My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! Deadline: May 1st. #glycotime#SPPL3
Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: https://t.co/zmECC5yxRS. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!
Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules.
Highlight: https://t.co/7LFkZFwrNu
Article: https://t.co/ir3mgUOObU
Our final 2024 issue!
Highlight: New players in lysosomal sorting via mannose-6-phosphate
mRNA deadenylation & decay relations
Plant ALBA proteins facilitate m6A reading
and lots more!
Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al
https://t.co/DKsxYZQ852
Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. https://t.co/FwBn73NmuA
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Sabrina Jabs, Matthias Voss et al
https://t.co/pphxikC470
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Journal https://t.co/kmxAl3slAu
Out now: Our collaborative #Golgi#glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. https://t.co/zUiMMlYsWf
I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or https://t.co/FvRjn4vPSU Get in touch with me! Repost & spread the word!
Our resource on NK cell - cancer interactions is now out in @ImmunityCP
https://t.co/UIT3RwoKGq
We identify tumor-induced NK cell states at single-cell resolution and tumor-intrinsic resistance mechanisms using CRISPR functional genomics
Explore: https://t.co/AzR7A6h6QI
1/
@hirenj Interesting - and we really don't have much of an idea of SPPL3 regulation. With the many substrates known, not sure it could actually catalyse a somewhat selective release of only one Golgi protein. Could also be another protease at play here...