BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Interested in 3' UTR changes in scRNA-seq? Check out our:
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
https://t.co/XXYEBHV1iG
We propose ctQC(https://t.co/hm2OfLoDqs), a data-driven method to filter low-quality cells from scRNA & spatial omics data! Apart from empty droplets it efficiently eliminates soup/debris & damaged cells improving downstream biological inferences. Comments & suggestions welcome!
We finally wrote up our cell type-specific QC (ctQC) protocol for scRNA (and spatial)-seq data: https://t.co/KLDzc77ZH9 . Comments welcome! In a nutshell: we show that sc QC cutoffs should be strict, cell type-specific and data-driven. 1/
Check out the tweetorial for more details - https://t.co/Y7DWyPk5i7 ! Huge thanks to Shyam for all the discussions throughout this work and special thanks to @iaintan_mdphd for co-supervising! I would like to thank all @shyam_lab members, @astar_gis & NCCS.
Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling https://t.co/N619EGEFgc. Let’s have a quick look!
Many of us use GFP all the time in lab, but have you ever wondered what fluorescent proteins do in nature? I’m delighted to share our paper (https://t.co/0KPvBbNQHV), hot off the presses, where we uncover new roles for FPs in intertidal sea anemones.
Curious? Read on: 🧵1/n
1. BANKSY is out! https://t.co/uy8myuVA5p
Our spatial clustering algo applies to any spatial RNA/protein/... assay, scales to 2M cells, detects both cell typing and spatial domains and facilitates spatial batch correction.
🧵 👇
🔊Start the week right with a fresh episode! 🔊This month @BaidSrishti joins us, sharing her insight & tips on navigating an international career move 🇮🇳✈️🇺🇸We also discuss how some of the challenges of a big
move can intersect with being #womeninSTEM ⬇️
Don't miss it! 🧵1/2
Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA https://t.co/JG1mzYvLgb
RIBOmap for spatially resolved single-cell translatomics is published today! Congrats to the whole team and thanks so much for the constructive feedback and great suggestion from the editor, reviewers, colleagues, and friends!
https://t.co/Dmxbe7atn5
Congratulations Dr. Srishti Baid!!! Fantastic (and incredibly energetic) dissertation defense - on to post-doc at University of Michigan with David Ginsburg - so very proud of her!! @KUbiology @kuhotZmicro @KUMolBio @DyanMorgan @BaidSrishti
Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature https://t.co/eIAn8MW6jN