: A cortical circuit for orchestrating oromanual food manipulation https://t.co/Ed5T3tthV8

[Gisella Vetere @InAnOther]

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
https://t.co/PB0k6AWKQx

[Sergiu P. Pasca @Sergiu_P_Pasca]

This week we are introducing neuromodulatory assembloids

Over the past few years, many circuits and cell-cell interactions have been modeled in assembloids, but these systems have not systematically incorporated neuromodulation.

In this new @biorxivpreprint, we first generated #organoids containing neuromodulatory neuronal populations, including raphe nuclei-like neurons that produce and secrete serotonin, and then integrated them with cortical organoids.

The resulting neuromodulatory #assemboids allowed us to monitor serotonin release using genetically encoded serotonin sensors & its modulation of activity in cortical networks. We also used it to identify defects in assembloids from 22q11.2 deletion syndrome, and found that they can be modulated by SSRIs.

More needs to be done, but this is a first step toward understanding how neuromodulation shapes aspects of human development and disease.

This work was led by a incredible group of scientists in lab: Sabina Kanton, Xiangling Meng, Chunyang Dong, Fikri Birey.

Video below depicts responses to serotonin of neurons in human cortical organoids captured with the PsychLight2 sensor.

[Neuron @NeuroCellPress]

Online now: 20 years of concept cells: From invariant responses to a unique coding of human memory https://t.co/K3lxhiFBo2

[Nature Metabolism @NatMetabolism]

RESEARCH | @AmrapaliAnjali, @JaimedeJuan et al (@InstitutCerveau)

Boosting #mitochondrial metabolism by enhancing Ca2+ retention in the mito matrix improves long-term #memory formation in #flies and #mice

https://t.co/vJMkIWer8k

[Neuron @NeuroCellPress]

Online now: Astrocytic H3 receptors regulate anxiety through GABA signaling https://t.co/lSsO1f0Ufg

[Dingchang Lin @DingchangLin]

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
https://t.co/eVchPCiK6f

[Thomas Biba @ThomasBiba1]

Thrilled to share my first pre-print, where we show that episodic memory formation is theta-rythmic! Thanks to my supervisor, Katherine Duncan, and collaborators for your support and insights. Looking forward to where this research program takes us!
https://t.co/LOtKAHB3mj

[Nature Metabolism @NatMetabolism]

White adipocyte thermogenesis is not an artefact but an in vivo phenomenon https://t.co/CgWkIXNPCn

[Suchith Mendon @SuchitMendon]

A beautiful read!

[Martin Picard @MitoPsychoBio]

The first physical evidence that mitochondria exchange information with one another transformed how I think about these beautiful organelles. From isolated beans to social collective.

In 2015, we discovered that the inner membranes of mitochondria, where the oxygen we breathe and food-derived electrons converge, somehow interact BETWEEN mitochondria.

This is the story, with videos and pictures, of how this happened while working with Meagan McManus @MitoLoveLab in Doug Wallace's lab.

https://t.co/LRE9ocZ2wT

[Neuron @NeuroCellPress]

Online now: All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus https://t.co/jxzw7zPKJ4

[Cell Metabolism @Cell_Metabolism]

New! Online now: Modeling lipid homeostasis using stable isotope tracing and flux analysis https://t.co/F7pO9FYwjc

[Cell Metabolism @Cell_Metabolism]

New! Online now: Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude https://t.co/UAPrUjLpG5