Young-Pearse Lab

The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.

[Young-Pearse Lab @YoungPearseLab]

TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @FogoGarrett and PhD student Olivia Pembridge all gave great talks! @rushalzheimers #ROSMAP

[Young-Pearse Lab @YoungPearseLab]

Shoutout graduate student Olivia Pembridge who gave a fantastic talk on her work studying the role of VGF in excitatory neurons at the Annual ROSMAP conference and won the Martha Ondrey Jr. Investigator Award 🏆 @rushalzheimers #rosmap

[Young-Pearse Lab @YoungPearseLab]

We had the opportunity to present our work using iPSC models to study vascular dysfunction in AD at the Vascular Contributions to Cognitive Impairment (VCID) workshop at WashU! Great conversations and new connections. Grateful to be part of such an impactful meeting! #VCID2026

[Young-Pearse Lab @YoungPearseLab]

Shout out to our fabulous postdoc @Heuerwego who gave a great talk on her work investigating genetic risk factors influencing dysfunction in microglia in AD at the ACT Research Symposium hosted by @kpwashington ! #ACT2026

[Young-Pearse Lab @YoungPearseLab]

Exciting science from our own Dr. Benoit at the Harvard Bipolar Symposium! Her poster on a population-scale single-cell atlas of peripheral immune cells in bipolar disorder highlights the growing importance of immune mechanisms in psychiatric disease. 🔬

[Sarah Heuer, PhD @Heuerwego]

Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @YoungPearseLab that I've been working on over the past few years!
https://t.co/gQqUDvmEwG

[Young-Pearse Lab @YoungPearseLab]

We had inspiring discussions, established new collaborations, and the had the opportunity to share our work at the BD² Funded Investigators Meeting in Fort Lauderdale. We are grateful to be a part of a community working to help individuals with bipolar disorder thrive.

[Young-Pearse Lab @YoungPearseLab]

Excited to share our latest review!!🧠

“Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin”

Check it out here: https://t.co/Ws31zQsxLo

[Young-Pearse Lab @YoungPearseLab]

We are excited to share our latest publication “POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" in Brain, which we discuss in the recent Brain Podcast episode check it out here:
https://t.co/NQQN74VS5O

[Young-Pearse Lab @YoungPearseLab]

Happy Holidays from our team!✨

[Young-Pearse Lab @YoungPearseLab]

Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!

[Young-Pearse Lab @YoungPearseLab]

Thank you to Paul Tesar and Raeka Aiyar for including us in the inaugural Translational Glial Sciences Conference in the Institute for Glial Sciences at Case Western Reserve University School of Medicine. It was a great event!

[Young-Pearse Lab @YoungPearseLab]

We're excited to share our new pre-print, where @GizemTerzioglu_ et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia.

https://t.co/iS2ixs9NTA

[Young-Pearse Lab @YoungPearseLab]

Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!

[Young-Pearse Lab @YoungPearseLab]

We are excited to share our latest publication “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" in Acta Neuropathologica this week! Congratulations Zack Augur!!
https://t.co/fLoVdSxWoL

[Young-Pearse Lab @YoungPearseLab]

New TYP lab publication from co-authors Zach Augur and @FogoGarrett on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! https://t.co/VhEbwGEvRt

[Young-Pearse Lab @YoungPearseLab]

The best of luck to @alexlish47 on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

[Young-Pearse Lab @YoungPearseLab]

Huge congrats to Zack Murphy, selected as a 2025 Fujifilm Fellow at @harvardmed !! 🎉

The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences! Look out for big things ahead from Zack!

[Young-Pearse Lab @YoungPearseLab]

Huge shoutout to our brilliant graduate student @GizemTerzioglu_ for delivering a great HMS Neurobiology Pizza Talk! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

[Young-Pearse Lab @YoungPearseLab]

🧠 New study in @Brain1878, led by graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13 https://t.co/XVP2TWLw07