Mandel-Gutfreund Lab

Computational Molecular Biology @Technion @biologytechnion

[Technion Israel @TechnionLive]

🌟 Viruses vs. Human Cells: The Evolutionary Arms Race🧬
Technion researchers uncover a unique mechanism in human cells that rapidly activates the immune system against viruses. A breakthrough in fighting infections and understanding evolution! 🔬🧬 Study in @NatureComms led by Prof. Yael Mandel-Gutfreund & @AArgoetti of @BiologyTechnion
#Biology #Immunology #TechForHealth

https://t.co/He6RlQOi1L

[Mandel-Gutfreund Lab @YaelmgLAB]

We’re thrilled to share our new paper! 🎉
This study reveals how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response.

Congratulations to Amir and the entire team for their incredible work!

@BiologyTechnion @TechnionLive
https://t.co/NNeBvibq1n

[Amir Argoetti @AArgoetti]

1/7 I’m excited to share our paper, describing the majority of my PhD, now published in @NatureComms!
We present how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response in human cells. A 🧵

[Amir Argoetti @AArgoetti]

Does anyone know of a gorilla cell line?
And if so, does anyone in Israel have one and is willing to give us a vial?

[Amir Argoetti @AArgoetti]

אני יודע, פה זה לא אינסטוש, אבל אפיתי בגטים לכבוד החברה הצרפתיה שלי @GaliaPolyak שמציגה בעוד כמה שעות את המאסטר הסופר מוצלח שלה ואני מאד גאה בה!

ואם אתם במקרה בטכניון היום ב12:30, מוזמנותים לשמוע על RNA רגולטורי בהתפתחות עוברית (ולטעום מהבגטים 😉)

[Amir Argoetti @AArgoetti]

Hi RNA feed!
Does anyone here know of a small-molecule or non-protein RNAse inhibitor?

All the RNase inhibitors I found are large proteins that can disrupt my assay

[Victor V. Lobanenkov @boris_ctcf]

🍰The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense https://t.co/vqkSIDWLYP

[Amir Argoetti @AArgoetti]

In summary, a surprise twist in evolution unlocked NORAD's new feature!
It can now mediate the nuclear entry of STAT3, thereby inhibiting the interferon response in primates.
Upon viral infection, NORAD is cleaved, prompting STAT3's exit and activating the antiviral response.

[Amir Argoetti @AArgoetti]

Unfulfilled with its conserved partnership, NORAD found a new match...

Please welcome our preprint on how an ALU element equipped NORAD in the arms race against viruses!🧵

The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense
https://t.co/B10AlIz6ZX

[Gal Haimovich ☣ 🔬🎗 @grnfluoresceblg]

cool!
should be useful

[Mandel-Gutfreund Lab @YaelmgLAB]

RBPmap is back!

If you need an accurate prediction of RBP binding sites, look no further >>

https://t.co/gvm8lsWJNM

@BiologyTechnion
@TechnionLive

[Mandel-Gutfreund Lab @YaelmgLAB]

@EnsenyatMiquel Fashionably late....

Good luck!

https://t.co/7VGZMZ2Vhk

[Mandel-Gutfreund Lab @YaelmgLAB]

RBPmap is back!

If you need an accurate prediction of RBP binding sites, look no further >>

https://t.co/gvm8lsWJNM

@BiologyTechnion
@TechnionLive

[Mandel-Gutfreund Lab @YaelmgLAB]

RBPmap is currently down due to network issues, we apologize for the inconvenience

[Mandel-Gutfreund Lab @YaelmgLAB]

We're back online!

https://t.co/7VGZMZ2Vhk

[Mandel-Gutfreund Lab @YaelmgLAB]

RBPmap is back!

If you need an accurate prediction of RBP binding sites, look no further >>

https://t.co/gvm8lsWJNM

@BiologyTechnion
@TechnionLive

[Mandel-Gutfreund Lab @YaelmgLAB]

RBPmap is back!

If you need an accurate prediction of RBP binding sites, look no further >>

https://t.co/gvm8lsWJNM

@BiologyTechnion
@TechnionLive

[Mandel-Gutfreund Lab @YaelmgLAB]

Now, all that’s left are the thesis and defense… 🤓🤪

[Mandel-Gutfreund Lab @YaelmgLAB]

Amir Argoetti @AArgoetti gave a seminar on his PhD project.
Amir is the first fully-experimental doctorate student graduating from the Mandel-Gutfreund lab, so this was an emotional day.
Incredibly proud of you! We expect great things from you

[Amir Argoetti @AArgoetti]

#lncRNAfeed
Does anyone know how many base pairs around the sgRNA are closed by CRISPRi?

We are debating knockdown approaches of a nuclear lncRNA that is back to back to a protein-coding gene

@YaelmgLAB

[Mandel-Gutfreund Lab @YaelmgLAB]

@EnsenyatMiquel We are expecting RBPmap to be available again at the beginning of April.
We are sorry for the inconvenience and we will update here when it will be online again

[Amir Argoetti @AArgoetti]

I’m honored and flattered to receive The Prof. David and Harriet Gershon Excellence Fellowship.
I would like to thank the Gershon family and committee for choosing me and for appreciating my science and my social activities

[Mandel-Gutfreund Lab @YaelmgLAB]

Recipient of the Gershon award @AArgoetti gave a short presentation of his project at the Biology Faculty Retreat. Congratulations! We expect great things from you!

@BiologyTechnion
@TechnionLive

[Mandel-Gutfreund Lab @YaelmgLAB]

Great talk Galia!
We are very proud of you

[Amir Argoetti @AArgoetti]

The very talented @GaliaPolyak represents @YaelmgLAB at the faculty retreat, talking about lncRNAs-mediated regulation of human embryonic development

Great talk Galia! 🤩

@BiologyTechnion
@TechnionLive