Suresh Shanmugham

[Mountain View Spartan Athletics @MtnViewAth]

What a game!

[Matt Walker @sleepdiplomat]

@etoosh Alcohol is a sedative, not a sleep aid. 🍷 It fragments your sleep, increasing awakenings, and is a potent suppressor of REM sleep, diminishing both the quantity and electrical quality of this critical brain state.
#Alcohol #Sleep

https://t.co/diEGFCxWYT

[humanOS.me @humanOS_me]

At the same time, immune cells became hyperreactive.

When stimulated, they showed more than double the activation seen at baseline — and this heightened reactivity persisted after recovery.

The immune system wasn’t just weaker — it was out of balance.

[humanOS.me @humanOS_me]

💡 Key takeaway: Walking uphill, even at a slow pace, recruits more muscle fibers, raises brain lactate, and increases BDNF, making it a powerful tool for brain health.

Study: https://t.co/pl7bhyqz4u

[humanOS.me @humanOS_me]

Different types of exercise activate different autophagic pathways:

🚴🏼 Aerobic exercise (running, cycling) engages AMPK & mTOR, enhancing mitochondrial quality.

🏋🏼‍♂️ Anaerobic exercise (resistance training) activates PI3K/Akt, driving muscle repair and growth.

[humanOS.me @humanOS_me]

🚨 Shift work & sleep debt increase risk of infection.

A study of 1,335 nurses found:

Night work → 49% higher odds of common cold

Sleep debt greater than 2 hours → 3.9x higher odds of pneumonia/bronchitis

Clear dose-response: More sleep debt = higher risk

[humanOS.me @humanOS_me]

Different types of monocytes have distinct jobs in the immune system.

Classical monocytes are disciplined first responders, prepared to intervene in response to pathogens, but reined in.

Nonclassical monocytes are hypervigilant patrollers; most prone to inflammatory responses.

[humanOS.me @humanOS_me]

Your immune system never sleeps.

While you rest, immune cells are busy rebalancing, learning from past threats, and fine-tuning their defenses.

But what happens when sleep is disrupted?

A new study found an intriguing connection between sleep and immune balance.

🧵

[Matt Walker @sleepdiplomat]

Suvorexant: Fat-Burning Sleep Aid? 🤔 New research shows it boosts metabolism during sleep, burning fat while preserving muscle! 💪 Could this be the breakthrough we've been waiting for? #sleep #metabolism

[Matt Walker @sleepdiplomat]

🤯 Imagine losing weight effortlessly while you sleep! A recent study revealed Suvorexant boosted participants' fat oxidation during sleep by a staggering 35%. What do YOU think of these findings? #futuristic #wellness

[Matt Walker @sleepdiplomat]

Feeling rested vs. sleeping well: Is there a difference? 😴 This study on couples explores the paradox of sleep satisfaction. #SleepScience #Couples #RelationshipGoals

[Riley Goodside @goodside]

Human preference LLM arenas are poorly suited for evaluating ASCII art because the ASCII art that most impresses a human is often verbatim regurgitation of an existing human work and this is rarely true for text.

Votes on ASCII art should be detected and thrown out IMO.

[Los Altos Police @LosAltosPD]

Interested in joining our team? Visit https://t.co/YJ8kvdr0b2 for more information and to apply! #WeAreHiring #LosAltosPolice #Police

[Suresh Shanmugham @Suresh_SaamaCap]

Dasera demonstrating its thought leadership on #insiderthreats

[Dasera @DaseraInc]

15 CISOs, CIOs, and tech leaders tell us their strategy for dealing with insider threats. Read the Red Book of Insider Threats - Summer 2020
https://t.co/Tr9mAquIxI

#RedBook #Cybersecurity

[Atul Gawande @Atul_Gawande]

Hospitals reported 5,142 cases May 14-Jun 21 where patients developed COVID-19 after >2 weeks in the hospital. This is clearly an underestimate. Vital for @CDCgov to track down what the factors are. The anecdotes cite lack of universal masks. https://t.co/jC0yYpL2bP

[David Cancel @dcancel]

1/ What I wish I knew when I was younger 👇🏽

[CNN Breaking News @cnnbrk]

A medicine that may treat and prevent Covid-19 is now being tested in patients in multiple sites around the US, Regeneron Pharmaceuticals Inc. announced. If successful, Regeneron hopes it could be available by the fall. https://t.co/XKh0m7HwsO

[Suresh Shanmugham @Suresh_SaamaCap]

Another exceptional memo from @HowardMarksBook on #Uncertainty

[Oaktree @Oaktree]

True expertise is scarce and limited in scope. @HowardMarksBook’s postscript to his recent memo explains why we should be careful about the "experts" we listen to and the weight we assign to their pronouncements: Read/subscribe: https://t.co/iUSTt6ZmQM #OaktreeInsights

[Suresh Shanmugham @Suresh_SaamaCap]

@shachinb Wow. Brings back my memories of our trip to Santorini in 2005.

[Suresh Shanmugham @Suresh_SaamaCap]

@ganeshk03 @tvmahalingam @sparkliveapp @soumpaul @srinirai Such shocking news. Left this earth far too early. Life can change in an instant for any of us. Condolences to his family and friends.