tRNA at UCSC Lowe Lab

Lowe Lab @ucsc focuses our research on #tRNA, including gene prediction, sequencing, regulation, and #RNA modification.

[tRNA at UCSC Lowe Lab @UCSCtRNA]

Our method book chapter is out. Learn how to find and annotate #tRNA-derived RNAs from small RNA or tRNA sequencing data using our lab's in-house tools step-by-step.

Analyzing, visualizing, and annotating tRNA-derived RNAs using tRAX and tDRnamer https://t.co/M5vPduS9fk

[Trends Cell Biology @TrendsCellBio]

Stress-induced breakup: tRNA-derived small RNAs in biology https://t.co/PyHm5knQvR

[RNAcentral @RNAcentral]

🎉New RNAcentral paper published in Nucleic Acids Research! Discover automated literature integration, new expert databases, gene-level entries grouping related transcripts, and more: https://t.co/2Ndd5aoffC

[Rfam @RfamDB]

📢 Rfam 15.1 is here!

✨ 50 new RNA families including riboswitch candidates, plastid ncRNAs, snoRNAs, plant xrRNAs and more.
🧬 10 families updated with 3D structures
🖥️ Brand new interactive alignment viewer

Take a look https://t.co/9EOTwiFyow
#RNA #Bioinformatics #RNAbiology

[Zhou Lab @ZhouLabUCR]

In a new paper published today, we report a liver-enriched but overlooked small RNA as a key regulator of cholesterol homeostasis. This small RNA, tsRNA-Glu-CTC, could be a potential new target for treating liver disease and cardiovascular disease👇
https://t.co/Def2XO11sV

[Blood Journals Portfolio @BloodPortfolio]

TRMT5-mediated N1-methylguanosine tRNA modifications drive mitochondrial function and drug tolerance in AML via oxidative phosphorylation. Read the full article in Blood: https://t.co/Hqoo3QM06e

[Zeynep Baharoglu @BaharogluZeynep]

Happy to share our new review 🦠: tRNA-modifying enzymes in bacterial stress adaptation https://t.co/J3UxAV068h

[RNAcentral @RNAcentral]

🎉 RNAcentral Release 26 is here! This release introduces a significant structural change: gene-level entries for ncRNAs across 204 organisms.
For the first time, you can explore RNA data at the gene level, not just individual sequences. 🧵👇

[Zeynep Baharoglu @BaharogluZeynep]

tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, with TrhPO, from Haussler lab https://t.co/M6LXgcAer8

[Zeynep Baharoglu @BaharogluZeynep]

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks https://t.co/oJ7GThOwQY

[tRNA at UCSC Lowe Lab @UCSCtRNA]

@GuopingLi2 @ScienceMagazine @SaumyaDas_Lab @MGHanesthesia @mghcvrc Congratulations! It's great to be part of this collaboration!

[Guoping Li @GuopingLi2]

Our @ScienceMagazine paper is out! Discovered how tRNA-derived small RNA (tsRNA/tDR) protects kidneys via RNA autophagy. https://t.co/NpF0upRqMG
Huge thanks to @SaumyaDas_Lab and all our amazing collaborators!
Excited for the therapeutic potential ahead!
@MGHanesthesia @mghcvrc

[EMBL-EBI Jobs @EMBLEBIjobs]

🚨 @emblebi is hiring a Project Leader to shape the future of RNA resources! Lead RNAcentral & Rfam, collaborate with global experts, and drive innovation in RNA biology. Apply now: https://t.co/1lc6Hbdmru 🚀
#RNA #Bioinformatics #Genomics #DataScience #LifeSciences #EMBL

[RNA @RNAJournal]

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. https://t.co/hv3SfYZ0wH

[Jessica Tucker @JessTucker202]

https://t.co/Oq9F8ee9dK First big Tucker lab paper! Everyone in the lab made an appearance on the author list:) So proud and grateful for our collaborators and to the editors/reviewers for helping us improve the manuscript.

[Sebastian Glatt @GlattSebastian]

We are very excited about our latest work, which just came out @embojournal – https://t.co/fXvRgVMu1I. The work @MCB_UJ was driven by Anna Biela and @TingYuLin1031 in collaboration with Janusz Bujnicki and his team @IIMCB_Poland…a short🧵

[Mariusz Czarnocki-Cieciura @MariuszCzC]

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex.
https://t.co/VtfbOrx5u5

[tRNA at UCSC Lowe Lab @UCSCtRNA]

@HiteshTikariha https://t.co/yQNQzC98Hz is up running now.

[tRNA at UCSC Lowe Lab @UCSCtRNA]

Our method book chapter is out. Learn how to find and annotate #tRNA-derived RNAs from small RNA or tRNA sequencing data using our lab's in-house tools step-by-step.

Analyzing, visualizing, and annotating tRNA-derived RNAs using tRAX and tDRnamer https://t.co/M5vPduS9fk

[Malopolska Centre of Biotechnology UJ @MCB_UJ]

#NewPaper 🧬
A new review dives into the structural biology of tRNA modifying enzymes.
Authored by our scientists led by @GlattSebastian highlighting how cryoEM & crystallography reveal mechanisms behind key modifications.
Read here: https://t.co/y1gSA3TPyi
@JagiellonskiUni

[tRNA at UCSC Lowe Lab @UCSCtRNA]

Check out the new R2DT 2.0 paper and try it out https://t.co/hT0nkS4IQJ

It is great to be part of this project.

[Anton Petrov @AntonIPetrov]

🚀 New Paper Alert! 🚀

𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure

Check it out in @NAR_Open:
https://t.co/B9jkDWILg6

Here’s why you should give it a try 🧵👇