Tommaso Marchetti

Research Scientist @UZH_en | @LifeScienceZH

[Waggoner Lab @LabWaggoner]

Variants in human CD48 lead to impaired T-cell immunity and increased inflammation @jclinicalinvest
https://t.co/w0PcgoHvh7 🇨🇭

[Tommaso Marchetti @_TMarchetti]

@mstockton Nope

[Michael 英泉 Eisen @mbeisen]

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!!

https://t.co/J5HekY1Pc0

[Tommaso Marchetti @_TMarchetti]

Part of my PhD work has been published!

We show that targeted IL-2 therapy, instead of worsening HLH, improves disease by inducing CD8⁺ T-cell exhaustion, an intrinsic immune brake that controls inflammation and redefines IL-2’s role in immunity.

https://t.co/euFtISFUPz

[Keystone Symposia @KeystoneSymp]

🧠 Join us for the Neural-Immune Interactions / Neurodegeneration Conference — in Whistler or online via livestream!

🔗 Register now:
https://t.co/yvauiZBUvg
https://t.co/rzfRTomij5

#KSNeuroImmune25 #KSNeuroDegen25 @rolls_asya @Michael_E_Ward_ @ErikaHolzbaur

[Neil Renic @NC_Renic]

I don’t know why people complain so much about academia. Simply finish a PhD, apply 800 times, interview 300 times, finally know someone personally on the interview panel, and move to a country you’d never previously considered. Easy as that.

[Itai Yanai @ItaiYanai]

The feedback on this new episode has been something different! Many people are saying that this might be their favorite episode so far of the Night Science Podcast!

[Brian S. Kim @itchdoctor]

Writing a new review on #neuroimmunology and re-reading this paper from @Nature by @KevinJTraceyMD and colleagues. It was published in 2000, but it literally feels like a paper submitted today. So ahead of its time!
https://t.co/LlWhxLCE84

[Kuchroo Lab @KuchrooLab]

Neuroimmune crosstalk directs T cell differentiation for optimal viral clearance. With our collaborators, we show that neuropeptide CGRP produced by neurons during infection boosts Th1 differentiation while suppressing Th2, via RAMP3 on T cells. @Nature
https://t.co/wofhTDyZcX

[Waggoner Lab @LabWaggoner]

EBV infection induces tissue-resident memory T cells in mucosal lymphoid tissues @JCI_insight
https://t.co/dnJPTzZMMH

[Tommaso Marchetti @_TMarchetti]

8) Thanks to everyone who has contributed to this project!

@supsami_14 Diana, Tiziana, Severin, Stefano, Onur and @PachlopnikL
@UZH_en @KispiZuerich @LifeScienceZH

[Tommaso Marchetti @_TMarchetti]

Could inducing cell exhaustion be the solution to stop deadly hyperinflation?

We found that directing IL-2 to overstimulated CD8 T cells triggers exhaustion and prevents lethal inflammation!

#IL2 #CD8Tcell #HLH

https://t.co/X8tlYxllAs

[Tommaso Marchetti @_TMarchetti]

7) Reversing the exhaustion caused by NARA1 proved fatal. We concluded that exhaustion, usually considered to be reverted, can be beneficial in inflammatory contexts, and IL-2, typically a T-cell stimulant, may have the opposite effect in hyper-inflammatory conditions.