Malladi Lab - UTSW

Malladi Lab, UT Southwestern Medical Center. Studying cancer metastasis.

[Malladi Lab - UTSW @MalladiLab]

Excited to share our review on metabolic adaptations in brain metastasis in @NatureRevCancer!!
👉https://t.co/5lVVy9TfwH A pleasure to co-write with Pravat @CMTLab_IISERBPR and appreciate the support Daniela @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter

[Malladi Lab - UTSW @MalladiLab]

@KarunaMDPhD @Nature Congratulations Karuna!!

[Malladi Lab - UTSW @MalladiLab]

@ThalesPapaG @salkinstitute Congratulations!! All the best!!

[AACR @AACR]

Tumor Evolutions, Chromosomal Instability, and Metastatic Tissue Tropism: Samra Turajlic, Maxine Sun, Natalie R. Abuelsamen, Eleonora Dondossola, and Srinivas Malladi addressed this topic in a plenary session at #AACRkidney26.
@ED_PhD_ @MalladiLab @maxinesun

[Malladi Lab - UTSW @MalladiLab]

@EsraAkbay_ Congratulations Esra !!

[Malladi Lab - UTSW @MalladiLab]

@Aiims1742 @nyulangone @Perlmutter_CC @JohnPLeonardMD @nyugrossman @NYULangoneLI @NYULangoneBK @DrOscarLahoud @EmelineAvikiMD Congratulations!!!

[Malladi Lab - UTSW @MalladiLab]

Excited to host Dr. Mikala Egeblad at the next #KomenBreastCancerForum 11/19- 9am NB-5.124 @UTSWMedCenter @UTSWCancerBio @UTSWScience @UTSW_Pathology @UTSWMolBiol @utswimmuno @megeblad @JohnsHopkins @AriellaHanker @QingZhangLab #InnateImmunity #Metastasis #TMEhost See you all !!

[Malladi Lab - UTSW @MalladiLab]

@MSKCancerCenter @rosslevinemd Congratulations!!

[Dr. Deirdre Brekken @BrekkenDeirdre]

#ThankYouPostdocs #NPAW2025 https://t.co/0hMuO5uZgb

[Malladi Lab - UTSW @MalladiLab]

@yibinkang @CellCellPress @XiangZhangLab Awesome!! Congratulations!!

[Malladi Lab - UTSW @MalladiLab]

@TiansterZhang @andyzwang @utswcancer @UTSW_RadOnc @UTSWMedCenter Cheers!!

[Malladi Lab - UTSW @MalladiLab]

@Ram_Mani_PhD @jclinicalinvest @UTSWMedCenter @UTSW_Pathology @UTSWCancerBio @utswcancer Congratulations!!

[Pravat Kumar Parida @CMTLab_IISERBPR]

It was a great experience co-writing with Dr. Srinivas Malladi (@MalladiLab) on this comprehensive review on metabolic adaptations of brain metastasis published in @NatureRevCancer (https://t.co/JJqWdn66pD). Many thanks to @IISER_BERHAMPUR and @ANRFIndia for their support.

[Dr. Ariella Hanker @AriellaHanker]

Check out this review by @MalladiLab on metabolic adaptations of #brainmetastasis, with a framework for understanding/targeting metabolic vulnerabilities. It's encouraging to see the recent progress, as I lost my grandfather to a brain met, and my dad to a primary brain tumor 👇

[Malladi Lab - UTSW @MalladiLab]

@UTSW_Pathology @QingZhangLab @utswcancer @UTSWMedCenter Congratulations !!

[Malladi Lab - UTSW @MalladiLab]

@JaviGBermudez Congratulations!!

[Nature Reviews Cancer @NatureRevCancer]

#REVIEW 🚨

Parida & Malladi highlight tumour cell metabolic adaptations and crosstalk in the brain & discuss potential strategies to target these adaptations to improve outcomes for patients with brain metastasis.

📖 👇
https://t.co/IXIV9UgOAj

[Malladi Lab - UTSW @MalladiLab]

@NasserWasim @NatureRevCancer @CMTLab_IISERBPR @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter Thank you!!

[Malladi Lab - UTSW @MalladiLab]

Excited to share our review on metabolic adaptations in brain metastasis in @NatureRevCancer!!
👉https://t.co/5lVVy9TfwH A pleasure to co-write with Pravat @CMTLab_IISERBPR and appreciate the support Daniela @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter

[Malladi Lab - UTSW @MalladiLab]

@PayalKapur5 @NatureRevCancer @CMTLab_IISERBPR @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter Thank you!!

[Malladi Lab - UTSW @MalladiLab]

@BravoCorderoLab @NatureRevCancer @CMTLab_IISERBPR @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter Thank you!!

[OncoAlert @OncoAlert]

Metabolic adaptations of brain metastasis

https://t.co/hri3ouus1j

Brain🧠 metastases present a significant clinical challenge due to their high mortality and limited treatment options, driven by complex and dynamic metabolic adaptations that allow tumor cells to survive and grow within the brain’s unique microenvironment. These adaptations differ depending on the tumor's origin, genetic makeup, and ability to tolerate nutrient stress, with proliferative and dormant cells showing distinct metabolic profiles. Cancer cells rewire key metabolic pathways—such as glucose, fatty acid, and amino acid metabolism—not only for their own survival but also to manipulate brain-resident cells to support metastasis.

This metabolic heterogeneity reveals the limitations of uniform treatment strategies and highlights the need for tailored therapeutic approaches, which are the focus of emerging research in preventing and managing brain metastases.

@CMTLab_IISERBPR @MalladiLab

#OncoAlertAF
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