Zhao Lab

BRCA tumor suppression network | DNA damage repair | Ubiquitination

[Zhao Lab @WXZhaoLab]

@BasserBRCA @PennCancer A big congratulations, Carman!

[Cortés Lab @CortesLab]

Check out our web tool to see interactive networks of DSB repair genes, browse your gene of interest for its contribution to DSB repair profiles and analyze functional relationships based on similarities in repair patterns

https://t.co/BE3pHpdqBE

Enjoy!!!

[Dr. Kaia Mattioli @kaia_mattioli]

Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%).

🧵1/ …

[Molecular Cell @MolecularCell]

Online Now: PALB2 and 53BP1 govern post-resection homologous recombination DNA repair https://t.co/ac49AMzLtU

[Zhao Lab @WXZhaoLab]

@RogerRogergr @BasserBRCA @PennCancer @PennMedicine @PennMDForum Can it open for postdocs from other universities?

[Roger Greenberg @RogerRogergr]

@BasserBRCA @PennCancer @PennMedicine @PennMDForum This is a great opportunity!

[Roger Greenberg @RogerRogergr]

Join us in beautiful Ventura for the 2025 GRC meeting, Mammalian DNA Repair: Fundamental Mechanisms to Human Biology https://t.co/92pKBd6q0n…… Great program, including keynotes from David Pellman and Maria Jasin. We will be selecting talks and poster slots soon. Apply now!

[Zhao Lab @WXZhaoLab]

@jstarklab Congratulations!

[Roger Greenberg @RogerRogergr]

Assistant and Associate Professor positions available at UPENN's Basser Center for BRCA . Great opportunity to be part of an amazing scientific environment.
Assistant Level:  https://t.co/U15zUBg2le
Associate Level : https://t.co/UyCDhdhmnA

[Francesca Cole @ColeFrancesca]

I love this fundamental discovery science success story! Curiosity driven research birthed a new era of molecular medicine - congratulations and well deserved Drs. Ambros and Ruvkun! We need discovery and curiosity to remain a foundation of science.

[UT Southwestern Medical Center @UTSWMedCenter]

#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. https://t.co/q7NWqorgja @LaskerFDN

[nature @Nature]

Nature research paper: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection https://t.co/eCsxid14UW

[nature @Nature]

Nature research paper: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination https://t.co/q0hht2Lsuv

[Zhao Lab @WXZhaoLab]

@CejkaLab Their argument is resistance comes often from other unstudied pathways, not the well known ones. In this logic, the only important thing is to know whether they function in the pathway, no need to go deeper how they works in a great detail. How would you argue with it?

[Cejka Lab @CejkaLab]

When overseeing grant review applications, one particularly grumpy reviewer pointed out why we should care about a mechanism when we know the approach works in the clinics. Exactly, why bother understanding how the engine works when the car still moves—until it doesn’t.

[Zhao Lab @WXZhaoLab]

I like their analogy—what a wonderful explanation of our research!

[Zhao Lab @WXZhaoLab]

Thank you so much for promoting our work from V foundation. https://t.co/YnJ568gO0Y

[Zhao Lab @WXZhaoLab]

@hou_xiaowei Thanks, Xiaowei.

[Zhao Lab @WXZhaoLab]

Really excited to share this work led by Yuxin Huang and Wenjing Li. It reveals novel DNA binding activities located in HDOB1 of BRCA2, but it has to be “shut off” by DSS1 for proper BRCA2 activity. https://t.co/8ZlMC8ybDN

[Zhao Lab @WXZhaoLab]

We are looking for 2 postdocs for many exciting projects on BRCA1 or BRCA2, please contact me if you are interested in joining our team.