Llorca lab

Macromolecular Complexes in DNA Damage Response Group.
Structural Biology Programme @CNIOStopCancer

[Llorca lab @LlorcaLab]

starting to understand the structural bases of CONCR lncRNA in DNA replication and chromatid cohesion. A collaboration between @MaiteHuarteLab @FMorenoHerrero @OscarLlorcaCNIO @ChillonIsabel and the support of @FundlaCaixa

[Molecular Cell @MolecularCell]

Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion https://t.co/Vmpqvg6o2b

[Llorca lab @LlorcaLab]

A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with @sernarina, @DeBritoClaudia, Thomas Surrey and @LudersLab.
@CNIOStopCancer
@CRGenomica
@IRBBarcelona
https://t.co/EZhgKnuiKv

[Llorca lab @LlorcaLab]

Link to the paper: https://t.co/fQXCbJpm6Z

[Llorca lab @LlorcaLab]

Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP!

A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP .

Check it out in the next post 👇

[Llorca lab @LlorcaLab]

The γTuRC saga goes on!

This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator.

Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona.

https://t.co/0fEKmBGzQd

[Llorca lab @LlorcaLab]

Full info, speakers and registration deadlines in: https://t.co/31V6eI3KVx

[Llorca lab @LlorcaLab]

Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer

All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬

Org: @OscarLlorcaCNIO @rfleiro @NogalesLab

+info below 👇

[Ernesto Arias-Palomo @EAriasPalomo]

📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica
#PIF2024
+ info: https://t.co/XEIPbOFlJN
RT por favor 🙏

[Llorca lab @LlorcaLab]

Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗

Apply using the link below 👇 and help us spread the word!

https://t.co/XPMvlKdXsq

[Llorca lab @LlorcaLab]

And a movie with those beautiful high-res densities 🤓

[Llorca lab @LlorcaLab]

Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥

All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote

Link below 👇
https://t.co/vbRd2iEIHy

[Llorca lab @LlorcaLab]

And also... 🔥pre-print alert🔥

We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone.

A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP).

Check it out 👇

https://t.co/K1JUZL9rJI

[Llorca lab @LlorcaLab]

And here goes the link to the paper in @NatureComms 📰

https://t.co/fsr9vZC7gn

[Llorca lab @LlorcaLab]

🔥Paper alert🔥

Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇

A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter.

Supported by @FundlaCaixa

[david alabadí 🍊 dalabadi.bsky.social @AlabadiDavid]

Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇

[Llorca lab @LlorcaLab]

Double celebration today in the lab! 🎉

Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you!

#TodosContraElCancer @ContraCancerEs @ContraCancerMad

[Llorca lab @LlorcaLab]

🧬REGISTRATION OPEN🧬
✈️Come to the @CNIOStopCancer for our Molecular
Chaperones in Cancer and Protein Quality Control meeting.
☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!!

https://t.co/6s00b5YQQM

[Llorca lab @LlorcaLab]

🧬REGISTRATION OPEN🧬
✈️Come to the @CNIOStopCancer for our Molecular
Chaperones in Cancer and Protein Quality Control meeting.
☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!!

https://t.co/6s00b5YQQM

[Llorca lab @LlorcaLab]

@sernarina When your paper gets into @ScienceMagazine we take the red carpet out in the lab...

[Llorca lab @LlorcaLab]

PAPER ALERT🔥
We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way.
Proud of our collab with the @surrey_lab at the @CRGenomica !
https://t.co/Uu3fhaiIwc

[Llorca lab @LlorcaLab]

We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕