Wolf Lab for Tumor Biochemistry

#MYC_Cancer #systemsbiology at @Uni_WUE with @NevenkaDudvars1 @MV4_11 @_BikashAdhikari @J_Hofstetter1 @ashwin_narain @PranjScripts @EingLorenz

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: https://t.co/zmECC5yxRS. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. https://t.co/FwBn73NmuA

[vosslab @voss_lab]

Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. https://t.co/zUiMMlYsWf

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Our new paper on TTK/Aurora PROTACs is out: https://t.co/pnhTJbw4Jf Great collaboration with the Sarli lab. Thanks to all involved!"

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Congratulations @_MarkusVogt for delivering a superb PhD defense!!!🍾🥂

[Lucas Farnung @LucasFarnung]

I have written a concise review on chromatin transcription as part of the @JMolBiol special issue on transcription elongation. Check it out!

https://t.co/3T5ESqSh0l

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We congratulate Michaela Reissland and the whole team in Markus Diefenbacher's lab on their new paper in Oncogene. In the study, they were able to demonstrate the role of USP10 in Wnt signalling in colorectal cancer models. Thank you for the opportunity to contribute.

[Oncogene Journal @oncogenejournal]

USP10 emerges as a unique therapeutic target in APC-truncated #ColorectalCancer

🔬https://t.co/0LqpFmDeuO

@DiefenbacherL
#OpenAccess

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Congratulations, Lorenz!

[Eilers Lab @MYCGyvers]

PhDone ✅
@EingLorenz finally defended his defense. After his PhD in the @_WolfLab he is now working as a Postdoc in our Lab! Fantastic defense and as always a good party afterwards!

[Gut Journal @Gut_BMJ]

#GUTAbstract by @_MarkusVogt @_WolfLab et al on

"Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2" via https://t.co/PrJkATEHoW

Paper: https://t.co/3bPBatVVZT

@DiefenbacherL @NevenkaDudvars1 #Pancreas #PancreaticCancer

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Graduate students and postdocs interested in PROTACs and Glues: Register for the AEK workshop November 4-6 in Berlin with outstanding international speakers: https://t.co/wG6QZZQWAU

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Many thanks to the press office of Kiel University for the press release about our new paper in GUT: https://t.co/WugPYLiPBJ

[Rapé Lab @RapeLab]

Congratulations to the amazing team at @Nurix_Tx for the continued success of their brain-penetrant BTK degrader in the clinic!
https://t.co/LQD04r9mvm

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany).
We look forward to your application!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Congratulations to all the authors on their great work!

[Markus Damme @DammeMarkus]

More than happy to finally see our paper out in @NatureCellBio! We de-orphanized MFSD1 as a lysosomal dipeptide uniporter. Fantastic work of @Kathaschnatta, @OceaneGuelle,
@AllUNeedIsLoew and Bruno Gasnier: https://t.co/wbWgHGoAFP so nice to see the structure of MFSD1&GLMP!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Thank you!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Congratulations to @MV4_11, @NevenkaDudvars1 and the other contributing members of @_WolfLab and many thanks to our collaborators @MYCGyvers, @seyvos, @WiegeringLab, @DiefenbacherL, @GeorgGasteiger, Florian Erhard, Stefan Knapp and Dieter Saur.

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Acute degradation of RUVBL1 in transplanted PDAC tumors via the auxin-inducible degron (AID) system resulted in complete tumor regression in immunocompetent mice which was preceded by infiltration with CD3-positive immune cells.

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Thereby, targeting of RUVBL1/2 transforms PDAC into an immunologically “hot” tumor, responsive to immunotherapy. In summary, our work identified the MYC-RUVBL1/2 axis as a druggable vulnerability of MYC-driven cancer.

[Wolf Lab for Tumor Biochemistry @_WolfLab]

RUVBL1/2 interacts directly with MYC and gets recruited to chromatin by MYC, where it is required to establish oncogenic and immune-evasive gene expression.

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We investigated the possibility of targeting the prominent oncogene MYC via its binding partners. We prioritized MYC binding partners by genetic screens in PDAC cells in culture and in immunocompetent mice.

[Wolf Lab for Tumor Biochemistry @_WolfLab]

While PDAC dependencies in cell culture followed public essentiality data of the @CancerDepMap portal, dependencies on MYC binding partners were reduced in vivo. Among the most essential MYC binding partners in vivo were RUVBL1 and RUVBL2 which form a AAA ATPase complex.