Simon dOelsnitz

Synthetic Biology Fellow @harvardmed
Genetic sensor engineer

[Simon dOelsnitz @simonsnitz]

Our chemical -> biosensor prediction tool, Ligify, just came out in @ACSSynBio !

Give it a spin: https://t.co/Bv5Iv8Rcuu
Publication here: https://t.co/6ql3mniMXC

[Simon dOelsnitz @simonsnitz]

Just hit 150 biosensors in groovDB!
https://t.co/L9x1Lf568i

[Simon dOelsnitz @simonsnitz]

Neat video from Research Square about our recent biosensor/ML paper
https://t.co/3CCZYlPJYU

[Simon dOelsnitz @simonsnitz]

... Matthew Minus for chemical synthesis, James Howard for LC/MS analysis, Mason Schechter & Hannah Do for cloning support, and Hal Alper @alperlab & Andy Ellington for general support/advice.

[Simon dOelsnitz @simonsnitz]

Our paper on biosensor/ML-aided enzyme engineering just came out!

We're one step closer to fermenting the anti-alzheimer's drug Galantamine, rather than harvesting it from daffodils.

https://t.co/biINga2YnR
@synbio

[Simon dOelsnitz @simonsnitz]

This was a huge TEAM effort.
Thank you Danny Diaz and James Loy for creating/implementing MutComputeX, Wantae Kim and Jessie Zhang for enzyme crystallography, Daniel Acosta for HPLC measurements, Tyler Dangerfield for kinetic analysis, ...

[Simon dOelsnitz @simonsnitz]

Excellent updated review on TetR-family transcription factors. #synbiosensors
https://t.co/wkBfETEUhk

[Simon dOelsnitz @simonsnitz]

Development of a whole-cell biosensor for ethylene oxide and ethylene
https://t.co/MQ8Q1LIOt1

[Simon dOelsnitz @simonsnitz]

Snowprint is out!
Find out what specific DNA sequence your biosensor recognizes. #syntheticbiology
https://t.co/c6KBEza8Kc
https://t.co/ImUNc52ztC

[Simon dOelsnitz @simonsnitz]

Transcription factor evolution plasmid (pSELIS) is now available on Addgene. https://t.co/o3PQJVduhO

[Simon dOelsnitz @simonsnitz]

Preprint of our new tool for predicting biosensor-DNA interactions is out. We use it to discover sensors for a cannabinoid precursor, among others. Check it out!
https://t.co/jkqHkJLdYJ

[Simon dOelsnitz @simonsnitz]

Can #synbio help us brew an Alzheimer's drug currently harvested from daffodils? Just got 1 step closer. 🌼🧠🦠
https://t.co/W6hX3QHXFg

[Inyup Paik, Ph.D. @InyupPaik]

Now we know what is the rate limiting step in LAMP, which will enable even faster diagnosis of diseases via LAMP. https://t.co/PMxuxLQV9b

[Simon dOelsnitz @simonsnitz]

@Moon_Synth_Bio @ACSSynBio Glad to hear! We are working hard to improve it further.

[Simon dOelsnitz @simonsnitz]

Big thanks to Josh Love and @aiproteins for making this possible!

[Simon dOelsnitz @simonsnitz]

Tired of searching the literature for genetic sensors? Check out our biosensor database (https://t.co/T2If9cQlr2), now published in @ACSSynBio
https://t.co/xYX1YplZIy

[Simon dOelsnitz @simonsnitz]

Just put out a pre-print on a database of genetic biosensors I put together (https://t.co/u9HeyZvJlb). Hope it's useful to the syn bio / bioengineering community! Feel free to message me with feedback.

https://t.co/Wk3KwmnR0k

[Simon dOelsnitz @simonsnitz]

+1 biosensors, -1 chromatography! My work on evolving biosensors for therapeutic alkaloids is now out in @nchembio
https://t.co/wlGmjsIE3J
#synbio #biotech #biosensor

[Simon dOelsnitz @simonsnitz]

Recently published in @ACSSynBio !
https://t.co/0ohn5049Ba
#scicomm

[Simon dOelsnitz @simonsnitz]

Terpenes are hard to measure. Genetic biosensors can help. Here, we evolve biosensors responsive to fragrant monoterpenes.
#biotech #synbio #biosensor #directedevolution

https://t.co/dnN92ouRBI