Young-Pearse Lab

The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.

[Young-Pearse Lab @YoungPearseLab]

We're lucky to have such amazing Research Technicians! Anna, Masin and Jill all presented posters today at Harvard Medical School to show off their amazing progress. We are so proud to have them as part of the team!

[Garrett Fogo @FogoGarrett]

Excited to share our new paper from the @YoungPearseLab describing interesting new connections between BAG3 and the retromer complex, as well as proteostatic machinery as it relates to Alzheimer’s disease. https://t.co/yvmO9WGobz

[Young-Pearse Lab @YoungPearseLab]

New TYP lab paper out today in @PNASNews from former PhD student Zach Augur and postdoc @FogoGarrett all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: https://t.co/BWh6nkkyc4

[Young-Pearse Lab @YoungPearseLab]

New TYP lab publication is out today! A phenomenal review by @Heuerwego, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!

[Molecular Neurodegeneration @MolNeuro]

Human cellular models of the brain to study #lipid homeostasis in #AlzheimersDisease and related dementias

Sarah E. Heuer @Heuerwego, Fasih M. Ahsan, Tracy L. Young-Pearse @YoungPearseLab @BrighamWomens #ipscs

https://t.co/a2gK03L1c7

[Young-Pearse Lab @YoungPearseLab]

Congratulations to TYP lab postdoc @Heuerwego on being awarded a F32 NRSA Postdoctoral Fellowship through the NIA, titled "Identifying the cellular consequences of ABCA7 genetic risk in Alzheimer's disease." Looking forward to more amazing findings from Dr. Heuer's work!

[Young-Pearse Lab @YoungPearseLab]

Congratulations to the Young-Pearse lab's newest doctor @GizemTerzioglu_ on her successful PhD defense!!! We are so proud of her!!

[Young-Pearse Lab @YoungPearseLab]

We are excited to welcome Nalini Oliver to the lab! We are thrilled that she chose to join our lab for her thesis through Harvard's BBS program and look forward to working with her!

[Young-Pearse Lab @YoungPearseLab]

We are happy to welcome Julia Choi to the lab as our newest undergrad! We are also excited to have Arnab Misra and Cecilia Riordan-Bourges continuing their studies in our lab this summer as well!

[Young-Pearse Lab @YoungPearseLab]

TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @FogoGarrett and PhD student Olivia Pembridge all gave great talks! @rushalzheimers #ROSMAP

[Young-Pearse Lab @YoungPearseLab]

Shoutout graduate student Olivia Pembridge who gave a fantastic talk on her work studying the role of VGF in excitatory neurons at the Annual ROSMAP conference and won the Martha Ondrey Jr. Investigator Award 🏆 @rushalzheimers #rosmap

[Young-Pearse Lab @YoungPearseLab]

We had the opportunity to present our work using iPSC models to study vascular dysfunction in AD at the Vascular Contributions to Cognitive Impairment (VCID) workshop at WashU! Great conversations and new connections. Grateful to be part of such an impactful meeting! #VCID2026

[Young-Pearse Lab @YoungPearseLab]

Shout out to our fabulous postdoc @Heuerwego who gave a great talk on her work investigating genetic risk factors influencing dysfunction in microglia in AD at the ACT Research Symposium hosted by @kpwashington ! #ACT2026

[Young-Pearse Lab @YoungPearseLab]

Exciting science from our own Dr. Benoit at the Harvard Bipolar Symposium! Her poster on a population-scale single-cell atlas of peripheral immune cells in bipolar disorder highlights the growing importance of immune mechanisms in psychiatric disease. 🔬

[Sarah Heuer, PhD @Heuerwego]

Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @YoungPearseLab that I've been working on over the past few years!
https://t.co/gQqUDvmEwG

[Young-Pearse Lab @YoungPearseLab]

We had inspiring discussions, established new collaborations, and the had the opportunity to share our work at the BD² Funded Investigators Meeting in Fort Lauderdale. We are grateful to be a part of a community working to help individuals with bipolar disorder thrive.

[Young-Pearse Lab @YoungPearseLab]

Excited to share our latest review!!🧠

“Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin”

Check it out here: https://t.co/Ws31zQsxLo

[Young-Pearse Lab @YoungPearseLab]

We are excited to share our latest publication “POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" in Brain, which we discuss in the recent Brain Podcast episode check it out here:
https://t.co/NQQN74VS5O

[Young-Pearse Lab @YoungPearseLab]

Happy Holidays from our team!✨

[Young-Pearse Lab @YoungPearseLab]

Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!

[Young-Pearse Lab @YoungPearseLab]

Thank you to Paul Tesar and Raeka Aiyar for including us in the inaugural Translational Glial Sciences Conference in the Institute for Glial Sciences at Case Western Reserve University School of Medicine. It was a great event!