Wen-Xing Ding

scientist study autophagy, alcohol and non-alcoholic fatty liver disease & DILI

[eGastroenterology @eGastro_BMJ]

🧐 Friend first, foe later?

🆕 Newly formed megamitochondria may help the liver adapt to alcohol—but chronic accumulation can impair mitochondrial quality control ⚠️, promote inflammation 🔥 and contribute to liver tumorigenesis 🧫.

📖 Read more: https://t.co/zF4qcGedL4

#ALD #LiverCancer #Mitochondria

@Gut_BMJ @BMJ_Open @FrontGastro_BMJ @BMJOpen_Gastro

[eGastroenterology @eGastro_BMJ]

🚀 A major milestone for eGastroenterology!

📈 Impact Factor: 10.5
🏆 JCR Q1
📊 Ranked #11 of 153 journals in Gastroenterology & Hepatology
🌍 Top 7% worldwide

We extend our sincere gratitude to our Editors-in-Chief, Editorial Board, Youth Editorial Board, reviewers, authors, readers, publishing partner BMJ Group, and academic supporter the CALS for their invaluable support.#Gastroenterology #Hepatology #OpenAccess
@bmj_company @emadelomar @gaobinge @wxding1 @BoeckxstaensLab @l_suthat @gabriel_oniscu @GSzaboMD @Tacke_lab @XinWang77

[Wen-Xing Ding @wxding1]

@jclinicalinvest @KUMedCenter More than 7 years hardworking from talented student Xiaowen and postdoc Xiaoli and Mengwei. Thanks our collaborators Hiromi etc. Megamitochondria accumulation leads to impaired mitophagy and cGAS-Sting activation that promotes liver tumorigenesis.

[Journal of Clinical Investigation @jclinicalinvest]

In the 1960’s, #megamitochondria in hepatocytes were identified in injured liver tissue.

Here, Wen-Xing Ding @wxding1 & team @KUMedCenter find alterations in mitochondrial dynamics and the accumulation of large mitochondria contribute to #liver #tumor development in mice: https://t.co/xGOMX8RkUv
# MASH

The EM image shows liver cells with megamitochondria (arrows) from mice lacking liver-specific dynamin-related protein 1 (Dnm1).

[eGastroenterology @eGastro_BMJ]

🍺🍔What is MetALD—and why does it matter?
US NIH’s Prof. Bin Gaoleads a 🌍 global team of 20+ international expertsto deliver a landmark review on Metabolic dysfunction & Alcohol-associated Liver Disease (MetALD)
🔍 Clear concepts
⚙️ Mechanistic insights
⚠️ Key research & clinical challenges ahead

📖 Open access🔗https://t.co/i6TAugjZuD
#MetALD #LiverDisease #Hepatology #MASLD #ALD #NIH #OpenAccess
@gaobinge @juanpabloarab @l_suthat @wxding1 @GSzaboMD @MehalWajahat @rabataller @FrankTacke @Gut_BMJ @FrontGastro_BMJ @BMJOpen_Gastro @BMJ_Open

[AASLD @AASLDtweets]

✌️ Days Away! Don't miss part ☝️ of our three-part webinar series, Intro to #AI in #BioMedicine, Thursday at Noon EDT.

Register for one, two, or all three sessions! https://t.co/eHtSn9kjqo

[AASLD @AASLDtweets]

Join us next Thursday at Noon EDT for part ☝️ of our three-part webinar series, Intro to #AI in #BioMedicine.

Register today for one, two, or all three sessions! https://t.co/eHtSn9kjqo

[The American Journal of Pathology @AJPathology]

#CallforPapers

@AJPathology seeks your research into Alcohol Induced Organ Damage for our next theme issue.

Submission is free and can be done online: https://t.co/2ApQwt8AhB

[AASLD @AASLDtweets]

Join AASLD's Hepatotoxicity Special Interest Group (SIG) for this month's seminar Gut-liver Crosstalk Mediated by the Bile Acids-FXR-FGF15/19 Pathway on February 13 at 11:00 AM ET. https://t.co/jMWFo5Muu3

[Lily Dara @lilydaramd]

Join us this Thursday Jan 9th 11am EST/8amPST @AASLDtweets #Hepatotoxicity SIG seminar " Using human biomimetic liver microphysiology system and quantitative systems toxicology models to study MASLD and DILI" presented by Drs. Vernetti & Miedel, from @PLRC_PittLiver Register here: https://t.co/YiU6pG2GMN

@livertox @wxding1 @TFFVIIa @electedmaux410 @jacobbogdanovmd @LaylaShojaie @nagachalasani @DeHalegoua @audayan @ChrisKohMD @DrPMonga @DavidKleiner12 @RobertFontanaMD @jonnysexton @rajVuppaLanchi @sidbarritt4 @GinaChoiMD @BurcinEkser

[Wen-Xing Ding @wxding1]

@PLRC_PittLiver @DrPMonga @AASLDtweets Congratulations Dr Michalopoulos! Well deserved! Very lucky to have worked at Pitt Pathology.

[Jim luyendyk @TFFVIIa]

You don’t need to know each detail
Just know prizes may land in your email
Whether he knows it or not
David Kleiner’s your bot
If you win, he records your new….voicemail

Also there are coffee mugs. 😁
@DavidKleiner12 @AASLDtweets

See you all at Wait Wait…

[Wen-Xing Ding @wxding1]

Great first day with great science on alcohol associated liver disease: 3rd Johns Hopkins DELTA Center Symposium on Alcohol-associated Hepatitis:
Pathogenesis, Treatment and Challenge

[Wen-Xing Ding @wxding1]

@MizLabUT Congratulations Noboru!

[Wen-Xing Ding @wxding1]

Full article: Quality control of mitochondria involves lysosomes in multiple definitive ways https://t.co/WDpUp1avfk

[American Society for Investigative Pathobiology @ASIPath]

Registration, abstract submission, and award applications are open for #Pathobiology2025! Join us in Portland, OR next April for fantastic science 🔬 https://t.co/RUMMoWPmLd

[Wen-Xing Ding @wxding1]

Further information and registration details can be found here: https://t.co/OzQidSR5GN

[Wen-Xing Ding @wxding1]

a great opportunity to get together for meeting at DC for alcohol related liver disease research: great line up of outstanding speakers, great location, great season and great food…..

[Wen-Xing Ding @wxding1]

@TFFVIIa @audayan @pritchardmt @DrXLongZheng Thanks for coming back. We and students really enjoyed your visit

[Livers MDPI @LiversMdpi]

#mdpilivers
Welcome to read the paper "Targeting #Autophagy for #Acetaminophen-Induced #LiverInjury: An Update".

Free full-text:
https://t.co/Inss4UmP8h