Tornero Lab

Structure of Macromolecular Assemblies Laboratory at CIB-CSIC
Interested in Cryo-EM, RNA polymerases and Transcription

[Tornero Lab @TorneroLab]

We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations.
Read more at @biorxivpreprint: https://t.co/nVwbVDEJn1

[Tornero Lab @TorneroLab]

You can now also find us at bluesky! https://t.co/L3B55Jc6wJ

[Ernesto Arias-Palomo @EAriasPalomo]

📢 El servicio de microscopía electrónica del @CIB_CSIC está buscando personas interesadas en solicitar un contrato #PTA2024.
📅 Fecha límite envío de expresiones de interés: 20/11/2024

Más info 👇
https://t.co/vu6Clv3ECK

[Tornero Lab @TorneroLab]

@NMITaylorLab @UCPH_CPR Congratulations, Nicholas!

[Tornero Lab @TorneroLab]

We're hiring! Are you looking for a PhD position in structural biology? We offer a fully-funded 4 year contract to study basic processes connected to transcription. If you're interested in joining us in sunny Madrid, get in touch with us!

[Tornero Lab @TorneroLab]

We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations.
Read more at @biorxivpreprint: https://t.co/nVwbVDEJn1

[Tornero Lab @TorneroLab]

@VanniniLab Thanks for the useful comment! Would be really cool to observe their presence in vivo too

[Tornero Lab @TorneroLab]

@vasan06 @biorxivpreprint @asantosaledo @4k4h1g3 Thank you!! :)

[Tornero Lab @TorneroLab]

We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations.
Read more at @biorxivpreprint: https://t.co/nVwbVDEJn1

[Tornero Lab @TorneroLab]

@Ella_Maru @biorxivpreprint @asantosaledo @4k4h1g3 Hi! The unique mechanism provides a strong signal for lesion repair that protects against undesired mutations in rRNA. The atomic details provided by our cryo-EM structures at several stages of the mechanism open avenues for therapeutic interventions. Hope that helps!

[Tornero Lab @TorneroLab]

@IsraelF96135088 Thank you, Isra!

[Tornero Lab @TorneroLab]

Have you ever heard of 11-subunit RNA polymerase I? We describe a structure lacking A12 in addition to A49/A34.5!

[Tornero Lab @TorneroLab]

We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations.
Read more at @biorxivpreprint: https://t.co/nVwbVDEJn1

[Nicholas M. I. Taylor Lab @NMITaylorLab]

We are delighted to see our review come out in @COSB_CRSB, where we review recent advances in the understanding of ion-driven rotary membrane motors.  Read it here:https://t.co/bOIaGZ9RXQ @UCPH_CPR (1/5)

[Tornero Lab @TorneroLab]

El pasado jueves estuvo Carlos en el #GoogleCloudSummitMadrid compartiendo nuestros últimos resultados, obtenidos con el apoyo de Alphafold, sobre complejos enzimáticos del parásito de la enfermedad del sueño: https://t.co/ZKkMHegRsB

[Llorca lab @LlorcaLab]

Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥

All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote

Link below 👇
https://t.co/vbRd2iEIHy

[Tornero Lab @TorneroLab]

We are very excited to share the structure of the T. brucei MCC and a putative activation mechanism! Out now in structure:
https://t.co/BpcaGCqvSI

[CIB Margarita Salas (CSIC) @CIB_CSIC]

Nuestro investigador Carlos Fernández Tornero escribe en @abc_es en relación a las ventajas y limitaciones del nuevo AlphaFold 3.
Puedes leerlo aquí 👇

[Tornero Lab @TorneroLab]

La publicación de #AlphaFold3 nos trae muchas oportunidades en el campo, especialmente para los que trabajamos en interacciones proteína-ácido nucleico. Carlos da unas pinceladas sobre su gran potencial, pero también sus posibles limitaciones, en @abc_es: https://t.co/RsJSsqK4El

[Tornero Lab @TorneroLab]

Check it out! We had a wonderful time working on this challenging enzyme:

[Structure @Structure_CP]

Online now! The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function https://t.co/V24zPnQae8

[Tornero Lab @TorneroLab]

We are very excited to share the structure of the T. brucei MCC and a putative activation mechanism! Out now in structure:
https://t.co/BpcaGCqvSI

[Tornero Lab @TorneroLab]

¡Damos la bienvenida a la nueva directora y vicedirectores! Agradecemos su labor al equipo saliente y tenemos muchas ganas de seguir trabajando de cerca estos años.

[CIB Margarita Salas (CSIC) @CIB_CSIC]

Damos la bienvenida a la Dra Pilar S. Testillano como nueva directora del @CIB_CSIC. La acompañarán como parte de su equipo, los vicedirectores Carmen Gil y Antonio Romero.