Gusvan

Synbio, Liverpool FC, Chinese Poem, Photography

[Patrick Hsu @pdhsu]

Delighted to share a landmark preprint from our lab, using genome language models and AI agents for biological discovery and genome mining!

The stretches of DNA between protein-coding genes are often called the genome’s “dark matter,” but they are far from empty. They encode RNA molecules that sense metabolites, regulate genes, and control some of molecular biology's most important tools (such as programmable genome editors e.g. CRISPR/bridge)

Much of this biology is unexplored. One reason is that RNAs can retain similar structures and functions even as their DNA sequences change dramatically, making their relationships difficult to recognize with conventional computational tools

[Michael C. Jewett @MichaelCJewett]

Teaching synthetic biology?

This Article about the @ElowitzLab repressilator features an interactive chart, and allows you to play around with the circuit's parameters.

https://t.co/ALOICcoOjM

[Tom Ellis @ProfTomEllis]

Meet 𝐋𝐢𝐥𝐚 - an Automated Scientist built by the Amyris crew to do E.coli and Yeast metabolic engineering by DBTL cycles. Lila has made 100s of biosynthesis strains. Perhaps she is going to make your PhD students feel a bit sad
https://t.co/QHKw55jILh

[Manuela Casasoli @manuelacasasoli]

If you love #biochemistry like me and enjoy learning biochemical pathways... Well, this is for you!

#Science
#biology

Thanks to @Roche

⏯️Metabolic Pathways
https://t.co/opi1aCy75y
⏯️Cellular and Molecular Processes
https://t.co/cB3wlpnGaH

[Gusvan @XufanGuo]

Walking on the ice

[Joseph Watson @_JosephWatson]

DALL-E’s amazing images are popping up all over the web. That software uses something called a diffusion model, which is trained to remove noise from static until a clear picture is formed.

Turns out diffusion models can design proteins too!

[Gusvan @XufanGuo]

@Michell25852120 emmm...我接种过，还打过加强针，但是只在本省的防疫app上能查到，换个地方扫健康码就显示未接种疫苗

[Gusvan @XufanGuo]

@WeiwuerXW 怪谁？小区物业没有对消防通道进行清理，如果是防疫人员占用或者批准被隔离人员的车辆临时占用，那就处罚防疫人员。如果开发商没有预留足够通道，那就开发商买单。
至于铁桩，应该是防止乱停车安装的，是否合理？是否也是开发商和物业来买单？

[Olivier Borkowski @O_Borkowski]

Biosensor-based therapy powered by synthetic biology
https://t.co/3NhVNVuRQV

[Gusvan @XufanGuo]

fall in love with signal towers
#tower

[Gusvan @XufanGuo]

@avtytla Theirs shall be the best answer😂

[Gusvan @XufanGuo]

秋风清
秋月明
秋日私语
道古今

[Mo Khalil @MoKhalilLab]

1/n PAPER ALERT: In collaboration with @davidrliu, we combined eVOLVER + PACE (= ePACE) to facilitate the evolution of compact Nme2Cas9 variants that can target single-nucleotide (previously-inaccessible) PAM sequences for precision genome editing.
https://t.co/mcbWaB199Q

[Nature Chemical Biology @nchembio]

Work by @simonsnitz, @alperlab, Andy Ellington & colleagues evolves a general transcription factor into specific biosensors for various alkaloids, enabling streamlined production of tetrahydropapaverine. Free to read link at https://t.co/gwnzQl9An3

[Nature Reviews Methods Primers @MethodsPrimers]

New this week! In vivo continuous evolution takes advantage of cycles of rapid mutation, amplification and selection inside living cells @cnb_csic @CSIC @Beatriz_Al_Go @lafdez_synbio @chang_c_liu @haiqi_chen @UTSWScience @francesarnold @zerlinia

https://t.co/wXxdiwXlvE