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An account for aggregating science news and shit talking on topics I know little about. Basically, an account for learning.

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@Bio_youtuber Mechanisms of action are bedtime stories we tell ourselves to keep the existential truth at bay; that, in the end, it’s impossible to understand the implications of molecular complexity on human health.

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@returnofaj That guy had such an ironically negative overreaction to a very mild criticism of Lehky’s recent play. Strange.

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@AppleHelix A big ego is a prerequisite…the whole system is built on prestige-seeking. Combine that with the field being incredibly competitive and selective pressure does the rest.

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@ProducerDrew_ He was really good at 4 Nations…but not sure how he fits

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@AppleHelix ah ok. So Vinay thinks trialists are influenced negatively, and you think they’re the star MDs.

I think you’re both right.

Still, if I’m just getting standard of care for a commonly occurring cancer, I would go with a competent but not star MD. Why risk ego coming into it?

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@AppleHelix It’s good to try experimental medication? I wouldn’t want to. Chances are I’d get massive side effects and no benefit. Even if you would, pretending like untested experimental medication is a magical panacea is weird.

[Max Unfried @MaxUnfried]

Us not understanding biology is the main reason why most of drug development ends in failure.

[Joseph Marine @DrJMarine]

I remember an inspiring lecture that Dr. Collins gave shortly after he discovered the CFTR gene in 1989. He should have stuck to molecular genetics and avoided opining in epidemiology, public policy, foreign relations, and pandemic management. Weighed against his great accomplishments in his own field will be his negligent oversight of gain-of-function research and poor leadership of NIH during covid.
He could have promoted evidence-based medicine, funded more RCTs to test countermeasures, and sponsored diverse panels of experts to publicly debate elements of the covid response. Instead, he promoted govt propaganda, dogmatism, and censorship over science.
If the NIH is going to recover from the covid debacle, it will need to sweep out the entire old guard and replace them with younger leaders who recognize how profoundly the US biomedical establishment failed during the pandemic and who are committed to fundamental reform. https://t.co/02fChSP6zC

[FormerlyGenentech @3Lz3Lo3A]

I am fully convinced 80% of oncology-focused biotechs could disappear and nothing of value would be lost.

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@Joshilabyale scihub

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@DrMorganLevine @MitoPsychoBio There’s no evidence that APP mutations are the same biological entity as idiopathic AD or models the disease in any meaningful ways.

It’s all just a tangled knot of bad ideas.

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@AvsRobin We need a R Dman. Already need one.

We traded De Haan for Lindgren. Down one more.

Now we’re trading Manson?

Make sense?

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@JFreshHockey $4.5 million is craaazy

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@Biotech2k1 The timing and intensity of Recursion’s media blitzes has always been curious

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@iskander Oh so this was a marketing exercise. I knew it seemed like a weird result but didn’t care to read the paper. Turns out it wasn’t a scientific paper at all, just a fancy marketing paper in a medical journal.

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@JFreshHockey @Shae_Nuge93 algorithm’s broken

[iceberg ❄️🏔 @snowset]

Reading, and in particular, reading poetry and literature, is a technological process to strengthen the heart.

⬇️This is like saying riding a stationary bike is pointless because you can commute to work in your car.

[Perry Demsko @nandgatesonly]

The fact that in the wake of NIH cuts universities are gutting graduate admissions rather than trimming administrative bloat is very telling.

Either they cannot be trusted to spend money properly, or they are making a political statement by directly affecting prospective student's lives.

Neither is a good look.

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@landysknee They have a deal in the works and need that $2 million