A ser(i)ous identity crisis: Metastatic breast carcinoma in pleural fluid
Malignant epithelial cells distinct from mesos (look for clusters, loss of polarity, nuclear pleomorphism ±nucleoli)
Intracytoplasmic vacuoles or mucin
Origin workup: GCDFP-15, mammaglobin, ER
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A middle-aged female patient with a brain lesion, known to be medically free.
In this case, what should be our initial thoughts? And what is the top differential diagnosis?
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(1)
Ecchordosis Physaliphora, a hamartomatous lesion of notochord remnants. IHC identical to chordoma. Unlike chordoma it 1) Benign 2) No growth potential 3) No lobular architecture #pathx#pathtwitter#neuropath#neuropathology#cnspathology
Seen in necrotizing granulation tissue in superficial arm mass of 20s F. Mysterious objects are lurking. Can you name them?
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