The γTuRC saga goes on!
This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator.
Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab@IRBBarcelona.
https://t.co/0fEKmBGzQd
Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer
All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬
Org: @OscarLlorcaCNIO@rfleiro@NogalesLab
+info below 👇
📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica
#PIF2024
+ info: https://t.co/XEIPbOFlJN
RT por favor 🙏
Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗
Apply using the link below 👇 and help us spread the word!
https://t.co/XPMvlKdXsq
Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥
All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote
Link below 👇
https://t.co/vbRd2iEIHy
And also... 🔥pre-print alert🔥
We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone.
A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP).
Check it out 👇
https://t.co/K1JUZL9rJI
🔥Paper alert🔥
Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇
A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter.
Supported by @FundlaCaixa
Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇
Double celebration today in the lab! 🎉
Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you!
#TodosContraElCancer@ContraCancerEs@ContraCancerMad
🧬REGISTRATION OPEN🧬
✈️Come to the @CNIOStopCancer for our Molecular
Chaperones in Cancer and Protein Quality Control meeting.
☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!!
https://t.co/6s00b5YQQM
🧬REGISTRATION OPEN🧬
✈️Come to the @CNIOStopCancer for our Molecular
Chaperones in Cancer and Protein Quality Control meeting.
☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!!
https://t.co/6s00b5YQQM
PAPER ALERT🔥
We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way.
Proud of our collab with the @surrey_lab at the @CRGenomica !
https://t.co/Uu3fhaiIwc
We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕
Primera ‘película’ a escala atómica de microtúbulos en construcción, un proceso clave para la división celular. El @CRGenomica, @CNIOStopCancer y @IBMB_CSIC resuelven un problema clave para la biología: cómo las células construyen sus microtúbulos.
▶️https://t.co/eGB86A0RQU