Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! #apoe@DrNeuroChic@MayoClinicNeuro@NeuroCellPress
Excited to share this work from our lab, out in ACS Chemical Biology! 🎉
“In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes” by previous lab member Pengju Nie and current lab members You (Emily) Wu and @ShekarMekala
https://t.co/iKgvKeIuHl
.@ZhaoNaa, Bu et al @MayoClinicNeuro@MayoClinic show that WT TREM2 reduces amyloid deposition & suppresses disease-associated #microglia only during early amyloid seeding whereas TREM2-R47H exacerbates amyloid burden during amyloid rapid growth https://t.co/13EicMZCUS
>8,300 YouTube views
>6,000 live participants
44 seminars
1 blossoming e-friendship (@rikvanderkant & @LJohnsonLab)
THANK YOU to our incredible speakers, our fantastic trainee co-hosts @brainychickJ & @dchloechung, and to all of you!
missed a seminar? https://t.co/HAbP1WTnAX
If you are a grad student/postdoc who want to share your #Alzheimer's disease research, here's a perfect chance! Showcase your work (~15min) at the new 🧠 AD Trainee Happy Hour Seminar Series 🧠 every Friday @ 3pm EST 🍸sign up under Trainee tab ⬇️https://t.co/VHEgdmmbFC
TREM2 holds off Aβ plaques, but is ineffectual once plaque growth kicks into high gear. The receptor may be most protective early in disease. https://t.co/GRVNXwbzAc
More evidences of the protective role of #TREM2 by the splendid talk of @BuGroupResearch at #AATADPD.
Importantly, the timing of the disease matters! – the earlier we enhance TREM2 function, the better? Even before amyloid plaques are formed? 🤔