Yingfei Wang Lab

Associate Professor at UT Southwestern
Study mitochondrial dysfunction, neurodegeneration, cell death in neurological diseases and cancers

[Yingfei Wang Lab @YingfeiWangLab]

@QingZhangLab @UTSW_Pathology @UTSWNeurosci @GDDgradprogUTSW @UTSWBrain Thanks, Qing.

[Yingfei Wang Lab @YingfeiWangLab]

Glad to share our work published today: AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis. https://t.co/Q3T1vgqj8t;
@UTSW_Pathology; @UTSWNeurosci ; @GDDgradprogUTSW
@UTSWBrain

[UTSW Department of Pathology @UTSW_Pathology]

Check out this exciting new paper by @YingfeiWangLab and colleagues on AIF-variants in mitochondrial disorders and brain development!

[Yingfei Wang Lab @YingfeiWangLab]

@Ram_Mani_PhD @UTSW_Pathology @UTSWNeurosci @GDDgradprogUTSW @UTSWBrain Thanks, Ram.

[Yingfei Wang Lab @YingfeiWangLab]

@EsraAkbay_ @UTSW_Pathology Thanks, Esra.

[Yingfei Wang Lab @YingfeiWangLab]

· AIF3 variant disrupts mitochondrial complex assembly, functions and brain development via dysregulating respiratory chain functions and glutathione-redox homeostasis
· NDI1 restores mitochondrial functions partially and protects neurons in vivo

[Yingfei Wang Lab @YingfeiWangLab]

· AIF is an underrated mammalian mitochondrial complex I alternative NAD(P)H dehydrogenase
· AIF possesses previously unrecognized glutathione reductase activity controlling GSH homeostasis

[Yingfei Wang Lab @YingfeiWangLab]

@UTSWGreenCenter @BanaszynskiLab Congratulations, Laura!

[Yingfei Wang Lab @YingfeiWangLab]

Join us for a Brain Injury & Dementia Symposium on Feb 8. 2023 at UT Southwestern Medical Center (NG3.112). @UTSW_Pathology ; @UTSWBrain ; @UTSWNeurosci ; @UTSWNeurology ;@UTSWGradSchool

[Yingfei Wang Lab @YingfeiWangLab]

@leo_jwu @Nature @jingleidi @LLizhong Congratulations, Jun and teams!!

[Yingfei Wang Lab @YingfeiWangLab]

@LilyHuangLab Congratulations Lily and team!

[Yingfei Wang Lab @YingfeiWangLab]

@JianXuLab @NatMetabolism @mckenzie__pat @CRI_UTSW @UTSWNews Congratulations Jian and team!!!

[Yingfei Wang Lab @YingfeiWangLab]

@QingZhangLab @NatureGenet @DrBrianStrahl @QinYan1 @QiZhangLab @gregwan98641292 @utswcancer @UTSW_Pathology @UNC_Lineberger @UNC_BCBP Congratulations, Qing and the team!

[Yingfei Wang Lab @YingfeiWangLab]

UT Southwestern researchers identify a regulator of breast cancer development : Newsroom - UT Southwestern, Dallas, Texas https://t.co/VGnRDWWedl

[Yingfei Wang Lab @YingfeiWangLab]

@Ram_Mani_PhD @TheBoutrosLab @UTSWNews @CPRITTexas @PCF_Science @PCFnews @UTSW_Pathology Congratulations, Ram and team!!

[Yingfei Wang Lab @YingfeiWangLab]

@MalladiLab @CD_AACR @PayalKapur5 @JBrugarolas @brekkenlab @ElizSMcKenna Congrats Srinivas and team!

[Yingfei Wang Lab @YingfeiWangLab]

Our findings on the physiological role of KDM6B in synapse plasticity and cognition may help understand the involvement of KDM6B in neurological diseases like Alzheimer’s disease and autism.

[Yingfei Wang Lab @YingfeiWangLab]

Excited to share our latest work published online in Molecular Psychiatry today: KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2 (https://t.co/LdanR3RGAG).
@UTSWBrain;
@UTSW_Pathology;
@UTSWNeurology

[Yingfei Wang Lab @YingfeiWangLab]

We revealed a fundamental mechanism underlying epigenetic regulation of synaptic vesicle numbers, synaptic activity and spine density contributing to learning and memory.