Peter Adams🇪🇺🇺🇳

Director NCI-designated Cancer Genome and Epigenetics Program at SBP, Co-Editor-in-Chief Aging Biology Journal, Road/Gravel/Mtn Cycling, Wolf Pack Cycling.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

New road bike. S-WORKS Tarmac SL7, Campy SR wireless and disc, Campy Bora Ultra WTO wheels👍 No excuses now😧

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@LocasaleLab In last 20+ years - IPS cells, cloning, gene and stem cell therapy, immunotherapy, CAR-T, single cell techs, mRNA vaccines, CRISPR, RNAi, alpha fold, alpha genome, molecular glues, PROTACS, dark genome, spatial omics. All are transformative. Difficult to reconcile with your view.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@CharlesMBrenner @dr_ohsopretty Congratulations Charlie! Sounds exciting

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

As someone who works primarily on aging and cancer, I take your points about lifestyle, prevention, early detection etc…. But I still think the ability to finally inhibit RAS is an achievement and only the beginning of something with lasting impact.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@LocasaleLab Jason - I think the excitement over RAS inhibitors is that they are just the beginning. Similar to BRAF inhibitors and checkpoint inhibitors in melanoma 10-20 years ago. Surely melanoma is now in a much better place through these multiple incremental advances?

[Eric Topol @EricTopol]

Another major advance vs cancer! @ASCO #ASCO26
Personalized neoantigen mRNA vaccine 5 year follow-up vs metastatic melanoma reduced recurrence and death by 49% (on top of Keytruda)
https://t.co/NadITTYIT2

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@arjunrajlab @graveley 🤣

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Looks like a great meeting!

[Julien Cherfils @CherfilsJulien]

📅 Save the date – October 22
Join us in Nice for the Workshop “Senescence & Immune Surveillance: Implications in Cancer and Aging”
🎓 Free participation – international speakers – lunch & networking!
#Senescence #Cancer #Aging #Immunology @ircaninstitute

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@YounisJoseph 😂

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Super cool experiment. Activated Ras and inactivation of p53 in the heart = no cancer😂. Very interesting study

[Eric Topol @EricTopol]

New @ScienceMagazine
Why is the heart resistant to cancer?
Role of the heart beat!
Mechanical force helps protect the heart from cancer
https://t.co/ZaxGeRUbFN

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

I'm excited to speak at this meeting in Ireland in October this year. Looks like a great meeting! https://t.co/qOUJ6yavHM

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@metapredict @agingroy Interesting. I’m surprised. But this agrees with you https://t.co/le088WcfX6 Very interesting. My intuition has been that exercise is at least good for healthspan in mid-late life.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@metapredict @agingroy What’s the con? That exercise promotes healthy aging or the proposed mechanism?

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@AlexanderMWolf7 @UCSDHealth @MolinaLab1 Yes, that’s what I said in my original post

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Would be nice to have some functional measures to go with the clock data, but even so - seems like an exciting human study. Nice to see it coming from San Diego @UCSDHealth @MolinaLab1 Michael Corley and colleagues

[Aging Science News @AgingBiology]

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics
https://t.co/7q8gAZwwEw

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@AlexanderMWolf7 @UCSDHealth @MolinaLab1 That depends how you define “reverse aging”. For me, improvement in some functions does not constitute reversal of aging.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

This seems similar to @skhosla78 senolytic trial - potential benefits most marked in those with high baseline markers. https://t.co/BEbwt3uYdz Patient stratification is important.

[Daniel J Drucker @DanielJDrucker]

Revisiting changes in cognitive function and biomarkers of Alzheimer’s disease in REWIND https://t.co/2CDZ2fEm1n

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Congratulations @FarzadNegin @RongFan8 and coworkers! Leaders within @sennetresearch. This is a comprehensive documentation of senotypes in the lymph node, important to discern “good” and “bad” senotypes.

[Aging Science News @AgingBiology]

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches
https://t.co/OpM6QMWCjS

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@davidjglassMD @CharlesMBrenner Congrats David. My family and I planned to go see it last week in NYC, but it was cancelled the night we had tickets. Shame😢. Next time.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@LidskyPeter @NatureAging For me, if there is a hierarchy, then dysregulated metabolism and dysregulated systemic homeostasis of endocrine/nutritional signaling are on top.

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

This is an excellent conceptualisation of epigenetics of aging. Takes a complicated topic and distills it down. Good to see histone H3.3 featured. For our latest contribution on histone H3.3 and aging see here https://t.co/CKQ532QRLl @NatureAging

[Lifespan @JoinLifespan]

This review is one of the most important syntheses in years. It doesn’t just catalog things. It proposes a unifying framework. ie. aging is a breakdown of epigenetic fidelity, the ability of cells to maintain correct gene expression over time...

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

@LidskyPeter @NatureAging Great question, Peter. I don’t think that epigenetics sits on top of a hierarchy of aging mechanisms, nor that epigenetic reprogramming is a cure for aging any time soon (specific pathologies maybe, as @davidasinclair is testing in humans).