Willsey Lab

Lab of Jeremy Willsey, Associate Professor @ UCSF

[Willsey Lab @WillseyLab]

Congrats @ShengWangD on your recently published work, which establishes a clear contribution of rare variants on Chromosome X to male-biased psychiatric disorders and identifies a new X-linked high confidence autism gene, MAGEC3.

https://t.co/8SQmWNL2f4

[UCSF Psychiatry and Behavioral Sciences @UCSFPsychiatry]

New UCSF-led research reveals the complex interplay of #genetic factors contributing to male-biased prevalence in #autism spectrum disorder, #Tourette syndrome, and #ADHD, paving the way for future advancements in #neurodevelopmental disorder research.

https://t.co/W5FSIZ44YT

[Willsey Lab @WillseyLab]

And as always, this work would not have been possible without all of the patients and their families that so generously participated in this research #Autism #tourette #ADHD

@UCSFPsychiatry @SFARIorg @Spectrum @TouretteAssn @CHADD_ADHD

[Willsey Lab @WillseyLab]

Congrats @ShengWangD on your recently published work, which establishes a clear contribution of rare variants on Chromosome X to male-biased psychiatric disorders and identifies a new X-linked high confidence autism gene, MAGEC3.

https://t.co/8SQmWNL2f4

[Willsey Lab @WillseyLab]

Thanks to everyone in the @WillseyLab, especially @belinda_p_wang and @snw555, as well as our fantastic collaborators, including Vanessa H. Bal, Gary Heiman, Jay Tischfield, Thomas Fernandez, and Matthew State.

[Martin Kampmann @MartinUCSF]

Excited about our new pre-print - investigating the impact of autism-linked genes on neuronal differentiation.

https://t.co/6qkjFGERpW

Co-led by @WillseyLab @snw555 and @KampmannLab @noamteyssier & @RuilinSUSTech.

Read Noam's tweetorial here:

[Noam Teyssier @noamteyssier]

Very excited to present our recent preprint! This was a massive effort over the past three years that investigates the complex biology of high-confidence ASD (hcASD) genes during early timestamps of neurogenesis using single-cell CRISPRi.
https://t.co/juHC9hE4rx

[Willsey Lab @WillseyLab]

@UCSFPsychiatry

[Willsey Lab @WillseyLab]

Congrats Nawei and Noam for conducting the largest CRISPR-based screen of high confidence autism risk genes conducted to date. Follow the link for more details!
@snw555 @noamteyssier @belinda_p_wang @fimazaltsman @MartinUCSF @UCSF @Spectrum @SFARIorg

https://t.co/Hp8hCkTsb9

[Willsey Lab @WillseyLab]

@pcmi

[Willsey Lab @WillseyLab]

Thanks to our many collaborators, especially Matthew State @rhuttenhain , @LabNowakowski , @goodfrognosis , and the rest of the @pcmi

[Willsey Lab @WillseyLab]

Congrats @belinda_p_wang , Rasika, @fimazaltsman , @SnowNaing1 and the rest of the team for creating a comprehensive map of the protein-protein interactions of 100 high confidence autism genes

@WillseyLab @KroganLab @UCSFPsychiatry @Spectrum @SFARIorg

https://t.co/1VY70wiIJP

[UCSF Psychiatry and Behavioral Sciences @UCSFPsychiatry]

Jeremy Willsey, PhD, highlights the potential of targeting interacting proteins, opening doors to treatments benefiting larger groups of autism spectrum disorders patients. A step towards more effective clinical trials.

https://t.co/aZIJUG1X7w

[Willsey Lab @WillseyLab]

Check out our new preprint quantifying the contribution of rare X-linked genetic variation to three male biased neurodevelopmental conditions: autism, Tourette syndrome, and ADHD https://t.co/b3ST1q9fFz @UCSFPsychiatry @QBI_UCSF @PsychCellMap @ucsfrrtp @SFARIorg @spectrumnewsorg

[UCSF Psychiatry and Behavioral Sciences @UCSFPsychiatry]

Recent studies, by @goodfrognosis, A. Jeremy Willsey, @belinda_p_wang & Matthew W. State, have gained insights on compounding genetic risks for autism spectrum disorder and are closer to developing therapeutical interventions. @WillseyLab
🧬https://t.co/gZzfYPwso2🧬

[Willsey Lab @WillseyLab]

@RMeyerSchuman Thank you!

[Willsey Lab @WillseyLab]

@WalentekLab @NatRevNeurosci @goodfrognosis @belinda_p_wang @UCSFPsychiatry @QBI_UCSF @PsychCellMap Thanks Peter, hope you are doing well! We think of you often.

[Willsey Lab @WillseyLab]

Proud to have our review paper published online today in @NatRevNeurosci

Also feel very fortunate to have such wonderful co-authors in @goodfrognosis @belinda_p_wang and Matt State

@UCSFPsychiatry @QBI_UCSF @PsychCellMap

https://t.co/z5WI1rmLfD

[UCSF Psychiatry and Behavioral Sciences @UCSFPsychiatry]

Studies have identified a growing list of associated risk factors for autism, and—with the use of gene editing tools, multidimensional omics datasets, and higher-throughput model systems—possible therapies. @goodfrognosis @belinda_p_wang @WillseyLab
🧬https://t.co/ISCSGkn8Xn🧬

[Nature Rev Neurosci @NatRevNeurosci]

Genomics, convergent neuroscience and progress in understanding autism spectrum disorder – a new Review by Helen Rankin Willsey, A. Jeremy Willsey, Belinda Wang & Matthew W. State
@goodfrognosis @belinda_p_wang @WillseyLab @UCSFPsychiatry @UCSF

https://t.co/0i87vMKEPi

[Willsey Lab @WillseyLab]

And special thanks to @ShengWangD for his tireless work in creating and revising Figure 1!