Bar-Even Lab

We study and engineer microbial metabolism for a green economy. Account run by PhD students and postdocs of the lab.

[Bar-Even Lab @WeTheBarEvenLab]

AG Bar-Even For-Ever #dott

[Sebastian Wenk @SebWenk]

Amazing job by a whole gang of previous AG Bar-Even members @WeTheBarEvenLab who converted E. coli into glyoxylate growth biosensors for enzyme engineering!

[Helena Schulz-Mirbach @mirbachh]

Harnessing the high product titers from fermentations for aerobic productions? Metabolic rewiring makes that possible! Read below to get to know my NNmini strain allowing the selective use of respiratory modules to re-balance unbalanced fermentations!

https://t.co/GheBBjW5Xh

[HaiHe @haihe10]

Happy to share our curated medium-scale E coli metabolic model out. We believe it has many application potentials, a few demonstrations shown in our preprint https://t.co/jaxUYJsUwv check it out. Great job by Marco! #Synbio #metabolism @WeTheBarEvenLab

[Víctor de Lorenzo @vdlorenzo_CNB]

Citius, altius, fortius: Automated in vivo enzyme engineering accelerates biocatalyst optimization 👇 https://t.co/obBqYUp9yg

[Lennart Schada von Borzyskowski @LennartSchada]

How can lab automation, machine learning, and high-throughput screening methods be combined to speed up the enzyme engineering process? We address this question in a new article in @NatureComms, out today: https://t.co/6QnCcqKrcx

[Enrico Orsi @enricoorsi]

This nice work is the result of a team effort involving experts of different aspects of the whole workflow: @LennartSchada, Stephan Noach, @PabloINik and @SteffenNLindner. We believe that this can be a useful read to synbio, enzymologists and automation experts! (n/n)

[Pablo Iván Nikel @pabnik.bsky.social @PabloINik]

#Automated in vivo #enzyme #engineering accelerates #biocatalyst optimization — Led by @enricoorsi & @SteffenNLindner w/@LennartSchada & Stephan Noack @NatureComms #SynBio #CellFactory
https://t.co/6VaJzvAeTN

[Lennart Schada von Borzyskowski @LennartSchada]

We propose to combine machine learning with automated workflows and efficient selection processes in engineered bacteria to address challenges in enzyme engineering. By following this integrated approach, we aim to engineer enzymes faster and more reliably than before.

[Enrico Orsi @enricoorsi]

Obtaining efficient #catalysts is one of the core challenges of #bioengineering. However, combination of existing #SynBio, #computation & #automation techs can boost the way we generate these catalysts.

Check this 🧵 to learn more! (1/n)

https://t.co/s6WOi7GO3o

[Nico Claassens @NicoC_MicSynBio]

Very happy I was awarded this week the ' Kluyver Award' by the board Royal Dutch Microbiology Association (@KNVM_online ) for my contribution (or better our!) to microbiology, sustainable biotech, teaching and mentoring activities. Thankful to many advisors, colleagues, students

[Mary Pavan @MaryPavan]

I am not crying, you are crying! What a special beginning of day 2 @CRecycle_Net ❤️❤️❤️ @WeTheBarEvenLab

[Bar-Even Lab @WeTheBarEvenLab]

Great group and great science! Check out this #postdoc opportunity in Berlin together with former core members of @WeTheBarEvenLab 🫶

[Bar-Even Lab @WeTheBarEvenLab]

Finally out the work led by @VRBysani and @FabianMachens about the engineering and evolution of the rGP to support formate-to-pyruvate conversion in S. cerevisiae!
Check it at the link: https://t.co/plC1OnzJXA

[Bar-Even Lab @WeTheBarEvenLab]

🚨#preprint alert! Functional reductive glycine pathway in #yeast!
Have a look at our work where @VRBysani, Ayesha, Arren & @FabianMachens successfully demonstrated formate-to-pyruvate conversion while assimilating CO2 in Saccharomyces cerevisiae!
🧬🦠♻️
https://t.co/ojvm75Dt9Z

[Viswanada Reddy Bysani Kondagari, Ph.D. @VRBysani]

I am happy to share our publication demonstrating the functional Reductive Glycine Pathway (RGP) in S. cerevisiae, presenting evidence for nearly complete glycine and serine flux and partial pyruvate flux from formate coupled with CO2 co-assimilation is recently published.

[Nico Claassens @NicoC_MicSynBio]

Very cool to see this work out! Another promising new to nature/not yet discovered in nature C1 fixation pathway from the @WeTheBarEvenLab led by @haihe10 @TongWu_C

[HaiHe @haihe10]

Happy to share our new design of a C1/formaldehyde assimilation pathway out on @NatureComms. Congrats to @TongWu_C and all. Thanks to supports from @WeTheBarEvenLab, Philippe Marliere, @SteffenNLindner, and @erblabs! #MetabolicEngineering #SynBio https://t.co/2Hw0mIWXsY

[IMPRS-μLife @IMPRS_Mic]

Congratulations to @mirbachh on winning the add-on #fellowship of the Joachim Herz Stiftung! Helena plans to use the fellowship to gain additional computational expertise which would help to systematically find bottlenecks in engineered synthetic #CO2 fixation by E. coli.

[Enrico Orsi @enricoorsi]

🚨New paper! In our article, together with @PabloINik, Lars Nielsen and @BioSteDonati, we discuss current state of investigation of #natural and #synthetic C1-trophic bugs, proposing that these approaches can synergistically help each other's👇🧵[1/n]
https://t.co/mJQjIfavqx

[Stefano Donati @BioSteDonati]

📢The C1 Metabolism group @DTUBiosustain is recruiting! We are looking for a Postdoc (https://t.co/gR0fkC4TwE) and a Research Assistant (https://t.co/D5YsGrBsvO) to join us in our mission to understand and engineer microbes that grow on C1 substrates. Please share!

[Pablo Iván Nikel @pabnik.bsky.social @PabloINik]

3 years ago we lost an amazing person and great scientist, but his legacy still lives on in the community he left behind—@WeTheBarEvenLab organized an elegiac yet cheerful homage to Arren as his group moves onto new endeavors. Honored to be part of this extended family🌱