Dimitrije Ivančić

I read, write and edit DNA at @geochurch lab @harvardmed, @Integra_Tx and Thesian Bio

[Dimitrije Ivančić @_dimiid]

Check out our latest work about discovery and engineering of PiggyBac transposases! 🧵

[Nature Biotechnology @NatureBiotech]

Discovery and protein language model-guided design of hyperactive transposases https://t.co/hKqggIAjuG

[Jake Wintermute 🧬/acc @SynBio1]

Dank memes for biosecurity red teams

[Dimitrije Ivančić @_dimiid]

@jrkelly @Ginkgo Looking forward to see cell line DNA transfection + luciferase/fluorescence readout. Many therapeutic protein approaches could be enabled!

[Dimitrije Ivančić @_dimiid]

@fabriciocarraro @ferruz_noelia 100%

[Roger Castells @rcastellsg]

We’re looking for an enthusiastic postdoc to join our team. 😊

The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪

Position funded for 3 years.

Please share 🙏

Job description and details (deadline: October 11th): https://t.co/GIvf8LmbpU

[Marc Güell @marcguellc]

Very happy to report today bioprospecting and AI-generation of high performance gene writers @NatureBiotech @Synbio_Lab_UPF @Integra_Tx @UPFBarcelona

https://t.co/AwfMVdR7qy

READ/WRITE tech fueled DNA molecular technologies development. Extremely exciting to see how AI starts to enable to 'SPEAK' the language of life. Enabling the generation of synthetic diversity is a fundamental step for future synthetic evolution which opens new horizons in engineering biology.

[Dimitrije Ivančić @_dimiid]

This work has been possible thanks to an incredible team effort w/ Alejandro, @marcguellc @avenciasm @ferruz_noelia and @Integra_Tx

@UPFbiomed @UPFBarcelona @CRGenomica @the_prbb

[Dimitrije Ivančić @_dimiid]

Check out our latest work about discovery and engineering of PiggyBac transposases! 🧵

[Nature Biotechnology @NatureBiotech]

Discovery and protein language model-guided design of hyperactive transposases https://t.co/hKqggIAjuG

[Dimitrije Ivančić @_dimiid]

We explored and experimentally tested the natural diversity of PiggyBac transposases. We then used this natural data to train protein language models. This generated protein variants with increased efficiency compared to the the current best PiggyBac transposase, HyPB.

[Dimitrije Ivančić @_dimiid]

The improved variants are compatible with therapeutic T cell editing and Cas9-guided programmable integration. We also observed domain acquisitions in parts of the HyPB phylogeny. Stay tuned for future work on improving gene writing systems.🧬❇️

[Tae Seok Moon @Moon_Synth_Bio]

#SynBYSS Thur 10am USA CT
174th, Sep 18: Dr Vivek Mutalik @vivek_mutalik @BerkeleyLab & Dr Dimitrije Ivančić @_dimiid @harvardmed

175th, Oct 2: Prof Jose Avalos @javalosLAB @Princeton & Prof Hannes Beyer @HHU_de, Germany

Zoom link for audience:
https://t.co/Y2PGIBUC44

[Ahmed mahas @AIMahas]

1. Happy to share our latest work @biorxivpreprint on developing SONAR (Sensing Of Nucleic acids using ASOs and Reverse-transcriptases) for sensing and responding to nucleic acids in living cells.
https://t.co/2k74P3RvOk
👇🧵

[Ivan Milenkovic @IvanBeki]

I am very proud to share that our ‘epitranscriptomic fingerprinting’ manuscript is now published in @MolecularCell ! You can access the article here: https://t.co/40fB4MJF1T; for highlights see the thread below. (1/11)

[Roger Castells @rcastellsg]

We're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out!

We already have two open, fully funded positions:
🔬- Postdoc: https://t.co/cKH9W9uNOG
🧪- Senior Scientist: https://t.co/ZsnAaGMrZ8

[Ivan Milenkovic @IvanBeki]

Into (r)RNA modifications? Check out the new review article by @EvaMariaNovoa and me, out today in @TrendsCellBio!

[Dimitrije Ivančić @_dimiid]

When you try to understand the results of your screen but the top hit is the X protein ...🤔

[Integra Therapeutics @Integra_Tx]

Join us at 11th Mammalian Synthetic Biology Workshop in Boston! https://t.co/zeC1DY2Pxh

Our Innovation Scientist Dimitrije Ivančić (@_dimiid) will present new PiggyBac transposases to increase the performance of #FiCAT

Chairs: @GallowayLabMIT & @johntngo @BostonU_BME

#mSBW2024

[UPF Medicine and Life Sciences @UPFbiomed]

#JobOffer #JobPosition
The @Synbio_Lab_UPF, located at @the_prbb, is recruiting an Immune Cell Engineering Scientist to join our team.
The project involves developing technologies for in-vivo immune cell modification for #CART therapies.

Apply now 👇🏽
https://t.co/WxvSCyev3n

[Dimitrije Ivančić @_dimiid]

@grdmng Thanks Gerard! The pleasure is mine. Looking forward to exciting times ✨🤗

[Dimitrije Ivančić @_dimiid]

@GaelleTales congratulations Gaëlle!