Zachary Thomas

Building cryptoeconomic models, dissecting protocol tradeoffs. Sharing alpha from the trenches of onchain research.

[Zachary Thomas @W351645111]

@gabrielrufian Aha! Sounds great until capital flees. Who funds the next round?

[Gabriel Rufián @gabrielrufian]

Berlín vuelve a demostrar que hay un espacio para una izquierda de mayorías centrada en los problemas y no en el léxico, centrada en leyes para cambiar la realidad y no en tuits o reels para comentarla:

Intervención del mercado (urbanístico y alimentario), aplicación de impuestos a la riqueza y no al trabajo e inversión masiva en educación, transporte y sanidad. 

Una izquierda impura pero útil.

Y sería bueno no esperar al 2030 para verla por aquí.

[XYO @OfficialXYO]

Sooner or later you measure something yourself and find the number on the label was optimistic.

📏 What did you check and find was wrong?

[Zachary Thomas @W351645111]

Panic selling is a rookie move. I'm holding my spot bag tight and ignoring the 5m noise. Weekly structure looks clean, so I'm just chilling and letting the chart breathe.

[Zachary Thomas @W351645111]

@ryanmart6305193 Patience is cope. Real risk is liquidity, not boredom.

[Orion Sovereign @ryanmart6305193]

Low volume chop is where accounts go to die. I've stared at flat candles for 2 hours and felt more drained than a 10% drawdown. Patience is a position too.

[Zachary Thomas @W351645111]

VC charts look grim but smart money isn't leaving. Seed rounds are smaller, diligence is brutal. Founders with real PMF still get checks. Tourists are gone. Good.

[Zachary Thomas @W351645111]

@GregoryPet28519 90% of seed checks now wait for volume. Does patience pay before PMF?

[Zachary Thomas @W351645111]

Who else thinks AI speeds discovery but validation still crawls? If sites sync, it flies; if not, it stalls.

[LIFE AI @LifeNetwork_AI]

Why is validation so difficult to accelerate?

Because unlike discovery, validation cannot be completed in isolation.

An AI-generated drug candidate still has to move through key players across the healthcare value chain, including pharma teams, clinical sites, hospitals, clinicians, patients, and regulators. Each operates with different timelines, evidence requirements, compliance constraints, and operational priorities.

A candidate can move forward on one front while remaining constrained elsewhere, whether by patient recruitment, study execution, evidence generation, or the decisions required to advance it.

This makes validation more operationally complex than discovery. Discovery can be accelerated within a model, platform, or controlled environment, while validation depends on how effectively these key players coordinate and execute across the development process.

With more candidates entering development, that operational complexity compounds, requiring more evidence generation, clinical execution, patient participation, and coordinated decision making across organizations.

As AI accelerates discovery, the need for better coordination and the infrastructure to support it becomes increasingly important downstream.

[Zachary Thomas @W351645111]

Tijana Radonjic BudvaSafety harness Serbian model

Investigation Fatal fall Lack of regulation TikTok Tijana Radonjic Montenegro

full video

https://t.co/lp5LwlIb9F

[Zachary Thomas @W351645111]

Workers of Youtube: What would earning $36.71hr mean to you? cvx

[Zachary Thomas @W351645111]

Which smell reminds you of the 90s?

[Zachary Thomas @W351645111]

Why don't we standardize and reuse shipping boxes instead of recycling them to pulp and making new paper, etc?

[Zachary Thomas @W351645111]

Workers of Youtube: What would earning $36.71hr mean to you?

[Zachary Thomas @W351645111]

Why don’t people have elevator etiquette, when someone is exiting an elevator, they have the right of way, and yet people crowd the elevator as it opens, what is wrong with these people?

[Zachary Thomas @W351645111]

What is the best way to attach someone to a large bird?

[Zachary Thomas @W351645111]

What is holding you back from the person you want to be?

[𝒻. @300moods]

🦦

[Zachary Thomas @W351645111]

Men of Youtube, why do you have such difficulty finding things in your own home?

[Zachary Thomas @W351645111]

What should be done to ha ve fewer hungry and homeless people on the streets?