LoBeS - Lab of Brain eScience @ USC

Team of neuro and data scientists @USC using computational approaches, imaging & more to understand, predict & prevent brain disorders | PI @njahanshad

[Masoud Tahmasian, MD. PhD. @MasoudTahmasian]

🧠😴📝 New preprint from the #ENIGMASleep WG!
Led by @Harvey_Bi2333.
We pooled data from 7 international sites (n=2,372) to predict cognitive performance from demographics, sleep, and brain morphometry using #MachineLearning
📄 Preprint: https://t.co/Tgwrba9BRW

[Julio Villalón @JulioVillaln1]

We present the LARGEST normative model of the brain’s white matter microstructure: 54,583 subjects, 4-91 yrs, 19 datasets. We derived lifespan centile curves for DTI FA, MD, RD, AD, detecting anomalies for dementia, and Mild Cognitive Impairment: https://t.co/1xDgqXN9Ao ⤵️

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

@ImagingNeurosci Very nice! We also had a similar tool we published last year. Would be curious to compare
https://t.co/nkgPmRwI51

[Elizabeth Haddad @liz_haddad]

New preprint! 🧠 Mapping biopsychosocial and neuroimaging risk factors for dementia in MENA immigrants using UK biobank data (N=9,509). We identify key modifiable metabolic and environmental targets, providing a strategy for equitable dementia prevention. https://t.co/v7JCS8IqKe

[Lab of Neuro Imaging @USCLONI]

We’ve mapped the genetic blueprint of the brain’s largest communication bridge using a new AI tool developed here by @njahanshad & co. Our publicly available tool reveals how genes shape this vital structure & may influence certain disorders.
Learn more: https://t.co/CIKlLndbvb

[Integrative and Translational Neuroscience Lab @tendilla_lab]

Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA (@enigmabrains) Suicidal Thoughts and Behaviours consortium | @Transl_Psych
https://t.co/C69g0A1wS5

[Ravi R. Bhatt @ravirbot]

📢New paper out! “The Genetic Architecture of the Human Corpus Callosum and its Subregions" investigates how genetic variation shapes the size & thickness of the corpus callosum (CC) - the brain’s major bridge between hemispheres. #neuroscience #genetics @NatureComms

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

A huge congratulations to our long-time collaborator on all things AI, Professor Yolanda Gil, @yolandagil, for being appointed to the National Science Board!
https://t.co/pTWufwtklV

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

Current best practices and future opportunities for reproducible findings using large-scale neuroimaging in psychiatry: https://t.co/Q5mI2CPAol -- new review with @PersonomicsLab

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

In summary, this work identifies genome-wide significant loci of morphometry of the overall corpus callosum and its subregions, convergence on biological functions, tissues and cell types, as well as the genetic overlap with the cerebral cortex and neuropsychiatric conditions.

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

🚨Preprint alert!🚨"The Genetic Architecture of the Human Corpus Callosum and its Subregions" Meta-analysis of 46,685 European and replicated in 7,040 non-European ancestry individuals from the UK Biobank and ABCD studies.

https://t.co/YfXkUTGgaV

[LoBeS - Lab of Brain eScience @ USC @USC_LoBeS]

We observed negative global rG in CC area with ADHD and CC thickness with bipolar disorder (BPD). Positive local rG implicated the 20q13.33 cytogenetic band between posterior body thickness and BPD, and a negative rG at the C8orf89 gene between posterior body thickness and IQ.

[Thomas Nichols @nichols.bsky.social @ten_photos]

Thanks to all the speakers and attendees at the Neuroimaging Statistics Workshop, a satellite to #OHBM2024 in Seoul. Our program has been updated with slides from most talks in case you couldn't attend. Look out for NSW 2025 in Brisbane!
https://t.co/aifVLzOj2P