Rafa F Leiro

Structural Biology & Genome Integrity @ CNIO

[Xose R Bustelo @XRBustelo]

✅ Una medida excelente, que se venía demandando por todos aquellos que en algún momento participamos en paneles de evaluación del Programa RyC. @ASEICAnews @CienciaGob @ciccancer

[Lucas Tafur @structureltp]

Our latest manuscript is finally out in @NatureSMB!

Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.

https://t.co/EgW0fh2c0a

[CIB Margarita Salas (CSIC) @CIB_CSIC]

#cibjoboffer

Postdoctoral candidate to collaborate on a project that aims to understand the pathophysiology of mitochondrial disorders.

Deadline: February 28, 2026

More info 👇

[SEBBM @SEBBM_es]

Revista SEBBM 227 diciembre 2025

Dinámica conformacional del receptor GluA4: bases moleculares de su función y modulación por TARP-γ2

https://t.co/EYjykYTRPy

@BeatrizHergued1

[AlessandroBorsellini @ABorsellini]

Very happy to share a new preprint from my work in the @VanniniLab at @humantechnopole! https://t.co/eyEPUJDupD
If you are curious to understand what are the conformational changes that make human condensin II active in compacting the DNA during mitosis, have a read!

[BU_CNIO now in Bluesky: @bioinformatics.cnio.es @BU_CNIO]

#PorLaCiencia que hacemos en @CNIOStopCancer

[Rafa F Leiro @rfleiro]

@DawidZyla beautiful Dawid!

[Rafa F Leiro @rfleiro]

@IsraelF96135088 congrats!!

[Cortés Lab @CortesLab]

Our REPAIRome study finally out today in @ScienceMagazine !!!

https://t.co/LOJHQa4Yqe

[Cortés Lab @CortesLab]

Congratulations to all the people involved, also in @ChromDyn @rfleiro @gjmacintyre labs @CNIOStopCancer
Specially leading authors @ErnestoLDA1811 Israel Salguero and @DanielGLL_

Very proud of you!!!

[CNIO Stop Cancer @CNIOStopCancer]

@ScienceMagazine 🧬The human repairome, REPAIRome, will allow researchers around the world to check out how each of the 20,000 human genes affects DNA repair.

Authors: @CortesLab @ErnestoLDA1811 Israel Salguero Daniel Giménez et al. 

Funding: @CienciaGob @AgEInves @Europarl_ES

[CNIO Stop Cancer @CNIOStopCancer]

Researches at #cniostopcancer create the ‘human repairome’, a catalogue of DNA ‘scars’ that will help define personalised cancer treatments.
Published in @ScienceMagazine 

https://t.co/Fu0UIIhMF6

[Nayim GR @Nayimcete]

Our GPUs are always busy processing cool cryoEM data❄️, but we *really* wanted a to mess around designing protein binders.

To avoid swamping our cluster (and our colleagues complains 😅), we built a small batch-based binder design pipeline.

Hopefully you'll find it useful too!

[Rafa F Leiro @rfleiro]

We hope BinderFlow empowers more labs to explore generative protein design, making it a routine tool for both exploratory & production-level research.

Everything is open source:
https://t.co/GL07gSBCpe
Read the full preprint here:
https://t.co/OElkbCkETT

[Rafa F Leiro @rfleiro]

We present BinderFlow, a modular & automated pipeline that makes de novo protein binder design more accessible, efficient, and user-friendly.

Preprint by @Nayimcete, Twitterless Carlos, @LlorcaLab, and myself:
https://t.co/OElkbCkETT

Open source code:
https://t.co/GL07gSBCpe

[Rafa F Leiro @rfleiro]

BinderFlow is fully modular:
- Swap in new backbone generators, sequence designers, or scoring tools
- Add new strategies as they emerge

We illustrate this with two refinement approaches:
- Partial Diffusion
- Sequence Diversity

[Rafa F Leiro @rfleiro]

beautiful work!

[Israel Fernandez @IsraelF96135088]

Pre-print out from the @SternbergLab with our contribution on the structural side. Great effort from Matt, Egill Tanner and the rest of the team leaded by awesome Sam!
A 1 year effort on my side learning helical reconstruction by cryoEM... 👇