WredenbergLab

Mitochondrial research at the Division for Molecular Metabolism, Karolinska Institute @wredenberglab.bsky.social

[WredenbergLab @WredenbergLab]

Our study on how mitochondrial methylation shapes gene expression is now out. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Read all about it at: https://t.co/PJHQNPTEKm

[WredenbergLab @WredenbergLab]

Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI.
https://t.co/JWQpbvLDX4

[Paulina Wanrooij @PaulinaWanrooij]

Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA.
https://t.co/7y4I61KuSN

[Mito@GU @Mito_at_GU]

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
https://t.co/dN8YmvxHom

[WredenbergLab @WredenbergLab]

Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI
For the PhD position: https://t.co/9ZsHC4RbqJ
For the PostDoc position: https://t.co/MOBdoUy10K

[Hansong Ma @Hansong_Ma]

Check out our recent paper showing how maternal inheritance of mtDNA is guaranteed in D. melanogaster.

[Pagliarini Lab @Pagliarini_Lab]

I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others.
https://t.co/4gnU2DgaG4
#mitochondria
#HHMINews

[Hauke Hillen @hauke_hillen]

The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments!
https://t.co/CckIvTOOxX
See also the very nice related work by @BMartinHallberg @no1gv: https://t.co/FOcw8tVQv0

[Aleksandra Filipovska @FilipovskaLab]

New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!

https://t.co/0eH1tbkKDA
#RNA
#mitochondria
#mtDNA

[WredenbergLab @WredenbergLab]

@Ella_Maru @labs_mann @NatureComms @metaboflo That’s a good question that our fly model can’t answer. Our data indicates that the chronic and excessive activation of autophagy contributes to mitochondrial dysfunction. Whether this also drives the age-related mitochondrial decline we will test in a different model system.

[WredenbergLab @WredenbergLab]

We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo
https://t.co/xLNyW00oil

[WredenbergLab @WredenbergLab]

We performed a genetic screen in fruit flies and identified several pathways that can rescue a lethal phenotype of mtDNA mutator flies. Looking forward to testing this in a higher species.

[WredenbergLab @WredenbergLab]

We argued that since the accumulation of mtDNA mutations is progressive, there must be cellular mechanisms that affect their pathogenicity.

[WredenbergLab @WredenbergLab]

Just over a week left to apply for a PostDoc position in mitochondrial biology with us. #mitochondria @mitojobs
https://t.co/tOv2e06nxd

[WredenbergLab @WredenbergLab]

We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs
https://t.co/tOv2e05PHF

[WredenbergLab @WredenbergLab]

Using nanopore RNAseq and cryoEM on SAMC KO MEFs and skel muscle we show that SAM is crucial for mt-rRNA processing and mitoribosome assembly. #mitochondria.

[WredenbergLab @WredenbergLab]

Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI.
https://t.co/JWQpbvLDX4

[VilleKaila @TheKailaLab]

Extremely proud to share our integrative work on how 'Dissected antiporter modules establish the minimal proton-conducting elements in Complex I' – now out in Nature Comms! Many thanks to @KAWstiftelsen & @Vetenskapsradetfor funding. https://t.co/Vek2ZIlUoq

[Diana Rubalcava @RubalDiana]

🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: https://t.co/uEqZ2l9757

[WredenbergLab @WredenbergLab]

Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with @taylorlabncl and @lukas_k

https://t.co/Vak11bWg0F

[Roberta Filograna @RobertaFilogra2]

We are excited to share our lab's first preprint, highlighting the role of the CHCHD2-CHCHD10 complex in preserving tissue homeostasis.
A huge thank you to all our collaborators!
https://t.co/21K1yuwd5H