Structural Genomics Consortium (SGC)

A public-private partnership supporting the discovery of medicines through open science. Sharing our news, science and reagents!

[RSC Medicinal Chemistry @rsc_medchem]

Also in this month's issue is an update on Target 2035 from @CherylArrowsmi1, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035💡 Read the #OpenAccess article here⬇

https://t.co/tYFpV03cQm

[Structural Genomics Consortium (SGC) @thesgconline]

The AIRCHECK Workshop isn't just another conference! It is an exclusive opportunity to learn, experiment, and get ahead of the curve in ML/AI-driven hit discovery.

Register now: https://t.co/SPvAASEo5T

[Structural Genomics Consortium (SGC) @thesgconline]

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @UHN, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery.
Register here: https://t.co/SPvAASEo5T

[Structural Genomics Consortium (SGC) @thesgconline]

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @UHN, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery.
Register here: https://t.co/SPvAASEo5T

[Structural Genomics Consortium (SGC) @thesgconline]

@mattschap discusses how SGC will emerge as a leading source of open-science protein-ligand data and shares his vision for building stronger connections between data scientists and drug discovery experimentalists at the @UofT through the newly launched CrossTALK Bootcamp.

[U of T Data Sciences Institute (DSI) @UofTDSI]

Data science is driving breakthroughs in countless areas but a lack of availability of experimental training data has limited its impact on drug discovery.

Learn about the "Galvanizing Data Science Applications in Early Stage Drug Discovery" project:
🔗https://t.co/76fZkWcJD8

[Geordi Frere @geordifrere]

A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp @thesgconline in ACS Chemical Biology! They determine the appropriate doses of UPS pathway inhibitors that robustly rescue degradation without displaying off-target activity and toxicity.

[The Neuro @TheNeuro_MNI]

Researchers at @thesgconline and The Neuro, along with scientists from 11 major antibody manufacturers, have developed and standardized an #OpenScience platform to characterize research antibodies.

@YCharOS1 aims to tackle a critical challenge in biomedical research reproducibility.

🧪 https://t.co/kMKJ6q7DAp

[Structural Genomics Consortium (SGC) @thesgconline]

We co-hosted " @target2035 – A Public-Private Partnership to Accelerate Hit-Finding" along with @ucl and @pfizer. 50 leaders from the pharmaceutical industry, academia, and funding organizations discussed how AI and ML can transform drug discovery.

https://t.co/3Ak9LmngoI

[Albert A. Antolin (he/him) @antolin_aa]

#MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: https://t.co/xOsrQ1BFdq

[Structural Genomics Consortium (SGC) @thesgconline]

We just launched #MAINFRAME! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery.

Join us: https://t.co/oAcLGeaK3d

[JCIM & JCTC Journals @JCIM_JCTC]

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
https://t.co/knhE0jEpA9
@CherylArrowsmi1 @ian_dunn_ @aledmedwards @friedo91 @fgentile9 @olexandr @spiwokv @MKCMU @Sumera_Perveen @janhjensen @mattschap
#JCIM Vol64 Issue22 #compchem

[Structural Genomics Consortium (SGC) @thesgconline]

Supported by @UofTDSI, a program led by @mattschap
will provide trainees with the skills necessary to interpret complex experimental data and drive breakthroughs in drug discovery. Registration for the first 9-week bootcamp is now open.
https://t.co/HAA6Rse5rj

[Structural Genomics Consortium (SGC) @thesgconline]

New episode for our Target 2035 Podcast Series 🎧
@MilkaKostic talks with @aledmedwards to unpack his journey from a traditional research scientist to a passionate open science advocate.

Listen here: https://t.co/JUI5VWMQ79

[Structural Genomics Consortium (SGC) @thesgconline]

A summary of the efforts of @EUbOPEN, a public-private partnership dedicated to create, distribute and annotate the largest openly available set of high-quality chemical modulators for human proteins.
https://t.co/Owd7bmHF7I

[Structural Genomics Consortium (SGC) @thesgconline]

We have joined the Bluesky community! Follow us to stay updated on our latest research, collaborations, and efforts to shape the future of drug discovery.

https://t.co/4wAhd4Rsna

[Structural Genomics Consortium (SGC) @thesgconline]

How does EZH2 inhibition make atypical teratoid rhabdoid tumor cells vulnerable to therapy?
A collaborative study using UNC1999, a high-quality chemical probe developed through a collaboration between the SGC @UNCPharmacy.
https://t.co/oC6b3G3Wk7

[Structural Genomics Consortium (SGC) @thesgconline]

We report four DCAF1-based PROTACs with endogenous and exogenous WDR5 degradation effects and high-resolution crystal structures of the ternary complexes of DCAF1-PROTAC-WDR5.
https://t.co/VnyJoyl23V

#PROTACs #DCAF1 #WDR #DrugDiscovery #OpenScience

[Structural Genomics Consortium (SGC) @thesgconline]

A comprehensive study that offers validated ligands for future autophagosome tethering compound (ATTEC) development and advances targeted protein degradation strategies.
https://t.co/T6lXyRrexb

[Structural Genomics Consortium (SGC) @thesgconline]

A 2024 update on @Chemical_probes highlights a significant expansion in the number of chemical probes and human protein targets, along with major improvements in expert review processes and user engagement.
https://t.co/YfTclLB9qI

[Structural Genomics Consortium (SGC) @thesgconline]

A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK.
https://t.co/fg3lyssOpf

[Structural Genomics Consortium (SGC) @thesgconline]

A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease.

https://t.co/5P4SAMcmOy