Tommaso Perini

Physician scientist working on multiple myeloma @SanRaffaeleMI @MyUniSR. Passionate about cancer cell biology and its translational potential.

[Tommaso Perini @Tom_Perini]

🍾I am happy and proud to share with you the official publication of our latest results, now available in @BloodPortfolio
🔬Thanks to the application of in vitro and in vivo models, we show that ClpP is a metabolic and immunogenic vulnerability in #mmsm

https://t.co/eYYFPhLLTg

[Nikhil C. Munshi, MD @NikhilMunshiMD]

Very important new paper in JCO by Samur et al on SMM - will change our thinking! @VincentRK @NoopurRajeMD @szusmani @myelomaMD @SagarLonialMD @mvmateos @IrenemGhobrial https://t.co/KKjVDxan6W

[Tommaso Perini @Tom_Perini]

https://t.co/GmyiX1XmBp

[Tommaso Perini @Tom_Perini]

We are really proud to share our work on the role of ID2-TCF3 axis in myeloma!

Thanks @mtfulciniti and @NikhilMunshiMD for the amazing collaboration

[Robert Z. Orlowski @Myeloma_Doc]

#Myeloma Paper of the Day: ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3; BM milieu supports this by further decreasing ID2 expression & enhancing TCF3 activity, partly via IL-6: https://t.co/B2b4LGGAEG. #mmsm

[OncoDaily @oncodaily]

Myeloma Paper of the Day, October 18th, Suggested by Robert Orlowski (@Myeloma_Doc)

@BCD_AACR @mtfulciniti

https://t.co/aZt5ULR7ZM

#OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #MM #Myeloma @CancerWorldmag

[Tommaso Perini @Tom_Perini]

Thanks to all the amazing people involved, in particular to my phantastic co-authors Paola Zordan and @Bellone_lab
@Boletta_Lab @MMaterozzi @NikhilMunshiMD @StefanoniDavide

[Tommaso Perini @Tom_Perini]

🍾I am happy and proud to share with you the official publication of our latest results, now available in @BloodPortfolio
🔬Thanks to the application of in vitro and in vivo models, we show that ClpP is a metabolic and immunogenic vulnerability in #mmsm

https://t.co/eYYFPhLLTg

[Tommaso Perini @Tom_Perini]

💊We establish for the first time the proof of principle that targeting mitochondria can have a twofold effect in myeloma, both limiting cell growth and boosting anticancer immunity and the efficacy of novel immunotherpautics.

[VJHemOnc @VJHemOnc]

#EHA2025 It is always a pleasure to catch up with @ScarfoLydia! She spoke about all things CLL🩸

⭐️Updated findings on the BTK degrader BGB-16673
⭐️Optimizing frontline CLL treatment
⭐️The use of time-limited BTKi–BCL2i options

Coming soon to https://t.co/Vqyt4af67F📹

#Leusm #CLLsm #HemOnc

[Tommaso Perini @Tom_Perini]

A novel approach to degrade evil MYC in #mmsm presented #EHA25 !

Great job @maidom_ and all the team at Morelli lab and @NikhilMunshiMD lab!

[Tommaso Perini @Tom_Perini]

Brilliant work by @NikhilMunshiMD lab and great presentation by @ASchavgoulidze at #EHA25 !

These studies will hopefully pave the way for novel treatments for del17p #mmsm

[Tommaso Perini @Tom_Perini]

@MMaterozzi @Boletta_Lab @NikhilMunshiMD @StefanoniDavide @CiceriFabio

@MyUniSR @SanRaffaeleMI

[Tommaso Perini @Tom_Perini]

Our paper on a novel role for ClpP and mitochondria in #mmsm is finally out @BloodJournal !!
https://t.co/S4386p3Ptq

A special thank you to our amazing coauthors Paola Zordan and Matteo Bellone @Bellone_lab and to all the people involved!

Here is our discovery in just one 🖼️

[Tommaso Perini @Tom_Perini]

We found that without ClpP MM cells:
🛢️ do not produce enough polyamines, an oil for the cancer engine, and thus stop growing
🦠release mitochondrial DNA that is recognized as "bacterial" by cGAS-STING
🔥release immunogenic signals that boost anti-MM immunity

[Itai Yanai @ItaiYanai]

It’s crazy how talking with a science buddy is simultaneously what’s most likely to move the project forward and the thing that’s least prioritized in our schedule.

[Tommaso Perini @Tom_Perini]

So happy and honored for the opportunity to present my work on mitochondrial protease CLPP at #ASH24 !

Thanks for the support of all the friends and the positive feedbacks of great scientists!

Stay tuned for the complete story!

[Tommaso Perini @Tom_Perini]

Diet can work as secondary prevention in MGUS/sMM!
stellar @UrviShahMD

[Tommaso Perini @Tom_Perini]

Excited to be at #ASH24!!
Grateful for the opportunity to share our data and ideas on mitochondrial proteases in myeloma on Monday!

[Tommaso Perini @Tom_Perini]

Really wonderful talk as usual @vago_luca
Congratulations for your amazing work!
#ASH24