Michelle Yu

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT In this phase 3 RCT, patients with invasive aspergillosis were given either posaconazole or voriconazole. For all-cause mortality, posaconazole was found to be non-inferior to voriconazole up until day 42.

https://t.co/aKDPJbop0L

[Michelle Yu @_michelleyu]

https://t.co/WDu10YhsjJ
@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT A combination of ceftazidime-avibactam and aztreonam may be useful in patients with S. maltophilia infections who are unable to tolerate other available agents. This combination works against L1 and L2 β-lactamases to allow aztreonam to escape inactivation.

[Michelle Yu @_michelleyu]

https://t.co/31MV0bxRH3
@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT A retrospective study across VA medical centers found that the negative predictive value (NPV) of MRSA nares screening for ruling out a MRSA infection was 96.5%. The lowest NPVs were in wound cultures (93.1%), device cultures (91.6%), and graft cultures ( 91.9%).

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT When a patient is on ECMO, there are a few variables that may warrant an increased antibiotic dose. These variables include the drug's volume of distribution, octanol‐water partition coefficient (log P), and adhesion to the circuit components.

https://t.co/iOTWM4GdVU

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT CLSI reports a susceptible dose-dependent (SDD) breakpoint of ≤4 μg/mL for daptomycin and E. faecium based on a dose of 8–12 mg/kg/day. Daptomycin does not have SDD breakpoints for other Enterococcus spp. such as E. faecalis.
https://t.co/hPMI4r2Pwa

[Michelle Yu @_michelleyu]

START: https://t.co/EuAMluK6ey
TEMPRANO:
https://t.co/Tuk54xIkBz

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT The START and TEMPRANO trials found that immediate ART when CD4>500 cells/mm3 results in greater clinical benefit compared to waiting for CD4 counts to decline. Studied outcomes included both AIDs and non-AIDs events.

[Michelle Yu @_michelleyu]

https://t.co/laCgtgjFCY
@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT CREDIBLE-CR is a trial that studied patients with a carbapenem-resistant Gram-negative pathogen who were randomly assigned cefiderocol or best available therapy (BAT). Cefidericol was found to have similar clinical efficacy to BAT but higher rates of all-cause mortality.

[Michelle Yu @_michelleyu]

#OTILT It is recommended that patients with Streptococcus bovis bacteremia or endocarditis undergo GI evaluation, as this bacterium has been linked to colorectal cancer.

https://t.co/LBJFwTP17v
@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT Studies demonstrate that the use of albumin (in addition to antibiotics) to treat SBP can reduce in-hospital mortality and renal impairment. This may be due to albumin's anti-inflammatory properties and ability to decrease intravascular volume.
https://t.co/2Qdf6zkrgp

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT The SOLUBIC study examined the bioavailability of BIC/TAF/FTC tablets in healthy adults when crushed in food or dissolved in water. Only the dissolved tablet was found to be bioequivalent to a solid tablet.

https://t.co/umhoagZBjL

[Michelle Yu @_michelleyu]

@BWDionne @davidwkubiak @jeffpears0n @ShelleyJeon @SikandarIDAPPE

[Michelle Yu @_michelleyu]

#OTILT Ceftriaxone may lead to kernicterus in neonates via the displacement of bilirubin from albumin binding sites. This leads to increased serum concentrations of bilirubin and accumulation in brain tissue.
https://t.co/Tk4P1OPWSa