A vaccine combining alum-anchored antigen and saponin adjuvant increases clonal expansion and clonal diversity of germinal center responses in mice
https://t.co/DXheAlk57W @ScienceTM
We found that antigen deposition on follicular dendritic cells is the key in driving strong germinal center response. | Science Translational Medicine https://t.co/OsbUyhJHmO
Who's up at BATS?
Y. Cui (White) MHC-I Associated Antigen Presentation at Tumor:immune Interface in Glioblastoma
Y. J. Zhang (Irvine, Love) Investigating the Impact of Vaccine Formulations on Humoral Immunity via Integrated Single-cell Multi-omic Analysis https://t.co/bJd8PTrN6z
Such a great experience being in the 5050 cohort. You'll be surrounded by brilliant, hard working people creating solutions to the world's biggest problems. The 5050 team is insanely supportive in helping scientists navigate the deep tech founder journey. 10/10 recommend
NIH grants frozen. Discoveries delayed. PhDs pushed out. Academia getting gutted.
Innovation must continue. There’s never been a better time for scientists to build startups.
Spent a fantastic weekend at #MITHackingMedicine@mithackmed
In 48 hours, we tackled taboo topics of sexual & reproductive health. From physical prototyping to developing business models, our solution is bold, innovative, and practical. Love my exceptional team ❤️
It’s a great honor to give an oral presentation on our efforts in creating novel vaccination strategies for HIV at #CROI2024@IAS_USA Wish to thank my advisor Prof. Darrell Irvine for the incredible mentorship and encouragement @MITdeptofBE@kochinstitute
Kicking off 2024 by sharing a preprint of my PhD work! We report an engineered cytokine therapy that elicits some of the most profound anti-tumor immunity we have seen in our labs' preclinical work.
Preprint and walk-through below:
Please join us in congratulating the Nanoscale Horizons and Nanoscale Advances poster prize winners from #nanoDDS 2023! 🏆 @Y_Jason_Zhang, Patricia Nagai de Lima and Serena Omo-Lamai 👏👏 you can find out more about them in our latest blog 👇
https://t.co/znpygoI0T9
Prof Darrell J. Irvine was elected to the National Academy of Medicine for 2023 “for the development of novel methods for delivery of immunotherapies and vaccines for cancer and infectious diseases.” https://t.co/njpECSY3mQ @theNAMedicine
Inspiring and vibrant experience at the #NanoDDS2023 Fortunate to be selected as one of the Best Poster Award recipients with my labmates from the Irvine and Love Labs 🧬 Many thx to the organizers ❤️ @kochinstitute@MITdeptofBE@MIT
@a_dobin Thank you for such an amazing tool! Wondering if you guys are planning to publish it as more ppl in the community are using it. It’s been on BioRxiv for more than 2 years
Prof Darrell Irvine Lab's new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. https://t.co/VV3zGBYw4p @CellCellPress@LeyuanM@kochinstitute@ragoninstitute
Human autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, while the congenital mouse model has a non-homologous mutation in Cys1 gene. In this article, we demonstrated the first reported connection between Pkhd1 and Cys1.
https://t.co/KFtdss7y5Z
Prof Christopher A. Voigt will be the next head of the MIT Department of Biological Engineering. Learn more about Prof Voigt at https://t.co/D3r0GRvBBn @Geneticdesigner
BE professor Michael Birnbaum strives to prepare his students for success, from day one of graduate school through embarking on an enriching career path. https://t.co/AxcfoXj10a @MEBirnbaum
BE faculty Linda Griffith @LindaGGriffith1 and Feng Zhang @zhangf elected to the National Academy of Medicine for 2021. Election to @theNAMedicine is considered one of the highest honors in the fields of health and medicine https://t.co/ILZ8f9umN8