Mahathi Vuruputuri

A budding behavioral and circuit neuroscientist 🧠🐁🍄
Prof. Vidita Vaidya's lab- TIFR Mumbai, India

[Sachin Deshmukh @SacSDesh]

Interested in working in an experimental neuroscience lab? We have a JRF/ Project associate position open In and ANRF sponsorred project: https://t.co/DtCF2oKNNY

[CLaE @leafs_s]

Nature Methods

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics

This paper introduces Neuropixels Opto, a prototype neural probe that combines high-density extracellular electrophysiology with optogenetic stimulation in a single device. The probe has 960 recording sites and two sets of 14 light emitters on a 70-μm-wide, 1-cm-long shank, enabling spatially targeted stimulation with blue and red light while simultaneously recording neural activity.

In mouse cortex, Neuropixels Opto produced high-quality recordings and could selectively activate or silence neurons at different cortical depths. In the striatum and other deep brain regions, it enabled efficient optotagging and helped identify two cell types in parallel.

The main advance is that Neuropixels Opto allows researchers to record, identify, and manipulate neuronal populations with high spatial and temporal precision using one integrated probe. This makes it a powerful tool for studying causal relationships in neural circuits.

https://t.co/44PQYxHqfe

[Michael Gongwer @michaelgongwer]

Thrilled to share our paper out today in @CellCellPress! Transcranial magnetic stimulation can effectively treat depression, but how? We uncovered cell type-specific plasticity driving these antidepressant effects 👇
https://t.co/uKhDFRCUJ3

[Praachi Tiwari @PraachiTiwari]

The final chunk of my PhD is now published online. Grateful for @ViditaVaidya, and co-authors @Mahathi_VR and @Noname_shre
We show that chemogenetically activating, but not inhibiting vHpc->BA projections can module anxiety-like response on the EPM.
https://t.co/GJtLiNtVGy
1/9

[Mahathi Vuruputuri @Mahathi_VR]

@ViditaVaidya Thats cool and useful!

[Vidita Vaidya @ViditaVaidya]

Would be very happy to host a DBT-RA in our research group @TIFR_Bio in case there are interested applicants. Please RT.

[Alex Kwan 關進晞 @kwanalexc]

For those interested in the history of psychedelic research…

I wrote a narrative piece describing studies of psychedelic effects on serotonergic neurons in the dorsal raphe, from late 1960s to 1980s:

https://t.co/BsvBNAlBsD

[Mahathi Vuruputuri @Mahathi_VR]

@SumitSen616 @pnas Congratulations 🎉

[Dr. Amitesh Anand @amitesh1anand]

In this @iScience_CP article, we evolve bacterial ETS variants under distinct metabolic constraints to reveal principles of respiratory flexibility and energy homeostasis.
https://t.co/rjzhMMRllM

[Vidita Vaidya @ViditaVaidya]

Perhaps time to recycle this thread since summer internship requests are high currently.

[Ullas Kolthur @UllasKolthur]

Please repost and join ARUMDA

[BryanRoth @zenbrainest]

Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT

[Vidita Vaidya @ViditaVaidya]

Wonderful talk by Nobel laureate, Prof David MacMillan speaking about organo and photocatalysis @TIFRScience as part of the Nobel Prize Dialogue in partnership with @tatatrusts

[Neuron @NeuroCellPress]

Online now: PV-dependent reorganization of prelimbic cortex sub-engrams during systems consolidation https://t.co/1fLgm5BHyi

[Mahathi Vuruputuri @Mahathi_VR]

Glad and thankful for this opportunity to present our work at the International Brain Initiative IBI2025 conference, being held in Daegu, South Korea! @ViditaVaidya
#IBI #KoreanBrainResearchInstitute #BehavioralNeuroscience

[Alex Kwan 關進晞 @kwanalexc]

New preprint from collaboration with @SN_Lab - 2p imaging of psilocybin's effects on neurovascular coupling 🔬

We found that psilocybin prolongs the neurovascular response, independent of neural activity.

This affects how we should interpret fMRI BOLD studies of #psychedelics‼️

[Vidita Vaidya @ViditaVaidya]

Such a cool tool developed by the Datta Lab @TIFRScience @Ankona6 - facilitated the visualization of early signaling differences between the hallucinogenic (DOI) vs non-halluconogenic 5-HT2A ligands

[Mahathi Vuruputuri @Mahathi_VR]

@MayoOnTheBrain Thank you Leah- It was a pleasure meeting you too!

[Mahathi Vuruputuri @Mahathi_VR]

It was an immense pleasure to have gotten an opportunity to give an oral and a poster presentation of our work at the #GRCPsychedelics ! Also grateful for the travel award I received from the Heffter's foundation..!

[Bita Moghaddam بيتا مقدم @bita137]

New lab paper by Merridee Lefner identifying a novel role for VTA GABA neurons in behavioral flexibility

GABA, but NOT dopamine, neuron activation correlates with behavior when cues unexpectedly shift from predicting punishment to predicting reward

https://t.co/qig7j7ikUi