vosslab

Biochemistry/cell biology research group @kieluni | proteolytic processing of Golgi enzymes and Golgi organisation | PI tweeting | now mainly at bsky

[vosslab @voss_lab]

My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! Deadline: May 1st. #glycotime #SPPL3

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: https://t.co/zmECC5yxRS. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

[Markus Damme @DammeMarkus]

Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! https://t.co/vwcNoDwvHg

[J Cell Science @J_Cell_Sci]

Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules.
Highlight: https://t.co/7LFkZFwrNu
Article: https://t.co/ir3mgUOObU

[The EMBO Journal @embojournal]

Our final 2024 issue!
Highlight: New players in lysosomal sorting via mannose-6-phosphate
mRNA deadenylation & decay relations
Plant ALBA proteins facilitate m6A reading
and lots more!
Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al
https://t.co/DKsxYZQ852

[vosslab @voss_lab]

Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion.
https://t.co/WfIlNm50FZ

[WinterLab @LysoProteomics]

Great collaboration with the @voss_lab out now in EMBO Journal! Congratulations Matthias for this nice work!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. https://t.co/FwBn73NmuA

[The EMBO Journal @embojournal]

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Sabrina Jabs, Matthias Voss et al
https://t.co/pphxikC470

[Cell Biology J-Club @cell_club]

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Journal https://t.co/kmxAl3slAu

[vosslab @voss_lab]

Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. https://t.co/zUiMMlYsWf

[vosslab @voss_lab]

New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 https://t.co/8TFlUKbCrT

[Markus Damme @DammeMarkus]

I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or https://t.co/FvRjn4vPSU Get in touch with me! Repost & spread the word!

[Wolf Lab for Tumor Biochemistry @_WolfLab]

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany).
We look forward to your application!

[Cell Biology J-Club @cell_club]

Happy Golgi Day

[Tak Sekine @SekineTak]

Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣���
https://t.co/D3KVjjDpxv

[vosslab @voss_lab]

Exciting and comprehensive paper - and notably another study that underscores the physiological relevance of SPPL3

[Olli Dufva @ollidufva]

Our resource on NK cell - cancer interactions is now out in @ImmunityCP

https://t.co/UIT3RwoKGq

We identify tumor-induced NK cell states at single-cell resolution and tumor-intrinsic resistance mechanisms using CRISPR functional genomics

Explore: https://t.co/AzR7A6h6QI

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[vosslab @voss_lab]

Finally managed to find time for another round of #cytosis with the lab.

[vosslab @voss_lab]

@hirenj ... or a protease-independent process. Curious also from which tissue(s)/cells NDST1 here is coming.

[vosslab @voss_lab]

@hirenj Interesting - and we really don't have much of an idea of SPPL3 regulation. With the many substrates known, not sure it could actually catalyse a somewhat selective release of only one Golgi protein. Could also be another protease at play here...