Theo Hirsch

Cancer Genomics Researcher @Inserm, @CRCordeliers | Liver cancer evolution in children and adults | Bulk, single-cell, spatial | Mosaicism

[Theo Hirsch @TZ_Hirsch]

So proud of @LongPan61162464, PhD work now out in @NatureComms
Please read his thread below 👇
To me, this is the most comprehensive molecular classification of HCC available today.
Want to explore multiomics data of 529 HCCs? Try our interactive app:
🔗 https://t.co/nYRyBHzWD9

[Long Pan | 潘龙 @LongPan61162464]

Delighted to share my PhD work is now published in Nat Commun! 💯
We established a large HCC dataset including 529 tumors from 461 patients treated in Western countries, integrating WGS/WES, RNA-seq, DNA methylation and proteomics data.
https://t.co/PikMHtqIQC

[Long Pan | 潘龙 @LongPan61162464]

To facilitate data exploration, we developed an interactive web-based tool: https://t.co/suyOEQONyG (built in one month — probably much faster nowadays with AI 😀).

[Long Pan | 潘龙 @LongPan61162464]

Delighted to share my PhD work is now published in Nat Commun! 💯
We established a large HCC dataset including 529 tumors from 461 patients treated in Western countries, integrating WGS/WES, RNA-seq, DNA methylation and proteomics data.
https://t.co/PikMHtqIQC

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Nate Krah @N8Krah]

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

[Pascal Chappert @PChappert]

🚨 Proud to share our new study in @CellPressNews: B cells producing auto-Abs that neutralize type I IFNs in severe viral infections. Work from AI2B_lab @NeckerInem, @casanova_lab, @GorochovG and Rey’s labs @institutpasteur. https://t.co/hrx6OdZqQH

[Amy Fan @amycfanphd]

Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.

https://t.co/9XENtFrB4h

#immunology #cellbiology @immunox @ucsf

[Sonya Hessey @SonyaHessey]

Thrilled that our manuscript ‘Evolutionary characterization of Lung Cancer metastasis’ in #TRACERx & #PEACE was published in @Nature today. Here is a summary:

[Ben Adler @ben_a_adler]

Saying it because @kenjmloi didn't:
This is really close to a RNA system that targets protein sequences because of wobble bases in codons.

Truly amazing discovery!

[Kenneth Loi @kenjmloi]

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.

We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.

Thread + link below.

[Inigo Martincorena @imartincorena]

Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] https://t.co/8kQZ0NWl7X

[Theo Hirsch @TZ_Hirsch]

Our global, multi-institutional re-analysis confirms the absence of the DNAJB1::PRKACA fusion in hepatoblastoma https://t.co/GaRbtH5lFx via @Cancers_MDPI

[Garyk Brixi @garykbrixi]

Evo 2 is out in Nature today, showing that genome language models can predict and design across the full complexity of life, from phages to eukaryotes.

A few surprises from the project, including how ignoring trillions of nucleotides was key to getting a good model. 🧵

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

INTERESTED IN SINGLE-CELL LINEAGE TRACING?

New review @NatureRevGenet from the @FraticelliLab. 🎉🎉

https://t.co/v3oa8gUUNj

With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY!

Read link: https://t.co/amrOWuQvVs

[Jamie Blundell @jrblundell]

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster.

We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: https://t.co/DMyHA5TIS0 🧵

[Josephine Yates @JoYatesResearch]

🧵 New paper from the Boeva @val_boeva lab!

How can we reliably identify cancer cell states from single-cell RNA-seq?🤔

Florian Barkmann and I, with our co-authors, tackle this in our new CanSig benchmark, published in Cancer Research
https://t.co/K3Db9EJdbn

[Uri Alon @UriAlonWeizmann]

Biopsies provide just a single snapshot of the underlying tissue. In our recent work published in @Nature, we made progress in estimating tissue-level dynamics from a biopsy using spatial proteomics.

https://t.co/fLQgUqvNNC

[Sandra Rebouissou @SRebouissou]

Happy to share our recent work. Targeting ATR to overcome cisplatin resistance in hepatoblastoma - Journal of Hepatology https://t.co/oluAcURolQ

[Theo Hirsch @TZ_Hirsch]

@campani_claudia @EASLnews Congratulations @campani_claudia 👏👏

[Claudia Campani @campani_claudia]

Grateful to EASL for supporting this research fellowship and investing in early-career scientists! @EASLnews