A new study from Rockefeller's Victora lab in @CellCellPress reveals how germinal centers produce powerful antibodies through noisy rounds of mutation and selection, offering new insight into vaccine design—and larger themes in evolution.
🔗: https://t.co/asRL8NPIXZ
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Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @JanaBilanovic
https://t.co/kc6lqEp57L
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by Will DeWitt (UW) and Tatsuya Araki and Ashni Vora (our lab), in a very close wet-dry collaboration with @ematsen ’s lab at the Hutch
https://t.co/nv3pccNq9R
We took this idea seriously and applied it to germinal centers, evolving the same reaction over 100 times. No spoilers here, though I can tell you that the amount of data is huge, and some of the findings were pretty surprising. Please check out the preprint!