UTSWCancerBio

Cancer Biology

[UTSWCancerBio @UTSWCancerBio]

#WIPs highlight:Tina Andoh (Gruber Lab) presents work showing that VISTA binds highly sulfated heparan sulfate in a pH-dependent manner; a potential mechanism for VISTA-mediated immune suppression that may help guide new strategies for VISTA-targeted cancer immunotherapy. 🧬🔬

[UTSWCancerBio @UTSWCancerBio]

#WIPs highlight: Arlene Levario (Conacci-Sorrell Lab) presents work identifying ZNF692 as a novel regulator of ribosome biogenesis and nucleolar integrity. By showing that ZNF692 loss triggers nucleolar stress and may strengthen p53-mediated tumor suppression. 🧬🔬

[UTSWCancerBio @UTSWCancerBio]

#WIPs highlight: Blake Schwettmann (Maddipati & Brekken Lab) presents work identifying MIF as a driver of immune suppression in PDAC. By showing that MIF inhibition reduces tumor growth and metastasis while shifting the TME toward anti-tumor immunity. 🧬🔬

[UTSWCancerBio @UTSWCancerBio]

Standing room only for the first session of History of Molecular Biology 🧬

Packed auditorium with trainees, faculty, and UTSW leadership, an incredible start with Dr. Richard Losick. 🔬✨

[UTSWCancerBio @UTSWCancerBio]

A rare opportunity you don’t want to miss 🧬
UTSW Graduate School hosts Richard Losick (Harvard University)
for a special course on the History of Molecular Biology.
Foundational discoveries that shaped modern cancer research .
don’t miss it! 🔬

[UTSW Dermatology @UTSWDerm]

🆕JEADV: Single-cell multiomics in 22 Sézary syndrome pts defines 3 malignant T-cell subtypes and key immune-evasion programs, including KIR and JAK/STAT-linked signaling. Childs, Goff, @JosephMerolaMD , @aguilera_md , et al.

📖 https://t.co/MaoDtRbpnz

#CTCL #UTSWDerm

[UTSWCancerBio @UTSWCancerBio]

A rare opportunity you don’t want to miss 🧬
UTSW Graduate School hosts Richard Losick (Harvard University)
for a special course on the History of Molecular Biology.
Foundational discoveries that shaped modern cancer research .
don’t miss it! 🔬

[UTSWCancerBio @UTSWCancerBio]

WIPS highlight: Xiyu Liu (Zhang Lab) presents in vivo Perturb-Seq mapping genetic interaction drivers of metastasis. 🧬
PTEN-centered networks reveal how gene interactions fuel breast cancer lung metastasis and inform combinatorial therapies. 🔬

[UTSWCancerBio @UTSWCancerBio]

WIPS highlight: Emily Patterson-Rees (Strand Lab) presents a multimodal atlas of the lower urinary tract. 🧬
Single-cell and spatial profiling uncover new cell types, sex differences, and disease targets in bladder cancer, BPH, and UTIs. 🔬

[UTSWCancerBio @UTSWCancerBio]

WIPS highlight: Wei Ma (Zhang Lab)
presents an in vivo CRISPR screen identifying CHD7 as a driver of radio-resistance in brain metastasis.Loss of CHD7 increases radiosensitivity and disrupts DNA repair, highlighting it as a target to enhance radiotherapy and prevent recurrence.🔬

[UTSWCancerBio @UTSWCancerBio]

Thank you to Dr. #Leah_Banks and #Adriana_Almodova for an insightful WIPS session!

From CVs and mock interviews to negotiation strategies, international resources, and careers beyond the bench; valuable tools for our trainees. 🚀

[UTSWCancerBio @UTSWCancerBio]

Xinrui Yang (Zhang Lab| a New Cat Dad)
��💙WIPs highlight: shares how targeting Dermatopontin (DPT)—a key extracellular matrix component—may re-sensitize chemoresistant ovarian tumors and enhance chemotherapy response.
Rethinking the metastatic niche to improve patient outcomes.

[UTSWCancerBio @UTSWCancerBio]

Igor Lopes dos Santos (Conacci-Sorrell Lab)

🔬🧬WIPs highlight: Explores how the tryptophan metabolite I3P fuels hepatocellular carcinoma.
By probing its roles in AHR signaling and ferroptosis resistance, this work uncovers metabolic vulnerabilities for liver cancer therapy.

[UTSWCancerBio @UTSWCancerBio]

#WorldCancerDay ; a reminder that prevention, early detection, and equitable access to care save lives.
Support patients, back research, and push for policies that close the gap.
Together, we can reduce the burden of cancer. 💛🎗️ #CancerResearch #CancerAwareness

[UTSW Radiation Oncology @UTSW_RadOnc]

Early detection saves lives. This #WorldCancerDay, take a moment to check in with yourself and those you love. Help spread awareness and build a future where prevention and treatment are accessible to all!

[Esra Akbay @EsraAkbay_]

The day is finally here. We present a comprehensive characterization of KRAS G12C and G12D driven lung cancers. https://t.co/ITT47FRbIH

[Dr. Ariella Hanker @AriellaHanker]

🙌Hey @utswcancer @UTSWMedCenter @UTSWCancerBio @UTSWHemeOnc @UTSWScience @UTSW_Pathology @UTSWMolBiol don't miss the next #KomenBreastCancerForum feat. @CVCamachoPhD @UTSWGreenCenter 2/18 9am IN PERSON #PARP1 #FOXA1 #EstrogenReceptor #ADPRibosylation #TranscriptionalRegulation

[Prakash P. Praharaj, Ph.D. @Prakraj07]

Happy to share that I have been awarded a Postdoctoral Fellowship (2026-2029) from the American Cancer Society. Grateful to my mentor, Dr. Gerta Hoxhaj, and the Children’s Research Institute, UT Southwestern for continued support. Excited for what’s ahead!
#AmericanCancerSociety

[Todd Aguilera MD PhD @aguilera_md]

Excellent work, Peter the Cat Dad! 🐱
We started thinking about this project when he was a med student considering a PhD—when we had only ~15–20 preop SABR cases. Letting the data mature paid off. Great first correlative obs. More science to come!
10.1158/1078-0432.CCR-24-3582

[UTSW Simmons Cancer Center @utswcancer]

Published in Clinical Gastroenterology & Hepatology, #UTSW researchers found that early liver cancer detection is strongly linked to regular screening, health literacy, and clear communication with care teams, noting the need for improved trust and access. https://t.co/rYWHPJTz10

[UTSWCancerBio @UTSWCancerBio]

Peter Leung (Aguilera Lab |
Professional Cat Dad 🐈‍⬛)

🫁💥 WIPS highlight: Presurgical SAbR improves local control in pancreatic cancer; enhancing pathology and inducing immune activation (CD8⁺, NK/NKT), while maintaining overall survival despite advanced disease.