Sylvan Baca MD PhD (Hiring!)

GU oncologist and computational epigenomics enthusiast at @DanaFarber, Assistant Professor @harvardmed

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

We're #hiring a computational #postdoc! PhD in computer science or other quantitative field? Join our mission: push the boundaries of precision #oncology with computational #epigenomics and #AI.
https://t.co/OtKN34QnJT Please RT!

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Great collaborating with Ning Shen, @zezhangzzz, and @keegankorthauer on this new paper in @CommsBio! It provides a robust new framework for deconvolving cell type-associated DNA methylation signatures from (cell-free)MeDIP-seq data: https://t.co/Pnn3X2FW5a

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Hard to believe that @RazaneHChehade is moving on after a productive postdoc fellowship in the lab. Best of luck on your next steps - @PittPediatrics is very fortunate to have you, and I can't wait to see what you accomplish next!

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Proud to see one of my first mentors, Dr. Mary-Ellen Taplin, expanding options for patients with high-risk localized prostate cancer. Congrats to the PROTEUS team on this practice-changing trial! @ASCO @DanaFarber @DanaFarber_GU

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

A pleasure working with David Lee and @KimmieNgMD on this perspective: https://t.co/nXtXRp254z.

Neat approach in the corresponding paper: Using DNA methylation signatures of environmental exposures to investigate what's driving the alarming rise in early-onset colorectal cancer.

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Congratulations @zezhangzzz on your scholar-in-training award at @AACR! I'm thrilled to watch you and the team take cancer diagnostics in new directions and improve patient care.

[Ze Zhang @zezhangzzz]

Great honor to have our work recognized by the prestigious @AACR. Kudos to the team @SylvanBacaLab! https://t.co/v7xdB5pLG7

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Our latest collaboration with #MattFreedman and @Oser_Lab on resistance to tarlatamab: https://t.co/3Ei2gYY3Gm. An exciting framework for studying cancer resistance: observations from patients using epigenomic #LiquidBiopsy -> functional validation in mouse models.

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Looking forward to this summit @broadinstitute - great speaker lineup!

[Faden Lab @FadenLab]

Thrilled to host the inaugural Head and Neck Cancer Liquid Biopsy Summit July 17th, 2026, @broadinstitute in Cambridge MA

See the outstanding speaker lineup on the meeting website: https://t.co/JFR0a1Exeq

Registration is free and open to all

Additional details 👇👇👇

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Great opportunity in a fantastic lab!

[Ryan Collins @RyanLCollins13]

📣 We’re hiring a computational genomics postdoc! 📣

Our lab at @DanaFarber is looking for a postdoctoral fellow — details👇

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Great review on determinants and consequences of nucleosome spacing - very cool what you can learn from such a "simple" feature! @TeifLab

[Teif Lab @TeifLab]

Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: https://t.co/Z1TgEYxBH8

A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy!
#nucleosomics #nucleosome #chromatin #cfDNA

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Thanks for highlighting this great work by @RashadNawfal and team on blood-based readouts of DLL3 expression in cancer, @DrChoueiri!

[Toni Choueiri, MD @DrChoueiri]

Amazing work out of @SylvanBacaLab by our very own raising star @RashadNawfal

Plasma cfChIP-seq (H3K4me3) predicted DLL3 expression in NEPC.

Higher promoter signal in NEPC tumors distinguishing DLL3+ vs DLL3–

Potential blood-based approach to guide DLL3-targeted therapy selection.

#GU26 #ProstateCancer #NEPC
@OncoAlert

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Thrilled to share the latest from @gungulati and team in collab with #MattFreedman. #LiquidBiopsy can reveal gene expression in cancer by integrating circulating histone mods and cfDNA fragmentation patterns. Excited to see how this expands the reach of precision oncology!

[Gunsagar Gulati @gungulati]

We infer earthquakes from distant vibrations and stars from photons emitted light-years away.

Can we reconstruct a patient’s tumor biology from the signals it sheds into blood?

Introducing APEX (Associating Plasma Epigenomics with eXpression), our framework for inferring cancer expression from plasma.

Preprint: https://t.co/G2njHRl29y

@biorxivpreprint @DanaFarber @DrChoueiri @SylvanBacaLab #FreedmanLab

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Thrilled to share this collaboration with #MattFreedman and @DrChoueiri led by @sarahaboulaiwi @adib_elio, and @WinstonCheung5. Cancer epigenomes from patients have a lot to teach us about how cancer develops, from germline risk to metastasis. #TranslationalEpigenomics

[Sarah Abou Alaiwi @sarahaboualaiwi]

Very excited our paper is online! @adib_elio @WinstonCheung5 @SylvanBacaLab @DrChoueiri #MattFreedman. https://t.co/Qte5qBrE61 We profile chromatin and transcription across normal kidney →primary ccRCC→metastasis to define what changes (and what persists) during progression 1/

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Great collaboration with @sriviswanathan on epigenomic liquid biopsy in translocation RCC, led by @SimonGarinet and @KarlSemaan. A nice framework for diagnosing and monitoring translocation-driven cancers that have few genomic alterations.

[Srinivas Viswanathan @srviswanathan]

Our latest paper is now out in @jclinicalinvest!

🎉Huge congrats to superstars🌟 @simongarinet & @karlsemaan on this study with @sylvanbacalab #FreedmanLab @drchoueiri. [1]

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Excited to share some of our lab's work on epigenomic liquid biopsy for precision oncology tomorrow at the DFCI Seminars in Oncology series tomorrow!

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

It's a privilege to work with such a compassionate and talented group of genitourinary oncologists (plus one GI oncologist, if you can spot him @gungulati !)

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Great tweetorial on the next chapter in precision oncology by @gungulati

[Gunsagar Gulati @gungulati]

Are liquid biopsy tools that capture gene expression the future of precision oncology? We tackle this question and share our vision for Precision Oncology 2.0 in

@JCO_ASCO: https://t.co/JJAMFKIzDT with
@DrChoueiri , #MattFreedman, @SylvanBacaLab
at @DanaFarber
.

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Thrilled to share @gungulati's perspective piece in @JCO_ASCO describing how expression-based liquid biopsy will help guide a new wave of cancer treatments.

[Toni Choueiri, MD @DrChoueiri]

JUST IN: Congrats to our own @gungulati @SylvanBacaLab #Mattfreedman @DanaFarber + @DanaFarber_GU

New commentary published in @JCO_ASCO @ASCO :

From mutations to expression=> Precision Oncology 2.0 reveals that expression-based liquid biopsy can guide therapy selection, switching and resistance monitoring

Exciting for 2026 and beyond!

https://t.co/HFcp01xyQm

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

@DrChoueiri has been a mentor in many ways, but this week, primarily in hairstyle.

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

Excited to share the lab's latest from @zezhangzzz and team: https://t.co/lnCE3eWbto. SNAP is a #nextflow-based pipeline for emerging #LiquidBiopsy datatypes including cfChIP-seq. It fills a need for analysis methods tailored to immunoprecipitation-based cfDNA profiling.

[Sylvan Baca MD PhD (Hiring!) @SylvanBacaLab]

@CterminiPhD Great suggestions on this thread. Two more: 1. Find a mentor who is heavily invested in your success and will advocate for you; 2. There are many venues to have an impactful career in medicine/science beyond academia.