Karsten Eastman

Cofounder and Chief Executive Officer of Sethera Therapeutics

[Karsten Eastman @Taikade]

Wild to wake up to this-- some of the science we have been working on was highlighted by @nypost. Great to see!
https://t.co/Vx2XpGlqra

[Progress, Potential, And Possibilities @ProgressPotent1]

What if we could make next-gen peptide drugs (think supercharged Ozempic) more stable, longer-lasting, and able to hit "undruggable" diseases? 💊💉⚗️

A radical enzyme called PapB just unlocked that - one enzymatic step to staple peptides into durable rings.

Interview w/ discoverer Dr. Karsten Eastman @Taikade - CEO @SetheraTx drops today! 🔥

Watch: https://t.co/GRxDwAUAI3

#PeptideTherapeutics #Biotech #GLP1 #DrugDiscovery @JVPR_NY

[Progress, Potential, And Possibilities @ProgressPotent1]

What if we could make next-gen peptide drugs (think supercharged Ozempic) more stable, longer-lasting, and able to hit "undruggable" diseases? 💊💉⚗️

A radical enzyme called PapB just unlocked that - one enzymatic step to staple peptides into durable rings.

Interview w/ discoverer Dr. Karsten Eastman @Taikade - CEO @SetheraTx drops today! 🔥

#PeptideTherapeutics #Biotech #GLP1 #DrugDiscovery @JVPR_NY

[Karsten Eastman @Taikade]

Enzymes as design tools, not just catalysts. This interview covers how we harness rSAM chemistry to create recombinant polymacrocyclic peptides with drug-like properties. https://t.co/dXay4TkGyi #Peptides #DrugDiscovery #Enzymology

[Sethera Therapeutics @SetheraTx]

Enzyme PapB could boost diabetes and obesity peptide drugs https://t.co/vToDDhutYj

[Karsten Eastman @Taikade]

Check out our recent publication on enzymatic modification of GLP1 analogs! We think this is really exciting because it opens many unique doors for architectural changes in late-stage peptide development. https://t.co/mCHIaYyZXp

[Sethera Therapeutics @SetheraTx]

Sethera's first paper has released at PNAS. Check it out here! https://t.co/QCXvqvWavJ #peptides #enzymes #science

[Karsten Eastman @Taikade]

@Vahooster and I were interviewed about the unusual enzyme that we have been working with. Check it out here: https://t.co/Yop8V2Fneu

[Karsten Eastman @Taikade]

Natural enzyme expands possibilities for peptide drug discovery https://t.co/fL0vBTGmyL via @physorg_com

[Karsten Eastman @Taikade]

@MinteerLab Thank you!

[a. g. roberts chemistry @agr_chemistry]

A promiscuous #rSAM enzyme enables diverse peptide cross-linking https://t.co/YIpsGKNgKd Working together with @taikade @MCMChem Paul Oblad, and @Vahooster (Bandarian) we show that PapB has a high tolerance for variations in the peptide substrate. @UtahChemistry @UUtah

[Journal of Biological Chemistry @jbiolchem]

New in JBC press: "Scientists' findings lead to a new paradigm involving intermolecular electron transfer steps in the activation of rSAM enzymes that require multiple iron-sulfur clusters for turnover."
Learn more:
https://t.co/fRPufzwjFg

[Karsten Eastman @Taikade]

@ACSBioMed @Vahooster @UtahChemistry Very glad to see this out!

[ACS Publications Bio & Med Chem Content @ACSBioMed]

A Promiscuous #rSAM Enzyme Enables Diverse Peptide Crosslinking

By Vahe Bandarian @Vahooster @UtahChemistry 

🔓 Open access in ACS Bio & Med Chem Au 👉 https://t.co/vmI0axbMGt

#ACSBioMedChemAu

[Lucio Saverio Eastman @LucioEastman]

Another publication from my son, Karsten @Taikade, and others at @jbiolchem. Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation. https://t.co/Oj6AHqntEA

[Karsten Eastman @Taikade]

Paper #3 is out! We were able to build and generate evidence for a new model for reductive activation in rSAM enzymes. We really hope other labs try the FMN + NADPH experiments!
https://t.co/mL4FTVRdZN

[Vahe Bandarian @Vahooster]

Starting to understand how a radical SAM enzyme makes a thioether crosslink - the auxiliary iron-sulfur cluster binds the substrate!
https://t.co/vNt3iuRO3w

[J. Am. Chem. Soc. @J_A_C_S]

Peptide Selenocysteine Substitutions Reveal Direct Substrate–Enzyme Interactions at Auxiliary Clusters in Radical S-Adenosyl-l-methionine Maturases @OHSUNews @UtahChemistry @Vahooster @UUtah #Peptide #Selenocysteine #Clusters #Radical #SAM #Maturases https://t.co/TDIwTzN08w

[Karsten Eastman @Taikade]

@J_A_C_S @OHSUNews @UtahChemistry @Vahooster @UUtah I am so glad this work is finally out!

[Lucio Saverio Eastman @LucioEastman]

My eldest son, Karsten (@Taikade), has been published again in the Journal of the American Chemical Society @J_A_C_S Congrats to all the authors for their contribution and work. #biochem https://t.co/I5dZ3Un6c9