Tyler Risom

Principal Scientist @Genentech. Employing highly-multiplexed imaging and novel digital pathology tools to reveal cancer’s vulnerabilities

[Tyler Risom @TyRisom]

Proud to be part of this large HTAN collaboration to understand the transcriptomic drivers of early breast cancer (DCIS) recurrence, out in this months @CancerCellMap ! https://t.co/Hv1Sy7bsaZ

[Tyler Risom @TyRisom]

Come join me this January in San Diego for a deep dive into the spatial biology underlying immuno-oncology

[Tyler Risom @TyRisom]

Congrats to @kausaliavbosse @BryJCannon for the first (of many) big study on neurodegeneration using MIBI! Beautiful work with the images and laying groundwork for non-cellular object segmentation 👏

[Bendall Lab @Bendall_Lab]

This is your brain on #MIBI. Thanks to the @NIHAging for funding this approach to study human neurodegeneration and aging.

[Tyler Risom @TyRisom]

@felixjhartmann Congrats Felix, she looks beautiful... excited to see the work!

[Tyler Risom @TyRisom]

@DrSpencerWatson @CellCellPress @MikeAngeloLab @NCIHTAN Thanks Spencer cheers bud!

[Tyler Risom @TyRisom]

Out today on the cover of @Cellcellpress! We created the first high-dimensional spatial atlas of breast cancer progression to understand why some patients with DCIS go on to develop invasive breast cancer while others do not. @Mikeangelolab @NCIHTAN https://t.co/88QEeS0cpm

[Olivier Elemento @ElementoLab]

Why do some patients with pre-invasive breast lesions progress to invasive breast cancer and not others? this single-cell multiplex imaging study from @MikeAngeloLab analyzed 433 spatial and compositional parameters, implicates myoepithelium and stroma https://t.co/sQSSSZurMJ

[Tyler Risom @TyRisom]

@SizunJ @MikeAngeloLab @ErinMcCaffrey14 Cheers Professor! Thanks for the support on the effort

[Tyler Risom @TyRisom]

@leeat_keren @MikeAngeloLab Thanks Leeat! Your work was foundational to the project, appreciate all the help. Cheers

[Tyler Risom @TyRisom]

@AmerCancerCMSO @MikeAngeloLab @ACS_Research @AmericanCancer Thank you Bill, and a huge thanks to the whole ACS fellowship team for their support on this project, keep empowering the postdocs!

[ACS Research @ACS_Research]

Beautiful cover, inspiring work, and a great tweetorial from former @AmericanCancer postdoc @TyRisom.

New in @CellCellPress: "Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma"
https://t.co/IkV2HMVOPA

[Tyler Risom @TyRisom]

@MaraShermanLab @CellCellPress @MikeAngeloLab @NCIHTAN Thanks Mara! Need a catch-up soon

[Tyler Risom @TyRisom]

@coussens_lisa Thank you Lisa, look forward to catching up soon

[Tyler Risom @TyRisom]

@claunch_cheryl @CellCellPress @MikeAngeloLab @NCIHTAN Thanks Cheryl!

[Tyler Risom @TyRisom]

@willgiardino Thanks Will 🍻

[Tyler Risom @TyRisom]

@ErinMcCaffrey14 Thanks Erin for the tongue in cheek accolades, couldn’t have done it without ya!

[Tyler Risom @TyRisom]

@ErinMcCaffrey14 @NatImmunol @MikeAngeloLab @purveshkhatri Amazing work Erin, beautiful images and even more impressive analyses. You’re a star

[Tyler Risom @TyRisom]

These findings suggest that myoepithelial decay in DCIS may actually initiate stromal and immune reactivity that provides a protective effect against recurrence! This work will hopefully lead to new prognostics that help women with low-risk DCIS avoid unnecessary surgery

[Tyler Risom @TyRisom]

To our surprise, we found that DCIS progressors had a more continuous, E-Cadherin-high myoepithelium, akin to the myoepithelial layer of the normal homeostatic breast. Further, this normal-like myoepithelium was associated with reduced immune density and desmoplasia in the stroma