Director NCI-designated Cancer Genome and Epigenetics Program at SBP, Co-Editor-in-Chief Aging Biology Journal, Road/Gravel/Mtn Cycling, Wolf Pack Cycling.
@LocasaleLab In last 20+ years - IPS cells, cloning, gene and stem cell therapy, immunotherapy, CAR-T, single cell techs, mRNA vaccines, CRISPR, RNAi, alpha fold, alpha genome, molecular glues, PROTACS, dark genome, spatial omics. All are transformative. Difficult to reconcile with your view.
As someone who works primarily on aging and cancer, I take your points about lifestyle, prevention, early detection etc…. But I still think the ability to finally inhibit RAS is an achievement and only the beginning of something with lasting impact.
@LocasaleLab Jason - I think the excitement over RAS inhibitors is that they are just the beginning. Similar to BRAF inhibitors and checkpoint inhibitors in melanoma 10-20 years ago. Surely melanoma is now in a much better place through these multiple incremental advances?
Another major advance vs cancer! @ASCO#ASCO26
Personalized neoantigen mRNA vaccine 5 year follow-up vs metastatic melanoma reduced recurrence and death by 49% (on top of Keytruda)
https://t.co/NadITTYIT2
📅 Save the date – October 22
Join us in Nice for the Workshop “Senescence & Immune Surveillance: Implications in Cancer and Aging”
🎓 Free participation – international speakers – lunch & networking!
#Senescence#Cancer#Aging#Immunology@ircaninstitute
New @ScienceMagazine
Why is the heart resistant to cancer?
Role of the heart beat!
Mechanical force helps protect the heart from cancer
https://t.co/ZaxGeRUbFN
@metapredict@agingroy Interesting. I’m surprised. But this agrees with you https://t.co/le088WcfX6 Very interesting. My intuition has been that exercise is at least good for healthspan in mid-late life.
Would be nice to have some functional measures to go with the clock data, but even so - seems like an exciting human study. Nice to see it coming from San Diego @UCSDHealth@MolinaLab1 Michael Corley and colleagues
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics
https://t.co/7q8gAZwwEw
@AlexanderMWolf7@UCSDHealth@MolinaLab1 That depends how you define “reverse aging”. For me, improvement in some functions does not constitute reversal of aging.
This seems similar to @skhosla78 senolytic trial - potential benefits most marked in those with high baseline markers. https://t.co/BEbwt3uYdz Patient stratification is important.
Congratulations @FarzadNegin@RongFan8 and coworkers! Leaders within @sennetresearch. This is a comprehensive documentation of senotypes in the lymph node, important to discern “good” and “bad” senotypes.
@davidjglassMD@CharlesMBrenner Congrats David. My family and I planned to go see it last week in NYC, but it was cancelled the night we had tickets. Shame😢. Next time.
@LidskyPeter@NatureAging For me, if there is a hierarchy, then dysregulated metabolism and dysregulated systemic homeostasis of endocrine/nutritional signaling are on top.
This is an excellent conceptualisation of epigenetics of aging. Takes a complicated topic and distills it down. Good to see histone H3.3 featured. For our latest contribution on histone H3.3 and aging see here https://t.co/CKQ532QRLl @NatureAging
This review is one of the most important syntheses in years. It doesn’t just catalog things. It proposes a unifying framework. ie. aging is a breakdown of epigenetic fidelity, the ability of cells to maintain correct gene expression over time...
@LidskyPeter@NatureAging Great question, Peter. I don’t think that epigenetics sits on top of a hierarchy of aging mechanisms, nor that epigenetic reprogramming is a cure for aging any time soon (specific pathologies maybe, as @davidasinclair is testing in humans).