Michael Samuel

Cancer Researcher; researching Tumor-Microenvironment interactions @CCB_Research.

[Sharad Kumar @molregulation]

Great to see this work led by Bekky Feltham @WEHI_research and the global ubiquitin community now published. Happy to have contributed to the curation of HECT E3s.@CCB_Research
The E3-ome gene-centric compendium reveals the human E3 ligase landsca... https://t.co/MqMJS9D7NR

[Michael Samuel @TMEM_Samuel]

@deniswirtz @DrSarahBoyle Thank you 🙏🏽

[Michael Samuel @TMEM_Samuel]

I am delighted to be able to share that our latest paper arising from a project co-led by @DrSarahBoyle and me is now out in the world, published in AAAS Science Advances: https://t.co/Qihz05OGWD.

[Michael Samuel @TMEM_Samuel]

Thank you to all our lab members and colleagues who contributed to this research, and the funding bodies who supported our work: @hosp_research, @nhmrc @arc_gov_au , @WorldwideCancer

[Michael Samuel @TMEM_Samuel]

Sarah has a more detailed narrative of our findings here: https://t.co/qCzSfa6tTN

[Sarah Boyle 👩🏻‍🔬🎀 @DrSarahBoyle]

We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. https://t.co/TzwsRBuMHx

[Sarah Boyle 👩🏻‍🔬🎀 @DrSarahBoyle]

https://t.co/9vYCNpOQ9f

[Sarah Boyle 👩🏻‍🔬🎀 @DrSarahBoyle]

Why ‘being squeezed’ helps breast cancer cells to thrive

“intense physical pressure at early stages of the disease… leaves a lasting ‘mechanical memory’ in breast cancer cells, promoting aggressive behaviour after the pressure itself has been relieved.”

https://t.co/JvTmdEgVml

[Sarah Boyle 👩🏻‍🔬🎀 @DrSarahBoyle]

We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. https://t.co/TzwsRBuMHx

[Sarah Boyle 👩🏻‍🔬🎀 @DrSarahBoyle]

In a study co-led by myself and Prof @TMEM_Samuel at @CCB_Research, Adelaide University, we found breast cancer cells subjected to compression, such as experienced during tumour growth in the restricted mammary duct, are changed in ways that worsen the resulting tumours.

[Mechanobiology Institute @MBIsg]

More on compression! @TMEM_Samuel @CCB_Research detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025

[Michael Samuel @TMEM_Samuel]

Our lab is seeking a postdoctoral scientist to work with us on an exciting new project modelling cancer extracellular matrix structures using nanofabrication approaches. Full details are at https://t.co/VRL5D94hWv.

[UniSA (this account is no longer active) @UniversitySA]

https://t.co/hDeIe0azZA
Five UniSA projects awarded $5mill in @NHMRC grants announced today are set to improve cancer treatment, & help people prioritise their time building health

[Claudine Bonder @claudine_bonder]

Summer is coming and so are the @CCB_Research @UniversitySA 2024/25 Vacation Scholarships for a 4-8 week research intensive in cancer biology!!
There are also $100/week top ups kindly donated by the Fuss Family and @lashesofchange
closes: 22 Sept 👇👇👇
https://t.co/1kmKNg6h5B

[Sophie Wiszniak @SophieWiszniak]

Our colleague @s_pitson at @CCB_Research @UniversitySA will be trekking the Kakoda Trail in October raising funds for @NeuroSurgRF, particularly for an important research project led by A/Prof. Quenten Schwarz to find better treatments for children with brain cancers.

[Michael Samuel @TMEM_Samuel]

@SamStehbens @robertr33 @arc_gov_au @drDJVDavid @NatureCellBio Congratulations, @SamStehbens! Great to see this beautiful story out in the world :)

[ANZSCDB @ANZSCDB]

We are excited to announce the 12th ANZSCDB South Australia meeting taking place on October 16, 2024! Join us for insightful talks from @McGlinnLab, @CedricBardyLab, and @Lisa_M_Nic at @unisa. Don't miss this packed event!

#devbio #science #cellbiology

[Cytoskeleton Journal @CytoskelJournal]

Another exciting #openaccess paper in #cytoskeleton @CytoskelJournal Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell #carcinoma https://t.co/DzAnVvLke7 @TMEM_Samuel #cancer #science #cell #cellbiology