SumTheLit

Dr. Read 🧪🧫🔬🥼

Summarizing the Literature📚
Follow me on my journey as I read the primary literature. 🥽🔭📖🐙
Science and math are cool ✌️

[Rachel Stubler @RachelStubler]

Happy #MicroscopyMonday, #MucusMonday, and MLK Day!
Alcian blue staining of the colon highlighting mucus filled goblet cells and the protective inner mucus layer in blue.
#MucusMatters #MoreMucus #microscopy #sciart #pathart #histoart #bioart #colon #intestine

[SumTheLit @SumTheLit]

Each little dot in this image is a cell with a blue nucleus and a green fluorescent stain. 🧫

This image is a tiled image meaning it is many small images stitched together into one large image. 🪡🧵 Can you see the 'tiling' pattern?

#sciart #microscopymonday #biology #science

[SumTheLit @SumTheLit]

Two decades ago, these authors developed monomeric fluorescent proteins with delicious sounding names.
🍒🍌🍈🍓🍊

One of the cell lines I use in my research is tagged with mCherry - now I know where it comes from! 🙌🪼

Primary source DOI: 10.1038/nbt1037

#sumthelit #biotech

[SumTheLit @SumTheLit]

How would you use fluorescent proteins? 🪼🌈💡

See a new reel on my instagram: @sumthelit

https://t.co/fby1HDqyAS

[SumTheLit @SumTheLit]

Welcome to 2024, we can see the brain like never before yet we still don't know how consciousness works. 🧠✌️

Keep it curious, we have a lot more questions to answer. 🥼🥳

#scientist #scienceiscool

[Science Magazine @ScienceMagazine]

Researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. https://t.co/mm6b4swBvn

[SumTheLit @SumTheLit]

This week, I had some fun messing with more color arrangements for ‘burst cell’ (aka ‘failed experiment’) images. 🥲🔬🧫

I then passed my images along to someone who actually studies art! 🎨💻Swipe to see his edits.

#sciart #fluorescencemicroscopy #sumthelit

[SumTheLit @SumTheLit]

Let's summarize a med chem article (DOI: 10.1126/science.abl861). ✨🧠

The authors of this paper used the crystal structures of psychedelics and similar compounds to design a “nonhallucinogenic psychedelic”.🧪🩺🍄🌿🥼

#psychedelics #medchem #sumthelit #LSD #psilocin #psilocybin

[SumTheLit @SumTheLit]

How can researchers use the crystal structures of psilocin and serotonin (bound to ther biological target 5HT2A) to design a nonhallucinogenic psychedelic? 🩺🧪🍄🌿🥼

DOI: 10.1126/science.abl861

#psychedelics #medchem #sumthelit #LSD #psilocin #psilocybin #nonhallucinogenic

[SumTheLit @SumTheLit]

What do these images make you think of? 🌌🌃🔭🌉

They're actually microscopic images at 20x magnification from one of my cell experiments this week. 🧪🧫🔬💻

Which staining looks better to you?

#microscopy #fluorescentmicroscopy #microscopymonday

[SumTheLit @SumTheLit]

New video on instagram 🧠🍄✨🥳

Click to learn more about nonhallucinogenic psychedelics research 💠🤔🧪

Video by @sumthelit

https://t.co/TsITo6f6pX

[SumTheLit @SumTheLit]

Beating heart cells (cardiomyocytes) in a Petri dish!

❤️🫀🧫🔬🥼✨

[Massimo @Rainmaker1973]

These are heart cells. Beating.

Using stem cells, scientists can grow cardiac tissue in a petri dish. The cells self-organize to form microchambers, which begin to beat like a full-sized heart

[📹 Jessica Gluck]

[SumTheLit @SumTheLit]

Here, I stained the same protein in the same cell line but with different fluorophores (either direct 🔴 or indirect 🟢🟡 conjugation). The nuclei are in blue 🔵.

What can I learn from an experiment like this? 🤔

#fluorescencemicroscopy #microscopy #microscopymonday #mydata

[SumTheLit @SumTheLit]

Regulating neurotransmitters like dopamine, norepinephrine, and serotonin in circulation can have a significant impact on neurological disorders like depression, anxiety, ADHD, schizophrenia, Parkinson’s disease, and more.
🧠🧪🩻🩺

[SumTheLit @SumTheLit]

I think pink might be my new favorite nuclei marker color... 🩷🧫🦩🎟️

#microscopymonday

[Rachel Stubler @RachelStubler]

Happy #MicroscopyMonday! Immunofluorescence staining of the colon highlighting the brush border (green), cell membrane (white), tuft cells (yellow), and nuclei (pink).

#microscopy #sciart #pathart #bioart #histoart #intestine

[SumTheLit @SumTheLit]

So cool!🐟🔬

Axial elongation is the lengthening of the axon (long part) of a neuron. 🧠🧐

#microscopymonday

[Merlin Lange @Merlin_Lange]

Capturing the axial elongation of a zebrafish embryo (back and forth) using our single objective LSM DaXi #FluorescenceFriday #zebrahub #zebrafish 🐟🔬

[SumTheLit @SumTheLit]

Beyond cool! 🙌🧬🤯

#DNA @ScienceMagazine

[Science Magazine @ScienceMagazine]

In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds.

Learn more on #DNADay ⬇️
📄: https://t.co/GlRfbfSUt6
📄: https://t.co/R22Dk0HVyo

[SumTheLit @SumTheLit]

Fighting cancer with chemotherapeutics, how do they work? 💪💊🩺

#sumthelit #cancer #tumor #drugtreatment #science #medicine #biology #chemo #chemotherapy

[SumTheLit @SumTheLit]

How might a tumor acquire drug resistance? Why is treating cancer so tricky?🫀🫁🧠🩻🩺

#sumthelit #cancer #tumor #drugtreatment #science #medicine #biology

[SumTheLit @SumTheLit]

Conseil européen pour la Recherche nucléaire (CERN)

CERN, demonstrating how collaborative science is a win since 1954. 🫱🏼‍🫲🏾⚛

#CERN #HiggsBoson #Science #sumthelit

[CERN @CERN]

CMS releases #HiggsBoson discovery data to the public

The @CMSExperiment has recently released, in electronic format, the combination of the measurements that contributed to establishing the discovery of the Higgs boson in 2012.

This release coincides with the publication of the Combine software – the statistical analysis tool that CMS developed during the first run of #LHC, to search for the unique particle, which has since been adopted throughout the collaboration.

Find out more: https://t.co/tsHbrEpHam

[SumTheLit @SumTheLit]

Why might two patients, both diagnosed with triple negative breast cancer (TNBC), respond differently to the same treatment? 🩻🩺🫀🫁🧠

Tumor heterogeneity is an explanation.

#sumthelit #cancer #tumor #drugtreatment #science #medicine #biology