Devin Fuller

-Cell Biology PhD Candidate at Yale University in the Melia Lab
-Research interests focus broadly on membrane remodeling with an emphasis in autophagy

[Devin Fuller @TheFullerLife64]

I'm excited to share a part of my PhD work with you! In this paper, we show that ATG2A localizes to rab1a containing early secretory membranes during autophagosome biogenesis. Following ATG2A/B deletion, these membranes coalesce with the rest of the biogenesis machinery.

[Cell Biology J-Club @cell_club]

ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis https://t.co/xQfHk6xMv0

[antisense. @razoralign]

SPEAR: A supervised bayesian factor model for the identification of multi-omics signatures https://t.co/PxRaoyCuhX

[Florian Schueder @FSchueder]

Please check out our (@bewersdorflab) latest work on #FLASHPAINT published in @CellCellPress.
#FLASHPAINT builds on #DNAPAINT and allows for fast and fluorogenic, highly multiplexed super-resolution imaging. https://t.co/RY4gvjPBoj

[Cell Biology J-Club @cell_club]

Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis https://t.co/LYLQb7iDPu

[Devin Fuller @TheFullerLife64]

Check out this fantastic work from my lab mate, Justin Korfhage @JLeonard_01! Justin demonstrates that ATG2A is capable of transporting lipids between phospholipid monolayers and bilayers and demonstrates that this activity is necessary for efficient lipid droplet regulation.

[Justin Korfhage @JLeonard_01]

I’m excited to finally share this project from the @TJ_MeliaLab where we demonstrate that the lipid transport protein ATG2 is active and highly efficient on phospholipid monolayers. (1/3)
https://t.co/pKqkbeXzCH

[Devin Fuller @TheFullerLife64]

Congratulations to my fantastic lab mate, @tjolivas! This compelling study beautifully demonstrates the residence of the sole transmembrane protein in the core autophagy machinery, ATG9A, on both progenitor vesicles and autophagosome membranes.

[Taryn Olivas @tjolivas]

It’s out! Exactly one week after my thesis defense, I’m so happy to share our (@TJ_MeliaLab) combined effort with @PDClab and @GuptaLab1 to show that ATG9 vesicles seed mammalian autophagosomes! We’ve added some cool data to the preprint, so check it out!

[Devin Fuller @TheFullerLife64]

The Baskin Lab strikes again! What a wonderful toolkit to study lipid transport in living cells. Fantastic!

[bioRxiv Cell Biology @biorxiv_cellbio]

Imaging interorganelle phospholipid transport by extended synaptotagmins using bioorthogonally tagged lipids https://t.co/A5mxIRu7Qb #biorxiv_cellbio

[Jeremy Gygi @JeremyGygi]

Today, I’m thrilled to share a preprint of our work describing SPEAR, a sparse supervised #Bayesian factor model for #multiomic integration:

https://t.co/Z6dLUihVMx

Follow along this #tweetorial to learn about SPEAR!
@YaleCBB
(1/🧵)

[Turk Lab @benturklab]

Truly excited that our collaboration with @CantleyLab and @LabYaffe, led by the mighty Jared Johnson and the unstoppable @Tomer_M_Yaron, to map substrate motifs for the Ser/Thr kinome is now out! Literally a project that spanned decades.
https://t.co/QgrTqawaNT

[Devin Fuller @TheFullerLife64]

Check out this fantastic study from Bulat Ramazanov and @LabVon! Bulat shows beautifully the necessity of calcium flux across the ER-TGN contact site to facilitate Cab45 mediated cargo efflux from the TGN. https://t.co/1JqWhA6nVr

[Graef Lab @GraefLab]

New transatlantic preprint🥳! A sensor-modulator subunit directly regulates the Atg1 kinase complex during phosphate starvation-induced #autophagy. Wonderful work from @Ansa_Lina and colleagues:
https://t.co/qDEFvy0FHD

[Devin Fuller @TheFullerLife64]

In the absence of PC synthesis, open cup-like structures accumulate, implicating PC as a key component in the closure of autophagosomes. 3/3

[Devin Fuller @TheFullerLife64]

Tom (@TJ_MeliaLab) and I recently had the privilege of highlighting recent work out of Elazar lab: check out our news and views article here! 1/3

https://t.co/zPUncMU31j

[Devin Fuller @TheFullerLife64]

In their recent article, Polyansky et al identify phosphatidylcholine (PC) as the most abundant lipid in the autophagosome membrane and demonstrate that eliminating de novo PC synthesis sharply impairs autophagic processing. 2/3

[Justin Korfhage @JLeonard_01]

Come hear my talk on Monday at 11:15 in room 201 where I’ll share my work demonstrating ATG2A mediated lipid transport at a phospholipid monolayer, and come find my poster at B432 #CellBio2022

[Devin Fuller @TheFullerLife64]

@mbeisen What if you paid the reviewers in APC credit? You would have to raise APC slightly, but it would incentivize researchers to review and to publish with journals for whom they review.

[IHG One Rewards @IHGOneRewards]

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[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Important news re. journal Aging Cell. Please distribute.

[Melia Lab @TJ_MeliaLab]

hey all, we would love to see some great cell biologists apply to the new Yale Science Fellows program! Pass the word around and note: 𝘼𝙥𝙥𝙡𝙞𝙘𝙖𝙩𝙞𝙤𝙣 𝘿𝙚𝙖𝙙𝙡𝙞𝙣𝙚 𝙣𝙤𝙬 𝙚𝙭𝙩𝙚𝙣𝙙𝙚𝙙 𝙩𝙤 𝙉𝙤𝙫𝙚𝙢𝙗𝙚𝙧 1𝙨𝙩!!!

[Devin Fuller @TheFullerLife64]

Amazing work from my lab mate @tjolivas! Taryn employs a combination of powerful biochemical techniques - membrane fractionation and styrene maleic acid extraction - to directly demonstrate that ATG9A and LC3B reside on the same membrane. Congratulations Taryn and fellow authors!

[bioRxiv Cell Biology @biorxiv_cellbio]

ATG9 vesicles comprise the seed membrane of mammalian autophagosomes https://t.co/dv4MrnKe0U #biorxiv_cellbio