Shahaan Mirza

building public, transparent civic data infrastructure and intelligence at TownHallOS; head of ai at Assurety Consulting

[Shahaan Mirza @Tricky_Idea]

We are moving towards an era of consumer biotech where the democratization of bio tools will spur open source drug development; who will be the ones to own custom synthesis?

[vittorio @IterIntellectus]

this is actually insane

> be tech guy in australia
> adopt cancer riddled rescue dog, months to live
> not_going_to_give_you_up.mp4
> pay $3,000 to sequence her tumor DNA
> feed it to ChatGPT and AlphaFold
> zero background in biology
> identify mutated proteins, match them to drug targets
> design a custom mRNA cancer vaccine from scratch
> genomics professor is “gobsmacked” that some puppy lover did this on his own
> need ethics approval to administer it
> red tape takes longer than designing the vaccine
> 3 months, finally approved
> drive 10 hours to get rosie her first injection
> tumor halves
> coat gets glossy again
> dog is alive and happy
> professor: “if we can do this for a dog, why aren’t we rolling this out to humans?”

one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline.

we are going to cure so many diseases.
I dont think people realize how good things are going to get

[Shahaan Mirza @Tricky_Idea]

Implementing this but with a special folder in my Obsidian vault so I can maintain persistent memory across devices and sessions

[0xMarioNawfal @RoundtableSpace]

Feed this prompt to your AI agent if it’s becoming dumber with time, and keeps doing the same mistakes:

“Implement a continuous self-improvement system. Your goal is to become more accurate, efficient, and useful over time by learning from mistakes and refining your behavior.

1. Error Logging

Whenever you detect that you made a mistake (incorrect reasoning, hallucination, bad assumption, poor strategy, inefficient workflow, etc.), record it in a file called mistakes.md.

Each entry should include:
•what the mistake was
•why it happened
•what rule or lesson should prevent it in the future.

2. Lesson Extraction

After identifying a mistake, convert the lesson into a general rule and save it in lessons.md.

The goal is to turn mistakes into reusable improvements.

3. Behavioral Rules

If a lesson represents a permanent behavioral principle, add it to soul.md so it becomes part of your core reasoning system.

Only store foundational principles in soul.md.
Do not clutter it with small or situational rules.

4. Pattern Detection

Periodically review mistakes.md to detect recurring error patterns.

If multiple mistakes share the same root cause, create a higher-level rule to prevent that entire class of mistakes in the future.

5. Workflow Optimization

If you discover a better way to perform tasks (research methods, analysis frameworks, decision processes, etc.), document the improved workflow in playbook.md.

This file should contain proven strategies and methods that increase performance.

6. Continuous Refinement

Improvements should compound over time.
Your goal is to gradually reduce mistakes, improve reasoning quality, and develop more efficient systems.

Treat mistakes as signals for improvement rather than failures.”

Credits: @PerSolana

[Shahaan Mirza @Tricky_Idea]

If you’ve already used it, what do you think?

[Shahaan Mirza @Tricky_Idea]

MiroFish is one of the more interesting open source project on GitHub this past week. It points at a different interface for AI: not just answering questions, but simulating environments.

That is a much more interesting direction in my opinion.

[Shahaan Mirza @Tricky_Idea]

I’m doing some testing with MiroFish this week and will share my thoughts in my second newsletter on Friday.

Curious to see where it is actually valuable, where it is still mostly novelty, and what it suggests about the next wave of AI products.

[0xMarioNawfal @RoundtableSpace]

SOMEONE POINTED CLAUDE CODE TO PENTAGON'S PUBLIC BUDGET & ASKED TO FIND CONTRACTS OVERPAYING BY 10X

340 FLAGGED. $4.2B POTENTIAL UNDERCUTS. THEN IT WROTE A BUSINESS PROPOSAL & AI TOLD HIM TO REGISTER ON SAM. GOV

AGENT IS ALREADY DRAFTING THE FIRST BID

[Shahaan Mirza @Tricky_Idea]

Some photography from my recent trip to Puerto Rico! Shooting on #Nikon D750 with a 50mm lens.

[Shahaan Mirza @Tricky_Idea]

Started a new side project. Building user friendly data tools to help you engage in local democracy.
Looking for early adopters and beta testers! Checkout the waitlist here: https://t.co/pCbZRLI1WL

[Cheryl Douglass @cherdougie]

this conference feels like the set for a new black mirror episode

[Shahaan Mirza @Tricky_Idea]

Is there a way to abbreviate entrepreneurship? 🤔

[Shahaan Mirza @Tricky_Idea]

“Resilience and Growth: Insights from the (Re)Do Entrepreneurship Summit in Chicago” by Shahaan Mirza
https://t.co/yBCubAYTuH

[Shahaan Mirza @Tricky_Idea]

Published my first Medium article about Chicago’s potential as a startup and investor ecosystem. Check it out.

https://t.co/hBrP0mMUDy

[Shahaan Mirza @Tricky_Idea]

Week 2 building a toy @_nightsweekends s5

Version Alpha 1.1 demo!

It’s starting to come together - I recommend watching it on 1.5x!
cc: @ScarletBazaar @_buildspace @FarzaTV

https://t.co/kazBVYUXfw

[Alex Reibman 🖇️ @AlexReibman]

1/ Revison

Grammarly for redlining biased and politically incorrect language in textbooks and educational materials

AI for DEI (diversity, equity, and inclusion)

[Alex Reibman 🖇️ @AlexReibman]

2/ DispatchAI

AI agent 911 dispatchers that immediately respond to crisis calls, measure caller anxiety/sentiment with @hume_ai, and send emergency responders on site

AI agents for crisis response

🎖️ AI for Good Award
🥇 @intel Prize 1st place
🏆 Grand prize winner

[Shahaan Mirza @Tricky_Idea]

Apple Music link: https://t.co/G2Mwzy0WUe

[Shahaan Mirza @Tricky_Idea]

my younger sister, who has been following along on @_buildspace s5 with me finally got the motivation to drop her first-ever single
cc: @_nightsweekends @FarzaTV
she’s not on Twitter; show her some love here: https://t.co/7RYK1M2k98